A randomized phase II trial of interleukin-2/interferon-α plus bevacizumab versus interleukin-2/interferon-α in metastatic renal cell carcinoma (mRCC): Results from the Danish Renal Cancer Group (DARENCA) study 1.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 4563-4563 ◽  
Author(s):  
Frede Donskov ◽  
Niels Viggo Jensen ◽  
Torben Smidt-Hansen ◽  
Line Brondum ◽  
Poul F. Geertsen
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Phase Ii ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Phase Ii Trial ◽  
Interleukin 2 ◽  
Interferon Α ◽  
Cancer Group ◽  
Randomized Phase Ii

A randomized phase II trial of Interleukin-2 in combination with four different doses of bryostatin in patients with renal cell carcinoma

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 4608-4608
Author(s):  
A. C. Peterson ◽  
H. Harlin ◽  
T. Karrison ◽  
J. A. Knost ◽  
J. W. Kugler ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Phase Ii ◽  
Renal Cell ◽  
Phase Ii Trial ◽  
Interleukin 2 ◽  
Randomized Phase Ii ◽  
Different Doses

Subcutaneous interleukin-2, interferon alfa-2a, and continuous infusion of fluorouracil in metastatic renal cell carcinoma: a multicenter phase II trial. Groupe Français d'Immunothérapie.

1998 ◽  
Vol 16 (8) ◽  
pp. 2728-2732 ◽  
Author(s):  
A Ravaud ◽  
B Audhuy ◽  
F Gomez ◽  
B Escudier ◽  
T Lesimple ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Continuous Infusion ◽  
Phase Ii ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Renal Carcinoma ◽  
Phase Ii Trial ◽  
Interleukin 2 ◽  
Interferon Alfa

PURPOSE A phase II trial was designed to determine the efficacy and the tolerance of interleukin-2 (IL-2), interferon alfa-2a (IFNalpha), and fluorouracil (5-FU) in patients with metastatic renal cell carcinoma. PATIENTS AND METHODS One hundred eleven patients were included. Patients received subcutaneous IL-2 9 x 10(6) IU daily for 6 days and IFNalpha 6 x 10(6) IU on days 1, 3, and 5 every other week for 8 weeks. 5-FU was administered through a continuous infusion at 600 mg/m2 for 5 consecutive days for 1 week every 4 weeks. RESULTS The response rate was 1.8% (95% confidence interval [CI], 0% to 4.3%) with only two partial responses (PRs). Toxicity was moderate with 3.6% grade 4 events and two deaths related to treatment. CONCLUSION This regimen of IL-2, IFNalpha, and 5-FU in patients with metastatic renal cell carcinoma was ineffective. The results raise the question of the dose and schedule of subcutaneous cytokines that must be used in metastatic renal carcinoma.

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