The Effects of Subdiaphragmatic Vagotomy in Rats With Ventromedial Hypothalamic Obesity

In two independent experiments, complete subdiaphragmatic vagotomy did not prevent the development of the obesity that results from the addition of highly palatable foods to the diet of rats. The vagotomized animals exhibited only a 1-day delay in the onset of overeating, and this only when first exposed to the tasty diet. In independent tests of the functional completeness of the vagotomies, the vagotomized animals failed to overeat or gain excessive weight on a standard laboratory diet following bilaterally parasagittal hypothalamic knife cuts. Thus, hypothalamic knife-cut obesity requires the integrity of the vagus for its full expression, whereas dietary obesity does not.

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Long-term-follow-up of patients with gastric bypass surgery secondary to craniopharyngioma associated hypothalamic obesity

Endocrine Abstracts ◽

10.1530/endoabs.70.ep341 ◽

2020 ◽

Author(s):

Hannes Beiglböck ◽

Paul Fellinger ◽

Tamara Ranzenberger-Haider ◽

Greisa Vila ◽

Anton Luger ◽

...

Keyword(s):

Gastric Bypass ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Hypothalamic Obesity ◽

Long Term Follow Up

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MRI measures of hypothalamic injury are associated with GLP ‐1 receptor agonist treatment response in people with hypothalamic obesity

Diabetes Obesity and Metabolism ◽

10.1111/dom.14366 ◽

2021 ◽

Author(s):

Francisco A. Perez ◽

Clinton Elfers ◽

Jack A. Yanovski ◽

Ashley H. Shoemaker ◽

M. Jennifer Abuzzahab ◽

...

Keyword(s):

Treatment Response ◽

Receptor Agonist ◽

Hypothalamic Obesity ◽

Hypothalamic Injury

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Hypothalamic obesity: Comparison of radio-frequency and electrolytic lesions in weanling rats

Physiology & Behavior ◽

10.1016/0031-9384(89)90175-3 ◽

1989 ◽

Vol 45 (1) ◽

pp. 127-132 ◽

Cited By ~ 3

Author(s):

Bruce M. King ◽

Penny M. Daigrepont ◽

Robert E. Michel ◽

Cari A. Zansler ◽

Jamal I. Ahmed ◽

...

Keyword(s):

Radio Frequency ◽

Hypothalamic Obesity ◽

Weanling Rats ◽

Electrolytic Lesions

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Postabsorptive hyperinsulinemia in rats with subdiaphragmatic vagotomy☆

Physiology & Behavior ◽

10.1016/0031-9384(81)90342-5 ◽

1981 ◽

Vol 27 (3) ◽

pp. 523-527 ◽

Cited By ~ 3

Author(s):

B KING ◽

G PHELPS ◽

L FROHMAN

Keyword(s):

Subdiaphragmatic Vagotomy

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Ultrastructural analysis of the adrenal cortex in rats after bilateral subdiaphragmatic vagotomy

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf00807515 ◽

1977 ◽

Vol 83 (4) ◽

pp. 583-585 ◽

Cited By ~ 2

Author(s):

Yu. K. Eletskii ◽

V. V. Yaglov ◽

N. Ya. Yakovleva

Keyword(s):

Adrenal Cortex ◽

Ultrastructural Analysis ◽

Subdiaphragmatic Vagotomy

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The contribution of the vagus nerve in interleukin-1β-induced fever is dependent on dose

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.2001.280.4.r929 ◽

2001 ◽

Vol 280 (4) ◽

pp. R929-R934 ◽

Cited By ~ 86

Author(s):

Michael K. Hansen ◽

Kevin A. O'Connor ◽

Lisa E. Goehler ◽

Linda R. Watkins ◽

Steven F. Maier

Keyword(s):

Core Body Temperature ◽

Vagal Afferents ◽

Interleukin 1Β ◽

Blood Levels ◽

Low Doses ◽

Neural Pathway ◽

Subdiaphragmatic Vagotomy ◽

Core Body ◽

Neural Signaling ◽

The Brain

It has been suggested that proinflammatory cytokines communicate to the brain via a neural pathway involving activation of vagal afferents by interleukin-1β (IL-1β), in addition to blood-borne routes. In support, subdiaphragmatic vagotomy blocks IL-1β-induced, brain-mediated responses such as fever. However, vagotomy has also been reported to be ineffective. Neural signaling would be expected to be especially important at low doses of cytokine, when local actions could occur, but only very small quantities of cytokine would become systemic. Here, we examined core body temperature after intraperitoneal injections of three doses of recombinat human IL-1β (rh-IL-1β). Subdiaphragmatic vagotomy completely blocked the fever produced by 0.1 μg/kg, only partially blocked the fever produced by 0.5 μg/kg, and had no effect at all on the fever that followed 1.0 μg/kg rh-IL-1β. Blood levels of rh-IL-1β did not become greater than normal basal levels of endogenous rat IL-β until the 0.5-μg/kg dose nor was IL-1β induced in the pituitary until this dose. These results suggest that low doses of intraperitoneal IL-1β induce fever via a vagal route and that dose may account for some of the discrepancies in the literature.

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