scholarly journals Formulation Development and In Vitro Evaluation of Propranolol Hydrochloride Extended Release Matrix Tablets

2017 ◽  
Keyword(s):  
Extended Release ◽  
Matrix Tablets ◽  
Propranolol Hydrochloride ◽  
Formulation Development ◽  
In Vitro Evaluation

scholarly journals A Novel Beads-Based Dissolution Method for the In Vitro Evaluation of Extended Release HPMC Matrix Tablets and the Correlation with the In Vivo Data

2012 ◽  
Vol 15 (1) ◽  
pp. 267-277 ◽  
Author(s):  
Uroš Klančar ◽  
Boštjan Markun ◽  
Saša Baumgartner ◽  
Igor Legen
Keyword(s):  
Extended Release ◽  
Matrix Tablets ◽  
In Vitro Evaluation ◽  
Dissolution Method

Formulation development and in-vitro evaluation of potassium chloride extended-release tablets

2020 ◽  
Vol 13 (10) ◽  
pp. 4697
Author(s):  
P. Shanmugapriya ◽  
K. Manivel ◽  
R. Selvamuthukumar ◽  
R. Sanilkumar
Keyword(s):  
Potassium Chloride ◽  
Extended Release ◽  
Formulation Development ◽  
In Vitro Evaluation

scholarly journals Formulation, Development, and Optimization of Anti- Hypertensive Nisoldipine Extended-Release Tablet Formulation

2020 ◽  
Vol 5 (03) ◽  
pp. 37-44
Author(s):  
Kukkadapu Pavan Kumar ◽  
Katta Sunand ◽  
Nerella Mounika ◽  
Mohammed Abdul Samad ◽  
A. Madhu Babu ◽  
...  
Keyword(s):  
Drug Release ◽  
Extended Release ◽  
Aqueous Solubility ◽  
Cellular Membrane ◽  
Tablet Formulation ◽  
Water Soluble ◽  
Matrix Tablets ◽  
Formulation Development ◽  
Release Tablet

A drug molecule has to be water-soluble to be readily delivered to the cellular membrane. Many drugs are waterinsoluble, which creates numerous problems in the development of dosage forms. Controlled drug delivery formulation releases the drug with controlled kinetics for days and months, reducing the frequency of dosing, minimizing side effects, and improving patient compliance. Nisoldipine is a calcium channel antagonist that is indicated for the treatment of hypertension with very poor aqueous solubility. Thus, there is a need to improve the rate of drug release. Hence, the study was carried out to design, formulate and evaluate sustained-release tablet formulation of nisoldipine. Nisoldipine controlled release matrix tablets were prepared by roll compaction method. Preformulation studies have confirmed the purity and compatibility of drug with excipients used in the formulation. Pre-compression studies have confirmed the stability of formulation blends for compression. All the prepared formulations were evaluated for various physical and compression parameters such as bulk and tapped density, hardness, friability, and in vitro drug release studies. The results of drug release from prepared compressed nisoldipine extended-release tablets were found to be within the desired range.

Extended release matrix tablets of Stavudine: Formulation and in vitro evaluation

2010 ◽  
Vol 4 (3) ◽  
pp. 219 ◽  
Author(s):  
M Saravanakumar ◽  
N Venkateswaramurthy ◽  
D Dhachinamoorthi ◽  
P Perumal
Keyword(s):  
Extended Release ◽  
Matrix Tablets ◽  
In Vitro Evaluation

scholarly journals Formulation development and Stability Studies of Meropenem Extended-Release matrix Tablets

2018 ◽  
pp. 1-12
Author(s):  
Mohini Sihare ◽  
Rajendra Chouksey
Keyword(s):  
Drug Release ◽  
Extended Release ◽  
Methyl Cellulose ◽  
Film Coating ◽  
Matrix Tablets ◽  
Formulation Development ◽  
High Concentration ◽  
Drug Diffusion

The aim of this research was to develop a new hydrophilic matrix system containing meropenem (MEX). Extended-release tablets are usually intended for once-a-day administration with benefits to the patient and lower discontinuation of the therapy. Formulations were developed with hydroxyl propyl methyl cellulose or poly (ethylene oxide) as hydrophilic polymers, with different molecular weights (MWs) and concentrations (20 and 30%). The tablets were found to be stable (6 months at 40 ± 2°C and 75± 5% relative humidity), and the film-coating process is recommended to avoid MEX photo-degradation. The dissolution profiles demonstrated an extended-release of MEX for all developed formulations. Dissolution curves analyzed using the Korsmeyer exponential equation showed that drug release was controlled by both drug diffusion and polymer relaxation or erosion mechanisms. A more erosion controlled system was obtained for the formulations containing lower MW and amount of polymer. With the increase in both MW and amount of polymer in the formulation, the gel layer became stronger, and the dissolution was more drug-diffusion dependent. Formulations containing intermediate MW polymers or high concentration (30%) of low MW polymers demonstrated a combination of extended and complete in vitro drug release. This way, these formulations could provide an increased bioavailability in vivo.

scholarly journals Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Paulo Renato Oliveira ◽  
Cassiana Mendes ◽  
Lilian Klein ◽  
Maximiliano da Silva Sangoi ◽  
Larissa Sakis Bernardi ◽  
...  
Keyword(s):  
Drug Release ◽  
Extended Release ◽  
Film Coating ◽  
Matrix Tablets ◽  
Formulation Development ◽  
High Concentration ◽  
Drug Diffusion ◽  
Erosion Mechanisms

The aim of this research was to develop a new hydrophilic matrix system containing norfloxacin (NFX). Extended-release tablets are usually intended for once-a-day administration with benefits to the patient and lower discontinuation of the therapy. Formulations were developed with hydroxypropylmethylcellulose or poly(ethylene oxide) as hydrophilic polymers, with different molecular weights (MWs) and concentrations (20 and 30%). The tablets were found to be stable (6 months at40±2°C and75±5% relative humidity), and the film-coating process is recommended to avoid NFX photodegradation. The dissolution profiles demonstrated an extended-release of NFX for all developed formulations. Dissolution curves analyzed using the Korsmeyer exponential equation showed that drug release was controlled by both drug diffusion and polymer relaxation or erosion mechanisms. A more erosion controlled system was obtained for the formulations containing lower MW and amount of polymer. With the increase in both MW and amount of polymer in the formulation, the gel layer became stronger, and the dissolution was more drug-diffusion dependent. Formulations containing intermediate MW polymers or high concentration (30%) of low MW polymers demonstrated a combination of extended and complete in vitro drug release. This way, these formulations could provide an increased bioavailability in vivo.

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