EFFECT OF ADMINISTRATION OF HUMAN SERUM THYROXINE-BIND1NG GLOBULIN ON THE DISAPPEARANCE RATES OF THYROID HORMONES IN THE CHICKEN1

Endocrinology ◽  
1961 ◽  
Vol 68 (6) ◽  
pp. 1056-1059 ◽  
Keyword(s):  
Thyroid Hormones ◽  
Human Serum ◽  
Serum Thyroxine

Autoantibodies to thyroxin and triiodothyronine in the immunoglobulin G fraction of serum.

1988 ◽  
Vol 34 (12) ◽  
pp. 2561-2562 ◽  
Author(s):  
L Li Calzi ◽  
S Benvenga ◽  
S Battiato ◽  
F Santini ◽  
F Trimarchi
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Human Serum ◽  
Immunoglobulin G ◽  
Subacute Thyroiditis ◽  
Total Serum ◽  
Graves Disease ◽  
Carrier Proteins ◽  
Weak Binding ◽  
Idiopathic Myxedema

Abstract Thyroid hormone antibodies (THAbs)--i.e., antibodies to thyroxin (T4) and triiodothyronine (T3)--are detected rarely in human serum, where they are searched for, possibly because of a quantitatively minimal interaction between thyroid hormones (the haptens) and serum IgGs (the antibodies). The weak binding could result from these facts: (a) there are already six physiological carrier proteins for thyroid hormones; (b) THAbs usually account for a very small fraction of the total serum IgGs; (c) THAbs may have--as reported in the literature--a relatively low affinity. To ascertain whether THAbs could pass undetected in serum, we measured antibodies to T3 and T4 in both the serum and the corresponding IgG fraction of six normal persons and 45 patients with various thyroid diseases (Graves' disease, idiopathic myxedema, Hashimoto's thyroiditis, subacute thyroiditis, tumors), using radioimmunoprecipitation. The prevalence of antibodies to T4 was 0/51 in both the sera and the IgG fractions; the prevalence of antibodies to T3 was 1/51 in both materials. Because all of the sera that tested THAb negative were confirmed to be so in the THAb assay of the IgG fraction, we conclude that the prevalence of serum THAbs is not underestimated and that autoimmunization against thyroid hormones is really a rare phenomenon.

scholarly journals Binding of thyroid hormones and their analogues to thyroxine-binding globulin in human serum.

1976 ◽  
Vol 251 (21) ◽  
pp. 6489-6494
Author(s):  
S M Snyder ◽  
R R Cavalieri ◽  
I D Goldfine ◽  
S H Ingbar ◽  
E C Jorgensen
Keyword(s):  
Thyroid Hormones ◽  
Human Serum ◽  
Thyroxine Binding Globulin

TRANSPORT OF THYROXINE IN THE SERUM OF VITAMIN A-DEFICIENT RATS

1979 ◽  
Vol 80 (2) ◽  
pp. 223-228 ◽  
Author(s):  
P. HIGUERET ◽  
H. GARCIN
Keyword(s):  
Vitamin A ◽  
Thyroid Hormones ◽  
Vitamin A Deficiency ◽  
Electrophoretic Pattern ◽  
Normal Diet ◽  
Physiological Changes ◽  
Serum Samples ◽  
Serum Thyroxine ◽  
Early Change

Thyroxine (T4) transport in the serum of rats deficient in vitamin A was studied by electrophoresis after incubation of serum samples with radioactive T4. In serum from vitamin A-deficient rats, the amount of radioactivity bound to the prealbumin zone of the electrophoretograms decreased, whereas there was an increase in the amount of radioactivity bound to the albumin zone. The serum from vitamin A-deficient rats subsequently fed a normal diet (repletion experiment) had an electrophoretic pattern similar to that of normal rats. The serum fraction which bound radioactive T4 appeared in the prealbumin rather than the albumin zone. These results suggest that vitamin A deficiency causes an early change in the transport of thyroid hormones in the plasma and a new level of serum thyroxine which may be responsible for the biochemical and physiological changes which occur in vitamin A-deficient rats.

Goitres in rats fed polychlorinated biphenyls

1977 ◽  
Vol 55 (2) ◽  
pp. 288-292 ◽  
Author(s):  
C. H. Bastomsky
Keyword(s):  
Thyroid Hormone ◽  
Polychlorinated Biphenyls ◽  
Thyroid Hormones ◽  
Polychlorinated Biphenyl ◽  
Serum Proteins ◽  
Elevated Serum ◽  
High Serum ◽  
Serum Thyroxine ◽  
Low Serum

Rats fed a polychlorinated biphenyl (PCB) mixture in a high- or low-iodine diet (HID or LID, respectively) for 15 days had thyroid enlargement, low serum thyroxine (T4), and high serum thyrotropin concentrations. Although binding of thyroid hormones to serum proteins was reduced in PCB-fed animals, the free T4 index (reflecting free T4 in serum) was less in these rats. Both serum triiodothyronine (T3) and the free T3 index were elevated in rats fed PCB in HID. LID-maintained rats had elevated serum T3 concentrations but the free T3 index was similar to that in HID-fed rats, owing to enhanced binding of thyroid hormone to serum proteins. Addition of PCB to LID reduced serum T3 levels but did not alter the free T3 index because binding was less. In rats fed HID containing PCB, thyroid 131I uptake was increased.

Rates of dissociation of steroid and thyroid hormones from human serum albumin

1990 ◽  
Vol 37 (2) ◽  
pp. 245-250 ◽  
Author(s):  
Carl M. Mendel ◽  
Martin B. Miller ◽  
Pentti K. Siiteri ◽  
James T. Murai
Keyword(s):  
Human Serum Albumin ◽  
Thyroid Hormones ◽  
Serum Albumin ◽  
Human Serum

scholarly journals A comparison of the binding of thyroid hormones by rat, chicken and human serum

1962 ◽  
Vol 162 (2) ◽  
pp. 358-366 ◽  
Author(s):  
L. M. S. Dubowitz ◽  
N. B. Myant ◽  
C. Osorio
Keyword(s):  
Thyroid Hormones ◽  
Human Serum
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