Acute toxicity data from POUT: A phase III randomized trial of peri-operative chemotherapy versus surveillance in upper tract urothelial cancer.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e16138-e16138
Author(s):  
Alison J. Birtle ◽  
Lauren Maynard ◽  
Mark Johnson ◽  
Roger Kockelbergh ◽  
Rebecca Lewis ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Randomized Trial ◽  
Urothelial Cancer ◽  
Phase Iii ◽  
Toxicity Data ◽  
Upper Tract ◽  
Upper Tract Urothelial Cancer

scholarly journals The Role of Chemotherapy in Upper Tract Urothelial Carcinoma

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Peter H. O'Donnell ◽  
Walter M. Stadler
Keyword(s):  
Urothelial Carcinoma ◽  
Urothelial Cancer ◽  
Locally Advanced ◽  
Standard Of Care ◽  
Upper Tract Urothelial Carcinoma ◽  
Phase Iii ◽  
Upper Tract ◽  
Cancer Of The Bladder ◽  
Upper Tract Urothelial Cancer ◽  
Direct Data

Locally advanced upper tract urothelial carcinoma has a poor prognosis. While surgery represents the only potentially curable therapeutic intervention, recurrences are common and typically systemic in nature. It is thus reasonable to consider perioperative chemotherapy in an effort to decrease the risk of recurrence. There are very little direct data providing clinical guidance in this scenario. For urothelial cancer of the bladder, there are randomized phase III data demonstrating a survival advantage with neoadjuvant cisplatin-based combination chemotherapy. Although arguments favoring adjuvant chemotherapy could be made for upper tract urothelial cancer, the loss of renal function that occurs with nephrectomy can complicate administration of appropriate perioperative treatment. Therefore, by analogy to urothelial carcinoma of the lower tract, it is argued that cisplatin-based neoadjuvant chemotherapy should be the standard of care for patients with locally advanced upper tract urothelial cancer.

Results of POUT - a phase III randomised trial of peri-operative chemotherapy versus surveillance in upper tract urothelial cancer (UTUC)

2018 ◽  
Vol 17 (2) ◽  
pp. e1431-e1432 ◽  
Author(s):  
A. Birtle ◽  
M. Johnson ◽  
R. Kockelbergh ◽  
F. Keeley ◽  
J. Catto ◽  
...  
Keyword(s):  
Urothelial Cancer ◽  
Randomised Trial ◽  
Phase Iii ◽  
Upper Tract ◽  
Upper Tract Urothelial Cancer

Molecular subtypes of upper tract urothelial cancer: Setting the stage for precision therapy

Cancer Cell ◽  
2021 ◽  
Vol 39 (6) ◽  
pp. 745-747
Author(s):  
David J. McConkey ◽  
Nirmish Singla ◽  
Phillip Pierorazio ◽  
Kara Lombardo ◽  
Andres Matoso ◽  
...  
Keyword(s):  
Urothelial Cancer ◽  
Molecular Subtypes ◽  
Upper Tract ◽  
Precision Therapy ◽  
Upper Tract Urothelial Cancer ◽  
Cancer Setting
Sign in / Sign up

Export Citation Format

Share Document