Comparative Study of Five Weighted Parametric Multiple Testing Methods for Correlated Multiple Endpoints in Clinical Trials

2021 ◽  
pp. 096228022110130
Author(s):  
Wei Wei ◽  
Denise Esserman ◽  
Michael Kane ◽  
Daniel Zelterman

Adaptive designs are gaining popularity in early phase clinical trials because they enable investigators to change the course of a study in response to accumulating data. We propose a novel design to simultaneously monitor several endpoints. These include efficacy, futility, toxicity and other outcomes in early phase, single-arm studies. We construct a recursive relationship to compute the exact probabilities of stopping for any combination of endpoints without the need for simulation, given pre-specified decision rules. The proposed design is flexible in the number and timing of interim analyses. A R Shiny app with user-friendly web interface has been created to facilitate the implementation of the proposed design.


1982 ◽  
Vol 3 (2) ◽  
pp. 136
Author(s):  
Daniel G. Seigel ◽  
Roy C. Milton

2019 ◽  
pp. 216847901985599
Author(s):  
Kentaro Sakamaki ◽  
Seitaro Yoshida ◽  
Yusuke Morita ◽  
Toshifumi Kamiura ◽  
Katsuhiro Iba ◽  
...  

2020 ◽  
Vol 10 (2) ◽  
pp. 199-248 ◽  
Author(s):  
Campbell R Harvey ◽  
Yan Liu ◽  
Alessio Saretto

Abstract In almost every area of empirical finance, researchers confront multiple tests. One high-profile example is the identification of outperforming investment managers, many of whom beat their benchmarks purely by luck. Multiple testing methods are designed to control for luck. Factor selection is another glaring case in which multiple tests are performed, but numerous other applications do not receive as much attention. One important example is a simple regression model testing five variables. In this case, because five variables are tried, a t-statistic of 2.0 is not enough to establish significance. Our paper provides a guide to various multiple testing methods and details a number of applications. We provide simulation evidence on the relative performance of different methods across a variety of testing environments. The goal of our paper is to provide a menu that researchers can choose from to improve inference in financial economics. (JEL G0, G1, G3, G5, M4, C1)


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