Chronic stimulation of the pituitary-adrenal axis in rats by interleukin-1 beta infusion: in vivo and in vitro studies

Endocrinology ◽  
1992 ◽  
Vol 130 (3) ◽  
pp. 1153-1164 ◽  
Author(s):  
C. G. Sweep
Keyword(s):  
Interleukin 1 ◽  
In Vitro Studies ◽  
Interleukin 1 Beta ◽  
Chronic Stimulation ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis ◽  
Stimulation Of

Chronic stimulation of the pituitary-adrenal axis in rats by interleukin-1 beta infusion: in vivo and in vitro studies.

Endocrinology ◽  
1992 ◽  
Vol 130 (3) ◽  
pp. 1153-1164
Author(s):  
C G Sweep ◽  
M J van der Meer ◽  
A R Hermus ◽  
A G Smals ◽  
J W van der Meer ◽  
...  
Keyword(s):  
Interleukin 1 ◽  
In Vitro Studies ◽  
Interleukin 1 Beta ◽  
Chronic Stimulation ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis ◽  
Stimulation Of

Effect of fluoxetine on interleukin-1 beta in rat brain – in vivo and in vitro studies

2010 ◽  
Vol 62 ◽  
pp. 57
Author(s):  
Ewa Obuchowicz ◽  
Anna Bielecka ◽  
Agnieszka Prymus ◽  
Łukasz Drzyzga ◽  
Monika Paul-Samojedny ◽  
...  
Keyword(s):  
Rat Brain ◽  
Interleukin 1 ◽  
In Vitro Studies ◽  
Interleukin 1 Beta

Cytokines mediate protective stimulation of glucocorticoid output during autoimmunity: involvement of IL-1

1998 ◽  
Vol 275 (4) ◽  
pp. R1146-R1151 ◽  
Author(s):  
Adriana Del Rey ◽  
Isabel Klusman ◽  
Hugo O. Besedovsky
Keyword(s):  
Basic Protein ◽  
Interleukin 1 ◽  
Endocrine Response ◽  
Autoimmune Encephalomyelitis ◽  
Lewis Rats ◽  
Pituitary Adrenal Axis ◽  
Experimental Autoimmune ◽  
Stimulation Of

Endogenous glucocorticoid levels are increased during experimental autoimmune encephalomyelitis (EAE) in Lewis rats. Although this endocrine response is essential for survival, the mechanism that triggers the stimulation of glucocorticoid output during the disease remains unknown. We report here that 1) after immunization with the encephalitogenic antigen myelin basic protein (MBP), increased blood glucocorticoid levels are not only observed in Lewis rats, but also in PVG rats, which do not develop EAE; 2) immune cells obtained from animals with EAE and stimulated in vitro with MBP produced mediators that increased glucocorticoid levels when administered to naive recipients; and 3) acute in vivo blockade of interleukin-1 (IL-1) receptors inhibited, to a large extent, the increase in corticosterone levels during EAE. These results show that the increase in corticosterone levels after immunization with MBP can be dissociated from the stress of the paralytic attack that characterizes EAE. Furthermore, they indicate that an endocrine response, which is decisive for the prevention or moderation of EAE, is mainly the result of the stimulation of the hypothalamic-pituitary-adrenal axis by cytokines produced during the immune response that induces the autoimmune disease.

Is the Success of Cefazolin plus Ertapenem in Methicillin-Susceptible Staphylococcus aureus Bacteremia Based on Release of Interleukin 1-beta?

2022 ◽  
Author(s):  
Dan Smelter ◽  
Mary Hayney ◽  
George Sakoulas ◽  
Warren Rose
Keyword(s):  
Staphylococcus Aureus ◽  
Peripheral Blood ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Blood Monocytes ◽  
Salvage Regimen ◽  
Peripheral Blood Monocytes ◽  
Staphylococcus Aureus Bacteremia

Cefazolin and ertapenem has been shown to be an effective salvage regimen for refractory methicillin-susceptible Staphylococcus aureus bacteremia. Our findings suggest cefazolin plus ertapenem in vitro stimulates interleukin-1β release from peripheral blood monocytes both with and without S. aureus presence. This IL-1β augmentation was primarily driven by ertapenem. These findings support further exploration of cefazolin plus ertapenem in MSSA bacteremia and may partially explain its marked potency in vivo despite modest synergy in vitro .

Aging and dietary modulation of elastase and interleukin-1 beta secretion

1995 ◽  
Vol 268 (1) ◽  
pp. R208-R213 ◽  
Author(s):  
J. G. Cannon ◽  
M. A. Fiatarone ◽  
M. Meydani ◽  
J. Gong ◽  
L. Scott ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Cell Function ◽  
Interleukin 1 ◽  
Lipid Peroxide ◽  
Arachidonic Acid Metabolism ◽  
Interleukin 1 Beta ◽  
Tension Development ◽  
Age Related

Aging is associated with diminished immune function that may stem from alterations in arachidonic acid metabolism and lipid peroxidation. This study sought to determine if dietary modification of fatty acids influenced neutrophil and monocyte secretion after an in vivo inflammatory stress in older human subjects. Volunteers participated in protocols that forced their quadriceps muscles to lengthen during tension development (eccentric stress). These protocols can cause inflammatory foci in the muscle as well as alterations in circulating leukocyte function. In this study, in vivo neutrophil degranulation was assessed by plasma elastase concentrations, and mononuclear cell function was assessed by interleukin-1 beta (IL-1 beta) secretion in vitro. In response to eccentric stress, older subjects (> 60 yr old) taking a placebo had no apparent elastase response, whereas those taking fish oil supplements responded with a 142% increase in plasma elastase (P = 0.011), similar to responses of younger reference subjects (< 33 yr old) taking no supplement. Overall, elastase responses correlated with individual plasma arachidonic acid-to-eicosapentaenoic acid ratios (r = -0.881, P = 0.004). Thus apparent age-related differences in elastase release were reconciled by individual differences in fatty acid nutriture. No significant temporal changes in urinary lipid peroxide excretion or IL-1 beta secretion were observed; however, age-associated differences were found.

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