An appreciable fraction of carbohydrate-negative (car) mutants of Staphylococcus aureus strains ATCC 14458,778, and S-6 exhibit increased enterotoxin B (SEB) production. In addition, some lac and mtl mutants of these strains also display enhanced SEB formation. All such mutants appear to be point mutations. Mutagen-induced reversions of high SEB producing car, mtl, or lac mutants yield varying amounts of SEB and some clones seem to be restored to the characteristics of the parent type. A few sequentially isolated lac, mtl double mutants of strain 778 elaborate much more or much less SEB than either the lac or the mtl single mutants.
Oral Tolerance to Ovalbumin in Mice: Induction and Long-Term Persistence Unaffected by Staphylococcus aureus Enterotoxin B and Clostridium perfringens Type A Enterotoxin
