PULMONARY FUNCTION TESTS IN VERY LOW BIRTH INFANTS RANDOMIZED TO A DOUBLE-BLIND PLACEBO-CONTROLLED DEXAMETHASONE TRIAL. † 1158

To determine whether thyrotoxicosis has an effect on the asthmatic state in subjects with mild asthma, airway responsiveness, lung function, and exercise capacity were measured in a randomized double-blind placebo-controlled trial before and after liothyronine (triiodothyronine, T3)-induced thyrotoxicosis. Baseline evaluation of 15 subjects with mild asthma included clinical evaluation, thyroid and routine pulmonary function tests, airway responsiveness assessment by methacholine inhalation challenge, and a symptom-limited maximal exercise test. For all subjects, the initial testing revealed that the dose of methacholine which provoked a 20% fall in forced expiratory volume in 1s (PD20) was in a range consistent with symptomatic asthma. There was no significant change in pulmonary function tests, airway reactivity (PD20), or exercise capacity in either the placebo or the T3-treated groups. Thyroid function tests confirmed mild sustained thyrotoxicosis in the T3-treated groups. We conclude that mild T3-induced thyrotoxicosis of 4-wk duration had no effect on lung function, airway responsiveness, or exercise capacity in subjects with mild asthma.

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Effect of Zataria multiflora on serum cytokine levels and pulmonary function tests in sulfur mustard-induced lung disorders: A randomized double-blind clinical trial

Journal of Ethnopharmacology ◽

10.1016/j.jep.2019.112325 ◽

2020 ◽

Vol 248 ◽

pp. 112325 ◽

Cited By ~ 4

Author(s):

Mohammad Reza Khazdair ◽

Vahideh Ghorani ◽

Azam Alavinezhad ◽

Mohammad Hossein Boskabady

Keyword(s):

Clinical Trial ◽

Pulmonary Function ◽

Sulfur Mustard ◽

Pulmonary Function Tests ◽

Serum Cytokine ◽

Double Blind ◽

Zataria Multiflora ◽

Function Tests ◽

Double Blind Clinical Trial ◽

Cytokine Levels

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A double-blind, randomized, placebo-controlled clinical trial on the effect of carvacrol on serum cytokine levels and pulmonary function tests in sulfur mustard induced lung injury

Cytokine ◽

10.1016/j.cyto.2018.07.031 ◽

2019 ◽

Vol 113 ◽

pp. 311-318 ◽

Cited By ~ 4

Author(s):

Mohammad Reza Khazdair ◽

Mohammad Hossein Boskabady

Keyword(s):

Clinical Trial ◽

Lung Injury ◽

Pulmonary Function ◽

Sulfur Mustard ◽

Pulmonary Function Tests ◽

Controlled Clinical Trial ◽

Serum Cytokine ◽

Double Blind ◽

Function Tests ◽

Cytokine Levels

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Double-Blind Evaluation of Methylprednisolone Versus Placebo for Acute Asthma Episodes

PEDIATRICS ◽

10.1542/peds.71.4.510 ◽

1983 ◽

Vol 71 (4) ◽

pp. 510-514 ◽

Cited By ~ 2

Author(s):

Gail G. Shapiro ◽

Clifton T. Furukawa ◽

William E. Pierson ◽

Rhonda Gardinier ◽

C. Warren Bierman

Keyword(s):

Placebo Group ◽

Pulmonary Function ◽

Pulmonary Function Tests ◽

Forced Expiratory Volume ◽

Adrenal Function ◽

Double Blind ◽

Function Tests ◽

Forced Expiratory Flow ◽

Blind Manner

Twenty-eight children with persistent bronchospasm after outpatient therapy were treated for eight days with methylprednisolone or placebo in a prerandomized double-blind manner, in addition to treatment with optimal oral bronchodilators. At follow-up visits 1, 7, and 14 days after onset of therapy, a history was taken and physical examination and pulmonary function tests were performed. Initially and on the 14th day, patients underwent cosyntropin tests of adrenal function. Patients kept daily peak flow charts. Both groups improved with time. However, by 24 hours after starting methylprednisolone therapy, the placebo group continued to show reversibility after isoproterenol inhalation whereas the methylprednisolone group did not. By day 7 there were significantly more patients with normal 1-second forced expiratory volume (FEV1) and forced expiratory flow in the middle half of the forced vital capacity (FEF25-75%) in the methylprednisolone group and mean FEF25-75% was significantly higher for this group (P < .02). By day 14, six days after finishing treatment with the study drugs, more patients in the placebo group had residual wheezing, but pulmonary function tests were now similar for the two groups. Although both groups showed a decline in cosyntropin responsiveness on day 14 compared with day 1, there was no difference between the steroid- and placebo-treated patients. This study proves that short-term corticosteroid therapy will accelerate resolution of moderately severe and severe-acute attacks of asthma without significant suppression of adrenal function.

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Oxidative Stress in Smokers Supplemented with Vitamin C

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.69.1.45 ◽

1999 ◽

Vol 69 (1) ◽

pp. 45-51 ◽

Cited By ~ 15

Author(s):

Aghdassi ◽

Royall ◽

Allard

Keyword(s):

Lipid Peroxidation ◽

Vitamin C ◽

Pulmonary Function ◽

Controlled Trial ◽

Pulmonary Function Tests ◽

Plasma Vitamin ◽

Double Blind ◽

Function Tests ◽

Vitamin C Supplementation ◽

Heavy Smokers

The ability of vitamin C supplement to influence lipid peroxidation and pulmonary function tests in healthy smokers was investigated. In this randomized double blind controlled trial, 56 smokers (S) received either 500 mg of vitamin C (C) or placebo (P) daily for 4 weeks. All completed the trial. Both groups were comparable and the number of cigarettes smoked were C: 14.2 ± 1.8 and P: 18.3 ± 2.0 pack-years. Plasma vitamin C concentrations increased significantly (p < 0.005) only in the group supplemented with vitamin C. Lipid peroxidation measured by breath pentane output (BPO) (C: 7.5± 1.4 vs P: 7.0 ± 1.3 pmol.kg–1.min–1) and plasma HPLC-separated malondialdehyde (MDA) (C: 0.58 ± 0.05 vs P: 0.47 ± 0.05 nmol.ml–1) were not significantly different between the 2 groups at baseline and did not change after four weeks of vitamin C supplementation (BPO: C: 5.3 ± 0.9 vs P: 5.5 ± 0.9 pmol.kg–1.min–1; HPLC-MDA: C: 0.50 ± 0.07 vs P: 0.42 ± 0.07 nmol.ml–1). No changes were detected in pulmonary function tests even in heavy smokers. Therefore, 4 week supplementation with 500 mg of vitamin C did not change lipid peroxidation indices and had no effect on pulmonary function tests.

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