Ballota pseudodictamnus (L.) Benth. (Lamiaceae), Salvia fruticosa Mill.
(Lamiaceae) and Thapsia garganica L. (Apiaceae) are three well-known
medicinal plants from the Libyan flora, which have long been used for the
treatment of inflammations. The aim of the present study was to investigate,
for the first time, the anti-inflammatory property of the methanol (MeOH)
extracts of the aerial parts of these plants. Shade-dried and ground aerial
parts of B. pseudodictamnus, S. fruticosa) and T. garganica were
Soxhlet-extracted with MeOH. The extracts were concentrated by evaporation
under reduced pressure at 40?C. The anti-inflammatory activity of the
extracts was evaluated using the carrageenan-induced mice paw edema model.
The administration of the extracts at a dose of 500 mg/kg body weight
produced statistically significant inhibition (p < 0.05) of edema within 3 h
of carrageenan administration. The results demonstrated significant
anti-inflammatory properties of the test extracts. Among the extracts, the S.
fruticosa extract exhibited the most significant inhibition of inflammation
after 3 h (62.1%). Thus, S. fruticosa could be a potential source for the
discovery and development of newer anti-inflammatory ?leads? for drug
development. The anti-inflammatory activity of B. pseudodictamnus and S.
fruticosa could be assumed to be related to high levels of phenolic
compounds, e.g., flavonoids, present in these plants.
In-vivo and in-vitro screening of medicinal plants for their anti-inflammatory activity: an overview
