Compensation Following Cerebellar Damage in Man

2021 ◽  
pp. 125-130
Author(s):  
Robert S. Dow
Keyword(s):  
Cerebellar Damage

Ultrastorcture of Cerebellar Purkinje Cells in Rats Subjected To Partial Global Cerebral Ischemia

1985 ◽  
Vol 43 ◽  
pp. 674-675
Author(s):  
R.V.W. Dimlich ◽  
M.H. Biros
Keyword(s):  
Cerebral Ischemia ◽  
Purkinje Cells ◽  
Cell Types ◽  
Microscopic Level ◽  
Global Cerebral Ischemia ◽  
Light Microscopic Level ◽  
Cerebellar Damage ◽  
Cerebellar Injury ◽  
Cerebellar Purkinje Cells ◽  
Cell Changes

In severe cerebral ischemia, Purkinje cells of the cerebellum are one of the cell types most vulnerable to anoxic damage. In the partial (forebrain) global ischemic (PGI) model of the rat, Paljärvi noted at the light microscopic level that cerebellar damage is inconsistant and when present, milder than in the telencephalon, diencephalon and rostral brain stem. Cerebellar injury was observed in 3 of 4 PGI rats following 5 minutes of reperfusion but in none of the rats after 90 min of reperfusion. To evaluate a time between these two extremes (5 and 90 min), the present investigation used the PGI model to study the effects of ischemia on the ultrastructure of cerebellar Purkinje cells in rats that were sacrificed after 30 min of reperfusion. This time also was chosen because lactic acid that is thought to contribute to ischemic cell changes in PGI is at a maximum after 30 min of reperfusion.

Analysis of silymarin-modulating effects against acrylamide-induced cerebellar damage in male rats: Biochemical and pathological markers

2021 ◽  
Vol 115 ◽  
pp. 101964
Author(s):  
Hany Elsawy ◽  
Abdullah M. Alzahrani ◽  
Manal Alfwuaires ◽  
Azza Sedky ◽  
Eman E. El- Trass ◽  
...  
Keyword(s):  
Male Rats ◽  
Cerebellar Damage

Coordination of aimed movements in a case of unilateral cerebellar damage

1994 ◽  
Vol 32 (7) ◽  
pp. 827-846 ◽  
Author(s):  
Patrick Haggard ◽  
John Jenner ◽  
Alan Wing
Keyword(s):  
Cerebellar Damage

scholarly journals Proprioceptive Localization Deficits in People With Cerebellar Damage

2016 ◽  
Vol 16 (2) ◽  
pp. 427-437 ◽  
Author(s):  
Heidi M. Weeks ◽  
Amanda S. Therrien ◽  
Amy J. Bastian
Keyword(s):  
Cerebellar Damage

scholarly journals Normal-Appearing Cerebellar Damage in Neuromyelitis Optica Spectrum Disorder

2019 ◽  
Vol 40 (7) ◽  
pp. 1156-1161
Author(s):  
J. Sun ◽  
N. Zhang ◽  
Q. Wang ◽  
X. Zhang ◽  
W. Qin ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Cerebellar Damage

The cooking therapy for cognitive rehabilitation of cerebellar damage: A case report and a review of the literature

2019 ◽  
Vol 59 ◽  
pp. 357-361 ◽  
Author(s):  
Antonio Cerasa ◽  
Francesco Arcuri ◽  
Luigina Maria Pignataro ◽  
Sebastiano Serra ◽  
Demetrio Messina ◽  
...  
Keyword(s):  
Case Report ◽  
Cognitive Rehabilitation ◽  
Review Of The Literature ◽  
Cerebellar Damage

Do Children With Focal Cerebellar Lesions Show Deficits in Shifting Attention?

2004 ◽  
Vol 92 (3) ◽  
pp. 1856-1866 ◽  
Author(s):  
B. Schoch ◽  
B. Gorissen ◽  
S. Richter ◽  
A. Ozimek ◽  
O. Kaiser ◽  
...  
Keyword(s):  
Reaction Times ◽  
Motor Deficits ◽  
Attention Task ◽  
Original Proposal ◽  
Cerebellar Damage ◽  
Mri Scans ◽  
Significant Impairment ◽  
Cerebellar Lesions ◽  
Degenerative Disorder ◽  
Shifting Attention

More recent findings suggest a possible role of the cerebellum in nonmotor functions. Disability of individuals with cerebellar damage in rapidly shifting attention is one frequently used example to support cerebellar involvement in mental skills. The original proposal was based on findings in five children with chronic surgical lesions of the cerebellum and a young adult with a degenerative disorder. The aim of the present study was to repeat Akshoomoff and Courchesne's initial findings in a larger group of children with focal cerebellar lesions. Ten children with cerebellar lesions and 10 age- and sex-matched controls were tested. Neocerebellar areas were affected in all children with cerebellar damage except one based on detailed analysis of MRI scans. Subjects had to perform a focus and a shift attention task. Two visual and two auditory stimuli were presented in a pseudorandom order. An ellipse and a high-pitched tone were presented less frequently than a circle and a low-pitched tone. Rare stimuli were presented at five different time intervals. In the focus tasks, subjects had to react to the same rare stimulus of one of the two modalities. In the shift task, subjects had to switch between the two rare stimuli. Motor deficits based on reaction times were small in cerebellar children compared with controls. The ability of target detection did not significantly differ in the children with cerebellar lesions compared with the control children in both the focus and the shift attention task. In particular, children with cerebellar damage showed no significant impairment in rapid (<2 s) shifts of attention. The present findings indicate that the cerebellum may be less critical in attention related processes than suggested previously.

scholarly journals Evaluation of cerebellar function scores in relation to cerebellar axonal loss in multiple sclerosis

2020 ◽  
Author(s):  
F. Boonstra ◽  
S. Gajamange ◽  
G. Noffs ◽  
T. Perera ◽  
M. Strik ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Diffusion Mri ◽  
Lesion Volume ◽  
Axonal Loss ◽  
Cerebellar Dysfunction ◽  
Clinical Assessments ◽  
Cerebellar Function ◽  
Cerebellar Damage ◽  
Primary Driver ◽  
And Diffusion

AbstractBackgroundCerebellar damage is common in people with multiple sclerosis (pwMS) and is associated with worse progression and relapse recovery. Studies into the importance of the cerebellum in pwMS are hampered by limited understanding of cerebellar damage and its relation to cerebellar function in pwMS.ObjectiveExamine axonal loss, as a primary driver of progressive neurological decline, in the cerebellum using advanced diffusion MRI and compare axonal loss with cerebellar dysfunction in pwMSMethodsWe recruited 55 pwMS and 14 healthy controls. Clinical assessments included scale for the assessment and rating of ataxia (SARA), and Bain tremor ratings. Subjects underwent FLAIR, T1-weighted and diffusion MRI. Cerebellar grey and white matter and lesion volume were calculated. Cerebellar axonal loss was examined with fibre-specific markers. Fibre density and cross-section (FDC) accounts for microscopic and macroscopic changes in a fibre bundle.ResultsLoss of cerebellar FDC was associated with increased SARA (r=-0.42, p<0.01) and tremor severity (rho=-0.35, p=0.01). Cerebellar lesion volume correlated with SARA (r=0.49, p<0.01) and tremor severity (rho=0.41, p=0.01).ConclusionFibre-specific measures of cerebellar pathology could provide a functionally relevant marker of cerebellar damage in MS. Future trials using fibre-specific markers are needed to further characterize cerebellar pathology in pwMS and understand its significance in disease progression.

scholarly journals A comparison of the role of the motor cortex in recovery from cerebellar damage in young and adult rats

1974 ◽  
Vol 12 (2) ◽  
pp. 177-198 ◽  
Author(s):  
Rebekah L. Smith ◽  
Thomas Parks ◽  
Gary Lynch
Keyword(s):  
Motor Cortex ◽  
Adult Rats ◽  
Cerebellar Damage

scholarly journals Effective reinforcement learning following cerebellar damage requires a balance between exploration and motor noise

Brain ◽  
2015 ◽  
Vol 139 (1) ◽  
pp. 101-114 ◽  
Author(s):  
Amanda S. Therrien ◽  
Daniel M. Wolpert ◽  
Amy J. Bastian
Keyword(s):  
Reinforcement Learning ◽  
Motor Noise ◽  
Cerebellar Damage ◽  
Effective Reinforcement
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