A Novel Beads-Based Dissolution Method for the In Vitro Evaluation of Extended Release HPMC Matrix Tablets and the Correlation with the In Vivo Data

<p>Investigation of <em>in vitro/in vivo</em> behaviour of extended release tablets containing solid dispersions of Atorvastatin is the focus of the present research work. Atorvastatin trilayer matrix tablets were prepared by direct compression method and consisted of middle active layer with different grades of hydroxypropylmethylcellulose (HPMC), ethyl cellulose and Carbopol 934P. Barrier layers are prepared with hydrophobic polymers carnauba wax and xanthan gum. Based on the evaluation parameters, drug dissolution profile and release order kinetics HF16 was found to be optimized formulation. The developed drug delivery system provided prolonged drug release rates over a period of 24 h. The release profile of the optimized formulation (HF16) was described by the Zero-order and best fitted to Higuchi model. FTIR confirmed that there was no chemical interaction between drug and excipients used in the formulation. . In vivo bioavailability studies were conducted for optimized formulation HF16 and reference standard. The optimized formulation of Atorvastatin trilayer matrix tablet was shown significant plasma concentration with extended release and maintained for 24 hrs with patient compliance by reducing the dosage frequency, when compared with reference standard. </p>

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Development of a new single unit dosage form of propranolol HCl extended release non-effervescent floating matrix tablets: In vitro and in vivo evaluation

Journal of Applied Pharmaceutical Science ◽

10.7324/japs.2016.60517 ◽

2016 ◽

pp. 112-118 ◽

Cited By ~ 1

Author(s):

Rajendra Jadi ◽

Ramesh Bomma ◽

Velmurugan Sellappan

Keyword(s):

Single Unit ◽

Dosage Form ◽

Extended Release ◽

Matrix Tablets ◽

In Vivo Evaluation ◽

Propranolol Hcl

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Design and in vitro/in vivo evaluation of extended release matrix tablets of nateglinide

Journal of Young Pharmacists ◽

10.1016/j.jyp.2013.11.003 ◽

2013 ◽

Vol 5 (4) ◽

pp. 167-172 ◽

Cited By ~ 4

Author(s):

Pushkar R. Sharma ◽

Shaila A. Lewis

Keyword(s):

Extended Release ◽

Matrix Tablets ◽

In Vivo Evaluation

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Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies

Polymers ◽

10.3390/polym11071095 ◽

2019 ◽

Vol 11 (7) ◽

pp. 1095 ◽

Cited By ~ 6

Author(s):

Zara Khizer ◽

Muhammad R. Akram ◽

Rai M. Sarfraz ◽

Jorabar Singh Nirwan ◽

Samia Farhaj ◽

...

Keyword(s):

Drug Release ◽

Surface Texture ◽

Drug Absorption ◽

Extended Release ◽

Matrix Tablets ◽

Hydrophilic Matrices ◽

3D Printed ◽

3D Surface Texture

Hydroxypropyl methyl cellulose, HPMC, a hydrophilic polymer, is widely used for the development of extended release hydrophilic matrices and it is also considered as a good contender for the fabrication of 3D printing of matrix tablets. It is often combined with plasticisers to enable extrusion. The aim of the current project was to develop plasticizer-free 3D printed hydrophilic matrices using drug loaded filaments prepared via HME to achieve an in vitro (swelling, erosion and drug release) and in vivo (drug absorption) performance which is analogous to hydrophilic matrix tablets developed through conventional approaches. Additionally, the morphology of the printed tablets was studied using quantitative 3D surface texture studies and the porosity calculated. Filaments were produced successfully and used to produce matrix tablets with acceptable drug loading (95–105%), mechanical and surface texture properties regardless of the employed HPMC grade. The viscosity of HPMC had a discernible impact on the swelling, erosion, HPMC dissolution, drug release and pharmacokinetic findings. The highest viscosity grade (K100M) results in higher degree of swelling, decreased HPMC dissolution, low matrix erosion, decreased drug release and extended drug absorption profile. Overall, this study demonstrated that the drug loaded (glipizide) filaments and matrix tablets of medium to high viscosity grades of HPMC, without the aid of plasticisers, can be successfully prepared. Furthermore, the in vitro and in vivo studies have revealed the successful fabrication of extended release matrices.

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Extended release matrix tablets of Stavudine: Formulation and in vitro evaluation

Asian Journal of Pharmaceutics ◽

10.4103/0973-8398.72122 ◽

2010 ◽

Vol 4 (3) ◽

pp. 219 ◽

Cited By ~ 4

Author(s):

M Saravanakumar ◽

N Venkateswaramurthy ◽

D Dhachinamoorthi ◽

P Perumal

Keyword(s):

Extended Release ◽

Matrix Tablets ◽

In Vitro Evaluation

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Formulation development and Stability Studies of Meropenem Extended-Release matrix Tablets

International Journal of Innovative Science & Technology ◽

10.22270/ijist.v3i4.18 ◽

2018 ◽

pp. 1-12

Author(s):

Mohini Sihare ◽

Rajendra Chouksey

Keyword(s):

Drug Release ◽

Extended Release ◽

Methyl Cellulose ◽

Film Coating ◽

Matrix Tablets ◽

Formulation Development ◽

High Concentration ◽

Drug Diffusion

The aim of this research was to develop a new hydrophilic matrix system containing meropenem (MEX). Extended-release tablets are usually intended for once-a-day administration with benefits to the patient and lower discontinuation of the therapy. Formulations were developed with hydroxyl propyl methyl cellulose or poly (ethylene oxide) as hydrophilic polymers, with different molecular weights (MWs) and concentrations (20 and 30%). The tablets were found to be stable (6 months at 40 ± 2°C and 75± 5% relative humidity), and the film-coating process is recommended to avoid MEX photo-degradation. The dissolution profiles demonstrated an extended-release of MEX for all developed formulations. Dissolution curves analyzed using the Korsmeyer exponential equation showed that drug release was controlled by both drug diffusion and polymer relaxation or erosion mechanisms. A more erosion controlled system was obtained for the formulations containing lower MW and amount of polymer. With the increase in both MW and amount of polymer in the formulation, the gel layer became stronger, and the dissolution was more drug-diffusion dependent. Formulations containing intermediate MW polymers or high concentration (30%) of low MW polymers demonstrated a combination of extended and complete in vitro drug release. This way, these formulations could provide an increased bioavailability in vivo.

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Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets

BioMed Research International ◽

10.1155/2013/716736 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

Paulo Renato Oliveira ◽

Cassiana Mendes ◽

Lilian Klein ◽

Maximiliano da Silva Sangoi ◽

Larissa Sakis Bernardi ◽

...

Keyword(s):

Drug Release ◽

Extended Release ◽

Film Coating ◽

Matrix Tablets ◽

Formulation Development ◽

High Concentration ◽

Drug Diffusion ◽

Erosion Mechanisms

The aim of this research was to develop a new hydrophilic matrix system containing norfloxacin (NFX). Extended-release tablets are usually intended for once-a-day administration with benefits to the patient and lower discontinuation of the therapy. Formulations were developed with hydroxypropylmethylcellulose or poly(ethylene oxide) as hydrophilic polymers, with different molecular weights (MWs) and concentrations (20 and 30%). The tablets were found to be stable (6 months at40±2°C and75±5% relative humidity), and the film-coating process is recommended to avoid NFX photodegradation. The dissolution profiles demonstrated an extended-release of NFX for all developed formulations. Dissolution curves analyzed using the Korsmeyer exponential equation showed that drug release was controlled by both drug diffusion and polymer relaxation or erosion mechanisms. A more erosion controlled system was obtained for the formulations containing lower MW and amount of polymer. With the increase in both MW and amount of polymer in the formulation, the gel layer became stronger, and the dissolution was more drug-diffusion dependent. Formulations containing intermediate MW polymers or high concentration (30%) of low MW polymers demonstrated a combination of extended and complete in vitro drug release. This way, these formulations could provide an increased bioavailability in vivo.

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