scholarly journals Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice*

Endocrinology ◽  
2000 ◽  
Vol 141 (6) ◽  
pp. 2043-2049 ◽  
Author(s):  
Yoshiyuki Sakai ◽  
Marie B. Demay
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Knockout Mice ◽  
Keratinocyte Proliferation ◽  
Proliferation And Differentiation

Vitamin D receptor, a tumor suppressor in skin

2015 ◽  
Vol 93 (5) ◽  
pp. 349-354 ◽  
Author(s):  
Daniel D. Bikle
Keyword(s):  
Vitamin D ◽  
Tumor Suppressor ◽  
Vitamin D Receptor ◽  
Tumor Formation ◽  
Calcium Sensing Receptor ◽  
Keratinocyte Proliferation ◽  
Calcium Sensing ◽  
Damage Repair ◽  
Proliferation And Differentiation ◽  
Active Investigation

Vitamin D and calcium are well-established regulators of keratinocyte proliferation and differentiation. Therefore, it was not a great surprise that deletion of the vitamin D receptor (VDR) should predispose the skin to tumor formation, and that the combination of deleting both the VDR and calcium sensing receptor (CaSR) should be especially pro-oncogenic. In this review I have examined 4 mechanisms that appear to underlie the means by which VDR acts as a tumor suppressor in skin. First, DNA damage repair is curtailed in the absence of the VDR, allowing mutations in DNA to accumulate. Second and third involve the increased activation of the hedgehog and β-catenin pathways in the epidermis in the absence of the VDR, leading to poorly regulated proliferation with reduced differentiation. Finally, VDR deletion leads to a shift in the expression of long noncoding RNAs toward a more oncogenic profile. How these different mechanisms interact and their relative importance in the predisposition of the VDR null epidermis to tumor formation remain under active investigation.

scholarly journals Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice

Immunology ◽  
2006 ◽  
Vol 117 (3) ◽  
pp. 310-318 ◽  
Author(s):  
Monica Froicu ◽  
Yan Zhu ◽  
Margherita T. Cantorna
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Knockout Mice

scholarly journals Dietary Phosphorus Restriction Reverses the Impaired Bone Mineralization in Vitamin D Receptor Knockout Mice

Endocrinology ◽  
2001 ◽  
Vol 142 (1) ◽  
pp. 494-497 ◽  
Author(s):  
Ritsuko Masuyama ◽  
Yumi Nakaya ◽  
Shinya Tanaka ◽  
Hiroshi Tsurukami ◽  
Toshitaka Nakamura ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Knockout Mice ◽  
Bone Mineralization ◽  
Dietary Phosphorus

Frontline Science: Concanavalin A‐induced acute hepatitis is attenuated in vitamin D receptor knockout mice with decreased immune cell function

2019 ◽  
Vol 106 (4) ◽  
pp. 791-801 ◽  
Author(s):  
Naoki Umeda ◽  
Kaori Endo‐Umeda ◽  
Hiroyuki Nakashima ◽  
Shigeaki Kato ◽  
Shuhji Seki ◽  
...  
Keyword(s):  
Vitamin D ◽  
Acute Hepatitis ◽  
Vitamin D Receptor ◽  
Concanavalin A ◽  
Knockout Mice ◽  
Cell Function ◽  
Immune Cell ◽  
Immune Cell Function

Swimming behaviour and post-swimming activity in Vitamin D receptor knockout mice

2006 ◽  
Vol 69 (1) ◽  
pp. 74-78 ◽  
Author(s):  
Thomas H.J. Burne ◽  
Amy N.B. Johnston ◽  
John J. McGrath ◽  
Alan Mackay-Sim
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Knockout Mice ◽  
Swimming Activity ◽  
Swimming Behaviour

scholarly journals 1α, 25-Dihydroxyvitamin D3 and the vitamin D receptor regulates ΔNp63α levels and keratinocyte proliferation

2015 ◽  
Vol 6 (6) ◽  
pp. e1781-e1781 ◽  
Author(s):  
N T Hill ◽  
J Zhang ◽  
M K Leonard ◽  
M Lee ◽  
H N Shamma ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Dihydroxyvitamin D3 ◽  
Keratinocyte Proliferation
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