Is the Success of Cefazolin plus Ertapenem in Methicillin-Susceptible
Staphylococcus aureus
Bacteremia Based on Release of Interleukin 1-beta?
Keyword(s):
Cefazolin and ertapenem has been shown to be an effective salvage regimen for refractory methicillin-susceptible Staphylococcus aureus bacteremia. Our findings suggest cefazolin plus ertapenem in vitro stimulates interleukin-1β release from peripheral blood monocytes both with and without S. aureus presence. This IL-1β augmentation was primarily driven by ertapenem. These findings support further exploration of cefazolin plus ertapenem in MSSA bacteremia and may partially explain its marked potency in vivo despite modest synergy in vitro .
2011 ◽
Vol 140
(1-2)
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pp. 102-109
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Keyword(s):
1991 ◽
Vol 50
(1)
◽
pp. 27-31
◽
Keyword(s):
1992 ◽
Vol 35
(2)
◽
pp. 203-208
◽
Keyword(s):