Formulation and optimization of controlled release mucoadhesive tablets of atenolol using response surface methodology

The objective of the current study was to formulate mucoadhesive controlled release matrix tablets of flurbiprofen and to optimize its drug release profile and bioadhesion using response surface methodology. Tablets were prepared via a direct compression technique and evaluated for in vitro dissolution parameters and bioadhesive strength. A central composite design for two factors at five levels each was employed for the study. Carbopol 934 and sodium carboxymethylcellulose were taken as independent variables. Fourier transform infrared (FTIR) spectroscopy studies were performed to observe the stability of the drug during direct compression and to check for a drug-polymer interaction. Various kinetic models were applied to evaluate drug release from the polymers. Contour and response surface plots were also drawn to portray the relationship between the independent and response variables. Mucoadhesive tablets of flurbiprofen exhibited non-Fickian drug release kinetics extending towards zero-order, with some formulations (F3, F8, and F9) reaching super case II transport, as the value of the release rate exponent (n) varied between 0.584 and 1.104. Polynomial mathematical models, generated for various response variables, were found to be statistically significant (P<0.05). The study also helped to find the drug's optimum formulation with excellent bioadhesive strength. Suitable combinations of two polymers provided adequate release profile, while carbopol 934 produced more bioadhesion.

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Response surface methodology to obtain naproxen controlled release tablets from its microspheres with Eudragit L100-55

Journal of Microencapsulation ◽

10.1080/02652040110055630 ◽

2001 ◽

Vol 18 (5) ◽

pp. 651-662 ◽

Cited By ~ 13

Author(s):

A. A. Zaghloul, S. R. Vaithiyalinga

Keyword(s):

Response Surface Methodology ◽

Controlled Release ◽

Response Surface ◽

Eudragit L100 ◽

Controlled Release Tablets

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Design and optimization of diclofenac sodium controlled release solid dispersions by response surface methodology

Indian Journal of Pharmaceutical Sciences ◽

10.4103/0250-474x.40327 ◽

2008 ◽

Vol 70 (1) ◽

pp. 22 ◽

Cited By ~ 28

Author(s):

HN Shivakumar ◽

BG Desai ◽

G Deshmukh

Keyword(s):

Response Surface Methodology ◽

Controlled Release ◽

Response Surface ◽

Solid Dispersions ◽

Diclofenac Sodium ◽

Design And Optimization

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Optimization of Cellulose-Based Hydrogel Synthesis Using Response Surface Methodology

Biointerface Research in Applied Chemistry ◽

10.33263/briac126.71367146 ◽

2021 ◽

Vol 12 (6) ◽

pp. 7136-7146

Keyword(s):

Response Surface Methodology ◽

Controlled Release ◽

Response Surface ◽

Chemical Crosslinking ◽

Swelling Ratio ◽

Synthesis Parameters ◽

Hydrogel Synthesis ◽

Cellulose Hydrogel ◽

Agricultural Applications ◽

Optimized Conditions

Synthesis parameters have a significant effect on the properties of cellulose hydrogel. This study aimed to investigate the effects of synthesis parameters, e.g., the cellulose and crosslinkers concentration, on the hydrogels' swelling ratio under both heating and freezing gelation conditions, respectively. Cellulose hydrogels were prepared from wastepaper by the chemical crosslinking method by using epichlorohydrin ECH as a crosslinker. The effects of the synthesis parameters were compared and optimized by response surface methodology (RSM). Synthesized cellulose-based hydrogels under optimized conditions demonstrated an excellent swelling ratio of around 2800%. The optimum swelling ratio of 2467.72% was achieved from the experiment under the heating gelation condition. Thus the synthesized cellulose hydrogels are promising water-saving materials or controlled-release fertilizer carriers for sustainable horticultural and agricultural applications.

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