Anticoagulant Therapy for Central Nervous System Venous Sinus Thrombosis - A Retrospective Study

Venous sinus thrombosis (VST) should be considered in the differential diagnosis of all unexplained central nervous system disorders of sudden onset. Etiological factors are subclinical forms of several common thrombophilic states occurring together, rather than the typical inherited and rare causes. Diagnosis is often missed because of the heterogeneity in clinical presentation and radiological investigation is essential for the diagnosis. Prognosis depends on the early detection. By correcting the cause, the complications can be prevented.

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The outcomes of pregnant and postpartum patients with cerebral venous sinus thrombosis after anticoagulant therapy

Medicine ◽

10.1097/md.0000000000026360 ◽

2021 ◽

Vol 100 (26) ◽

pp. e26360

Author(s):

Shi-Hui Meng ◽

Jing-Hua Li ◽

Li-Jun Zuo ◽

Li-Min Feng

Keyword(s):

Anticoagulant Therapy ◽

Sinus Thrombosis ◽

Cerebral Venous Sinus Thrombosis ◽

Venous Sinus ◽

Venous Sinus Thrombosis

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Incidence of cerebral venous sinus thrombosis in adults in Germany – a retrospective study using health claims data

10.21203/rs.3.rs-428469/v1 ◽

2021 ◽

Author(s):

Josephine Jacob ◽

Robert Klamroth ◽

Tina Ploner ◽

Thomas Harder ◽

Judith Koch ◽

...

Keyword(s):

Retrospective Study ◽

Claims Data ◽

Viral Vector ◽

Sinus Thrombosis ◽

Cerebral Venous Sinus Thrombosis ◽

Venous Sinus ◽

Health Claims ◽

Venous Sinus Thrombosis ◽

Health Claims Data

Abstract In March 2021 several cases of cerebral venous sinus thrombosis (CVST) accompanied by thrombocytopenia were reported that occurred within two weeks after immunization with a viral vector-based COVID-19 vaccine. This study aimed to assess the background incidence of CVST and CVST with concurrent thrombocytopenia in adults using anonymized claims data from 2015-2019 in Germany. The average annual CVST incidence was 1.9 per 100,000 individuals (95%-CI 1.4-2.3). It was higher in women aged 18 to 59 years as compared to same-aged men. In contrast to the currently reported immunization-related cases, CVST was rarely associated with concurrent thrombocytopenia or death.

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Cortical vein thrombosis in adult patients of cerebral venous sinus thrombosis correlates with poor outcome and brain lesions: a retrospective study

BMC Neurology ◽

10.1186/s12883-017-0995-y ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 6

Author(s):

Jiahui Liang ◽

Hongbing Chen ◽

Zhuhao Li ◽

Shaofu He ◽

Boning Luo ◽

...

Keyword(s):

Retrospective Study ◽

Sinus Thrombosis ◽

Cerebral Venous Sinus Thrombosis ◽

Brain Lesions ◽

Adult Patients ◽

Venous Sinus ◽

Venous Sinus Thrombosis ◽

Cortical Vein ◽

Vein Thrombosis ◽

Cortical Vein Thrombosis

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Incidence of cerebral venous sinus thrombosis in adults in Germany – a retrospective study using health claims data

10.21203/rs.3.rs-428469/v2 ◽

2021 ◽

Author(s):

Josephine Jacob ◽

Robert Klamroth ◽

Tina Ploner ◽

Thomas Harder ◽

Judith Koch ◽

...

Keyword(s):

Retrospective Study ◽

Claims Data ◽

Viral Vector ◽

Sinus Thrombosis ◽

Cerebral Venous Sinus Thrombosis ◽

Venous Sinus ◽

Health Claims ◽

Venous Sinus Thrombosis ◽

Health Claims Data

Abstract In March 2021 several cases of cerebral venous sinus thrombosis (CVST) accompanied by thrombocytopenia were reported that occurred within two weeks after immunization with a viral vector-based COVID-19 vaccine. This study aimed to assess the background incidence of CVST and CVST with concurrent thrombocytopenia in adults using anonymized claims data from 2015-2019 in Germany. The average annual CVST incidence was 1.9 per 100,000 individuals (95%-CI 1.4-2.3). It was higher in women aged 18 to 59 years as compared to same-aged men. In contrast to the currently reported immunization-related cases, CVST was rarely associated with concurrent thrombocytopenia or death.

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Visual loss after long-haul flight

European Journal of Ophthalmology ◽

10.1177/1120672120965499 ◽

2020 ◽

pp. 112067212096549

Author(s):

Nurliyana Ain Abdul Ghani ◽

Azlindarita Aisyah Binti Mohd Abdullah ◽

Shamsiah Abdul Hamid ◽

Muhamad Yazli Yuhana ◽

Norlina Ramli

Keyword(s):

Magnetic Resonance ◽

Anticoagulant Therapy ◽

Visual Loss ◽

Sinus Thrombosis ◽

Complete Recovery ◽

Transverse Sinus ◽

Cerebral Venous Sinus Thrombosis ◽

Venous Sinus ◽

Medical Illness ◽

Venous Sinus Thrombosis

Background: Deep cerebral venous sinus thrombosis is a reversible yet potentially serious thromboembolic event. A number of reports suggest a relationship between long-haul flights and thromboembolic events, mainly deep venous thrombosis (DVT) and pulmonary embolism (PE). It is rarely reported to cause deep cerebral venous sinus thrombosis. We report a case of a bilateral papilledema after long-haul flight secondary to deep cerebral venous sinus thrombosis with subsequent complete recovery post corticosteroid and anticoagulant therapy. Case: A case of a 21-year-old woman with no known medical illness who presented with gradual painless bilateral visual loss is described. She had a history of travelling on a long-haul flight 3 weeks prior to presentation. Examination showed presence of bilateral papilloedema, no vitritis, choroiditis and retinitis. Blood investigations showed raised international normalised ratio (INR). Otherwise, workup for infectious causes of optic disc swelling, connective tissue disease screening were normal. Magnetic resonance imaging (MRI) and magnetic resonance venography (MRV) of the brain showed loss of flow signal in the right transverse sinus and the left sigmoid sinus. Blood workup for preexisting hypercoagulable state was normal. She was diagnosed with deep cerebral venous sinus thrombosis and showed complete recovery with oral corticosteroid and anticoagulant therapy. Conclusion: Deep cerebral venous sinus thrombosis is a potentially serious consequence of long-haul flights. A high index of suspicion along with radiological techniques is needed for early detection and initiation of anticoagulation for this reversible condition.

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