scholarly journals The Relationship among Circulating Insulin-Like Growth Factor (IGF)-I, IGF-Binding Proteins-1 and -2, and Birth Anthropometry: A Prospective Study

2003 ◽  
Vol 88 (4) ◽  
pp. 1687-1691 ◽  
Author(s):  
Michael S. Boyne ◽  
Minerva Thame ◽  
Franklyn I. Bennett ◽  
Clive Osmond ◽  
John P. Miell ◽  
...  
Keyword(s):  
Growth Factor ◽  
Prospective Study ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Igf Binding Proteins ◽  
Igf I ◽  
Igf Binding ◽  
A Prospective Study ◽  
The Relationship

scholarly journals A Prospective Study on Circulating Insulin-Like Growth Factor I (IGF-I), IGF-Binding Proteins, and Cognitive Function in the Elderly

2000 ◽  
Vol 85 (12) ◽  
pp. 4551-4555 ◽  
Author(s):  
S. Kalmijn ◽  
J. A. M. J. L. Janssen ◽  
H. A. P. Pols ◽  
S. W. J. Lamberts ◽  
M. M. B. Breteler
Keyword(s):  
Cognitive Function ◽  
Growth Factor ◽  
Prospective Study ◽  
Binding Proteins ◽  
The Elderly ◽  
Igf Binding Proteins ◽  
Factor I ◽  
Igf I ◽  
Igf Binding ◽  
A Prospective Study

scholarly journals A prospective study of insulin-like growth factor-I, IGF-binding proteins-1, -2 and -3 and lung cancer risk in women

2001 ◽  
Vol 92 (6) ◽  
pp. 888-892 ◽  
Author(s):  
Annekatrin Lukanova ◽  
Paolo Toniolo ◽  
Arslan Akhmedkhanov ◽  
Carine Biessy ◽  
Nancy J. Haley ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Cancer Risk ◽  
Prospective Study ◽  
Binding Proteins ◽  
Lung Cancer Risk ◽  
Igf Binding Proteins ◽  
Factor I ◽  
Igf Binding ◽  
A Prospective Study

scholarly journals Insulin-like growth factor (IGF)-II binding to IGF-binding proteins and IGF receptors is modified by deletion of the N-terminal hexapeptide or substitution of arginine for glutamate-6 in IGF-II

1993 ◽  
Vol 293 (3) ◽  
pp. 713-719 ◽  
Author(s):  
G L Francis ◽  
S E Aplin ◽  
S J Milner ◽  
K A McNeil ◽  
F J Ballard ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Proteins ◽  
Biological Activities ◽  
Biological Properties ◽  
Hepatoma Cells ◽  
Insulin Like Growth Factor ◽  
Igf Binding Proteins ◽  
Anabolic Response ◽  
Igf I ◽  
Igf Binding

Recombinant insulin-like growth factor-II (IGF-II) and two structural analogues, des(1-6)IGF-II and [Arg6]-IGF-II, were produced to investigate the role of N-terminal residues in binding to IGF-binding proteins (IGFBPs) and hence the biological properties of the modified peptides. The growth factors were modelled on two previously characterized variants of IGF-I, des(1-3)IGF-I and [Arg3]-IGF-I, which both show substantially decreased binding to IGFBPs and were expressed as fusion proteins in Escherichia coli. The biological activities of the corresponding analogues of IGF-I and IGF-II were compared in rat L6 myoblasts and H35B hepatoma cells. In the L6-myoblast protein-synthesis assay, the IGF-II analogues, des(1-6)IGF-II and [Arg6]-IGF-II, were slightly more potent than IGF-II but about 10-fold less potent than IGF-I and 100-fold less potent than the respective IGF-I analogues, des(1-3)IGF-I and [Arg3]IGF-I. In H35 hepatoma cells the anabolic response measured was the inhibition of protein breakdown, and the potency order was insulin >>> [Arg3]-IGF-I > des(1-3)IGF-I > [Arg6]-IGF-II > des(1-6)IGF-II > IGF-I > IGF-II. Binding of the IGFs and their analogues to the type 1 IGF receptor in L6 myoblasts and to the insulin receptor in H35 hepatoma cells did not fully explain the observed anabolic potency differences. Moreover, binding of all four analogues to the IGFBPs secreted by L6 myoblasts and H35B hepatoma cells was greatly decreased compared with the parent IGF. We conclude that the observed anabolic response to each IGF was determined by their relative binding to the competing cell receptor and IGFBP binding sites present.

Ontogenic Changes in the Circulating Concentrations of Insulin-like Growth Factor (IGF)-I, IGF-II, and IGF-Binding Proteins in the Chicken Embryo

1997 ◽  
Vol 106 (2) ◽  
pp. 265-270 ◽  
Author(s):  
Colin G. Scanes ◽  
Robert C. Thommes ◽  
Steven V. Radecki ◽  
Frances C. Buonomo ◽  
James E. Woods
Keyword(s):  
Growth Factor ◽  
Chicken Embryo ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Igf Binding Proteins ◽  
Igf I ◽  
Igf Binding
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