Background/Aim. The symptoms of gastroesophageal reflux desease (GERD) are
among the most common complaints for which patients are indicated for
visiting gastroenterologist. It occurs as a result of the effect made by
gastric reflux contents that moves into the esophagus. The prevalence of all
forms of GERD is 40%. The aim of this study was to analyze the grade of
esophagitis, chromendoscopical and histological findings of esophagus in
patients with GERD before and after the therapy. Methods. A prospective study
included 90 patients with symptoms of GERD, divided into 2 groups depending
on whether they had endoscopic signs of gastroezophageal reflux (group ERD),
or not (group NERD). All the patients had esophagogastroduodenoscopy,
chromoendoscopy staining, test for Helicobacter pylori and histological
findings of the esophagus. In the patients with Helicobacter pylori infection
eradication therapy was done. Results. Esophagitis-B level was present in
most of the patients. Among the groups, roughly the same number responded to
positive findings on chromoendoscopy. After the therapy, chromoendoscopy was
significantly negative in both groups of the patients comparing to
chromoendoscopy before the therapy (p = 0.00001). Multiplication and
elongation of papilla, basal cell hyperplasia, vascular dilatation,
increasing of mitotic activity and the presence of polymorphonuclear
leukocyte cells were statistically more frequent histological findings in the
group ERB compared to the group NERB. After the therapy, the patients in both
groups had statistically less histological findings of appropriate esophageal
parameters. Conclusion. Chromoendoscopy combined with the standard endoscopy
increases the sensitivity and specificity for reflux disease. Histology in
the reflux disease is associated with endoscopic and clinical findings so
that the localization of taking biopsies and histological criteria of
pathohistological changes must be clearly defined. Multiplication and
elongation of papilla, basal cell hyperplasia and the presence of
polymorphonuclear leukocytes are the most relevant criteria in the diagnosis
NERD.
MYB-NFIB gene fusion in prostatic basal cell carcinoma: clinicopathologic correlates and comparison with basal cell adenoma and florid basal cell hyperplasia
