scholarly journals Inflammation Mediated Down-Regulation of Hepatobiliary Transporters Contributes to Intrahepatic Cholestasis and Liver Damage in Murine Biliary Atresia

2009 ◽  
Vol 66 (4) ◽  
pp. 380-385 ◽  
Author(s):  
Huiqi Yang ◽  
Torsten Plösch ◽  
Ton Lisman ◽  
Annette S H Gouw ◽  
Robert J Porte ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Liver Damage ◽  
Intrahepatic Cholestasis ◽  
Down Regulation

Neonatal Intrahepatic Cholestasis Caused by Citrin Deficiency Differentiated from Biliary Atresia

2015 ◽  
Vol 26 (03) ◽  
pp. 255-259 ◽  
Author(s):  
Wei-Jue Xu ◽  
Guo-Li Tian ◽  
Ting Zhang ◽  
Zhibao Lv ◽  
Zhenhua Gong
Keyword(s):  
Biliary Atresia ◽  
Intrahepatic Cholestasis ◽  
Citrin Deficiency

scholarly journals Pharmacological protection of the detoxification activity of animals’ liver with the help of phospholipid and polysaccharide nature substances complex

2020 ◽  
Vol 175 ◽  
pp. 03002
Author(s):  
Elena Kuzminova ◽  
Marina Semenenko ◽  
Evgeny Dolgov ◽  
Serik Kanatbaev ◽  
Andrey Abramov
Keyword(s):  
Body Weight ◽  
Protein Synthesis ◽  
Liver Damage ◽  
Sodium Nitrate ◽  
Intrahepatic Cholestasis ◽  
Clinical Manifestations ◽  
Laboratory Animals ◽  
Mineral Fertilizers ◽  
Nitrogen Compounds ◽  
Chemical Pollutants

Currently, among chemical pollutants a significant danger to the health of animals and humans represent oxygen-containing nitrogen compounds nitrates and nitrites, which are widely used as mineral fertilizers. The article presents data on the study of chronic nitrate intoxication, reproduced in laboratory animals and its pharmacological correction with a complex of substances of phospholipid and polysaccharide nature. The introduction of sodium nitrate to non-linear rats for 30 days at a dose of 3.8 mg per animal leads to the development of intoxication in rats with dominant signs of liver damage. On this background, the use of the complex of beet fiber and rapeseed lecithin leads to a weakening of nitrate toxicosis, which is demonstrated by an increase in rats’ body weight, weakening of the clinical manifestations of intoxication, a decrease in cytolytic syndrome, intrahepatic cholestasis and impaired protein synthesis function of liver.

Up and down regulation of apoptosis in hepatitis C virus-related liver damage

2004 ◽  
Vol 41 (5) ◽  
pp. 883-885 ◽  
Author(s):  
Fabio Farinati ◽  
Romilda Cardin ◽  
Marina Bortolami ◽  
Massimo Rugge
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Damage ◽  
Down Regulation

scholarly journals COVID-19 is a risk factor for severe liver damage for patients with intrahepatic cholestasis of pregnancy: a case report

2020 ◽  
Author(s):  
Ling Ai ◽  
Jia Wei ◽  
Shaofang Wang ◽  
Xi Tan ◽  
Li Yan ◽  
...  
Keyword(s):  
Risk Factor ◽  
Liver Damage ◽  
Intrahepatic Cholestasis ◽  
Termination Of Pregnancy ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Severe Liver ◽  
Case Presentation ◽  
Severe Liver Damage ◽  
Wbc Count ◽  
Cholestasis Of Pregnancy

Abstract Background: Patients with intrahepatic cholestasis of pregnancy (ICP) may present with slight liver damage. In the global outbreak, the number of pregnant women infected with coronavirus disease 2019 (COVID-19) is increasing. For the pregnant patients with ICP, COVID-19 may cause severe liver damage.Case presentation: A 31-year-old pregnant woman was admitted with fever and respiratory symptoms to Tongji Hospital in Wuhan amid the outbreak of COVID-19. Her chest CT scan showed an infection with viral pneumonia as multiple ground glass opacities in both lungs were spotted. Laboratory tests revealed increased white blood cell (WBC) count and decreased lymphocyte count. The levels of serum total bile acid (TBA) were highly elvated. So were the indices of liver function, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), alkaline phosphatase (AKP), 𝛄-glutamyltranspeptidase (𝛄-GT), and lactate dehydrogenase (LDH). The patient was later diagnosed of COVID-19 with comorbid ICP, presenting severe liver damage. Through timely termination of pregnancy and effective treatments, the prognoses of the patient and the fetus were well improved.Conclusions: This case highlights that COVID-19 may be a risk factor of severe liver damage for patients with ICP.Timely termination of pregnancy and effective symptomatic treatments are helpful to improve the progonosis.

Biliary Atresia

PEDIATRICS ◽  
1981 ◽  
Vol 68 (6) ◽  
pp. 896-898
Author(s):  
R. Peter Altman
Keyword(s):  
Biliary Atresia ◽  
Intrahepatic Cholestasis ◽  
Bile Ducts ◽  
Aggressive Approach ◽  
Diagnostic Studies

Since Kasai et al1 demonstrated convincingly that biliary atresia was a treatable, and in some instances curable condition, the approach to the jaundiced infant has changed dramatically. Efforts to identify infants with this disease were greatly accelerated as the "hands off" philosophy, predicated on the assumption that attempts to correct biliary atresia would be futile, gave way to a more aggressive approach. Inevitably, this led to a proliferation of diagnostic studies, each attempting to discriminate between intrahepatic cholestasis and extrahepatic atresia of the bile ducts. Many of these studies purported to be helpful are, in fact, of little value. Undoubtedly, this is because biliary atresia is not exclusively a condition afflicting the bile ducts, ultimately resulting in obstruction.

VIRAL HEPATITIS IN EARLY INFANCY

PEDIATRICS ◽  
1954 ◽  
Vol 13 (5) ◽  
pp. 447-453
Author(s):  
ROLAND B. SCOTT ◽  
WARREN WILKINS ◽  
ALTHEA KESSLER
Keyword(s):  
Differential Diagnosis ◽  
Biliary Atresia ◽  
Viral Hepatitis ◽  
Surgical Procedures ◽  
Liver Damage ◽  
Clinical Picture ◽  
Young Infant ◽  
Early Infancy ◽  
Microscopic Findings ◽  
Serum Type

Three fatal cases of hepatitis with jaundice are reported in siblings with onset at ages of 4 weeks, 1 week, and 4 months, and death at 3 months, 4 months and 9 months, respectively. Microscopic findings in postmortem sections of the liver were consistent with a diagnosis of viral hepatitis. From known data available it was probably of the homologous serum type. The mother and two living siblings exhibited laboratory evidence of liver damage. Congenital viral hepatitis may simulate the clinical picture of biliary atresia. Failure to include a consideration of viral hepatitis in the differential diagnosis of icterus in the very young infant may have serious consequences since these cases do not withstand surgical procedures, such as exploratory laparatomy, very well.

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