Some Studies of the Effect of Thyroid Hormone on the RNA Synthesis of the Anterior Pituitary Gland of Rats

Endocrinology ◽  
1968 ◽  
Vol 83 (4) ◽  
pp. 763-768 ◽  
Author(s):  
K. L. LEE ◽  
C. Y. BOWERS ◽  
O. N. MILLER
Keyword(s):  
Thyroid Hormone ◽  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Rna Synthesis ◽  
Anterior Pituitary Gland

THYROID HORMONE REGULATES VASOACTIVE INTESTINAL PEPTIDE (VIP) mRNA LEVELS IN THE RAT ANTERIOR PITUITARY GLAND

Endocrinology ◽  
1989 ◽  
Vol 125 (4) ◽  
pp. 2221-2223 ◽  
Author(s):  
THOMAS P. SEGERSON ◽  
KAREN S.L. LAM ◽  
LUCINDA CACICEDO ◽  
NAOTO MINAMITANI ◽  
J. STEPHEN FINK ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Pituitary Gland ◽  
Vasoactive Intestinal Peptide ◽  
Anterior Pituitary ◽  
Anterior Pituitary Gland ◽  
Mrna Levels

Posttranscriptional regulation of rat growth hormone gene expression: increased message stability and nuclear polyadenylation accompany thyroid hormone depletion

1992 ◽  
Vol 12 (6) ◽  
pp. 2624-2632
Author(s):  
D Murphy ◽  
K Pardy ◽  
V Seah ◽  
D Carter
Keyword(s):  
Growth Hormone ◽  
Thyroid Hormone ◽  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Posttranscriptional Regulation ◽  
Anterior Pituitary Gland ◽  
Growth Hormone Gene ◽  
Gh Gene ◽  
Rat Growth ◽  
Pituitary Glands

In thyroid hormone-depleted rats, the rate of transcription of the growth hormone (GH) gene in the anterior pituitary gland is lower than the rate in euthyroid controls, and there is a corresponding reduction in the abundance of the GH mRNA. Concomitantly, the poly(A) tail of the GH mRNA increases in length. Examination of nuclear RNA from anterior pituitary glands of control and thyroid hormone-depleted rats revealed no difference in the length of pre-mRNAs containing the first and last introns of the GH gene. However, mature nuclear GH RNA is differentially polyadenylated in euthyroid and hypothyroid animals. We suggest that the extent of polyadenylation of the GH transcript is regulated in the cell nucleus concomitant with or subsequent to the splicing of the pre-mRNA. Experiments with anterior pituitary gland explant cultures demonstrated that the GH mRNA from thyroid hormone-depleted rats is more stable than its euthyroid counterpart and that the poly(A) tail may contribute to the differential stability of free GH ribonucleoproteins.

scholarly journals Thyroid Hormone Regulation of Peptidylglycine α-Amidating Monooxygenase Expression in Anterior Pituitary Gland

1990 ◽  
Vol 4 (10) ◽  
pp. 1497-1505 ◽  
Author(s):  
L'Houcine Ouafik ◽  
Victor May ◽  
David W. Saffen ◽  
Betty A. Eipper
Keyword(s):  
Thyroid Hormone ◽  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Anterior Pituitary Gland ◽  
Hormone Regulation

scholarly journals Posttranscriptional regulation of rat growth hormone gene expression: increased message stability and nuclear polyadenylation accompany thyroid hormone depletion.

1992 ◽  
Vol 12 (6) ◽  
pp. 2624-2632 ◽  
Author(s):  
D Murphy ◽  
K Pardy ◽  
V Seah ◽  
D Carter
Keyword(s):  
Growth Hormone ◽  
Thyroid Hormone ◽  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Posttranscriptional Regulation ◽  
Anterior Pituitary Gland ◽  
Growth Hormone Gene ◽  
Gh Gene ◽  
Rat Growth ◽  
Pituitary Glands

In thyroid hormone-depleted rats, the rate of transcription of the growth hormone (GH) gene in the anterior pituitary gland is lower than the rate in euthyroid controls, and there is a corresponding reduction in the abundance of the GH mRNA. Concomitantly, the poly(A) tail of the GH mRNA increases in length. Examination of nuclear RNA from anterior pituitary glands of control and thyroid hormone-depleted rats revealed no difference in the length of pre-mRNAs containing the first and last introns of the GH gene. However, mature nuclear GH RNA is differentially polyadenylated in euthyroid and hypothyroid animals. We suggest that the extent of polyadenylation of the GH transcript is regulated in the cell nucleus concomitant with or subsequent to the splicing of the pre-mRNA. Experiments with anterior pituitary gland explant cultures demonstrated that the GH mRNA from thyroid hormone-depleted rats is more stable than its euthyroid counterpart and that the poly(A) tail may contribute to the differential stability of free GH ribonucleoproteins.

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