SEPARATE NEGATIVE FEEDBACK EFFECTS OF ESTROGEN ON THE PITUITARY AND THE CENTRAL NERVOUS SYSTEM IN THE OVARIECTOMIZED RHESUS MONKEY

Endocrinology ◽  
1983 ◽  
Vol 112 (5) ◽  
pp. 1862-1864 ◽  
Author(s):  
RICHARD F. WEICK ◽  
VACLAV PITELKA ◽  
DAVID L. THOMPSON
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rhesus Monkey ◽  
Negative Feedback ◽  
Feedback Effects ◽  
The Central Nervous System ◽  
Ovariectomized Rhesus Monkey

AIDS and the Central Nervous System: Examining Pathobiology and Testing Therapeutic Strategies in the SIV-Infected Rhesus Monkey

1993 ◽  
Vol 693 (1 Pediatric AID) ◽  
pp. 229-244 ◽  
Author(s):  
LEE E. EIDEN ◽  
DIANNE M. RAUSCH ◽  
ANNA da CUNHA ◽  
ELISABETH A. MURRAY ◽  
MELVYN HEYES ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rhesus Monkey ◽  
Therapeutic Strategies ◽  
The Central Nervous System

scholarly journals Role of GABA-A and GABA-B receptors of the brain in the hypothalamo-pituitary-testicular regulation by the negative feedback mechanism

1995 ◽  
Vol 41 (4) ◽  
pp. 36-38
Author(s):  
Ye. V. V. Naumenko ◽  
A. V. Amikishiyeva ◽  
L. I. Serova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Negative Feedback ◽  
Feedback Mechanism ◽  
Gaba A ◽  
Negative Feedback Mechanism ◽  
The Central Nervous System ◽  
The Brain ◽  
Stimulation Of

The role of gamma-aminobutyric acid (GABA) of the brain and its receptors in the hypothalamo-pituitary-testicular (HPT) regulation by the negative feedback mechanism was for the first time studied in sham-operated and unilaterally castrated adult Wister rats. Increased level of GABA in the central nervous system following an injection of GABA transaminase inhibitor, aminoacetic acid, into the lateral ventricle of the brain was associated with activation of a compensatory increase of testosterone level in the blood, caused by unilateral castration. GABA effect is mediated through the receptors. Muscimol stimulation of GABA-A receptors of the central nervous system activated and their blocking with bicucullin inhibited a compensatory increase of testosterone level in the blood caused by hemicastration. Baclofen stimulation of cerebral GABA-B receptors was associated with an inhibition and their saclofen blocking with stimulation of the level of male sex steroid hormone in the blood following unilateral castration. A conclusion is made about participation of GABAergic mechanisms of the brain in the regulation of HPT function via the negative feedback mechanism

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