Novel Heat Shock Protein 90 Inhibitor NVP-AUY922 Synergizes With the Histone Deacetylase Inhibitor PXD101 in Induction of Death of Anaplastic Thyroid Carcinoma Cells

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2014-3101 ◽

2015 ◽

Vol 100 (2) ◽

pp. E253-E261 ◽

Author(s):

Si Hyoung Kim ◽

Jun Goo Kang ◽

Chul Sik Kim ◽

Sung-Hee Ihm ◽

Moon Gi Choi ◽

...

Keyword(s):

Heat Shock Protein ◽

Thyroid Carcinoma ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Heat Shock Protein 90 ◽

Anaplastic Thyroid Carcinoma ◽

Carcinoma Cells ◽

Deacetylase Inhibitor

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The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells

Endocrine ◽

10.1007/s12020-015-0706-7 ◽

2015 ◽

Vol 51 (2) ◽

pp. 274-282 ◽

Author(s):

Si Hyoung Kim ◽

Jun Goo Kang ◽

Chul Sik Kim ◽

Sung-Hee Ihm ◽

Moon Gi Choi ◽

...

Keyword(s):

Heat Shock Protein ◽

Thyroid Carcinoma ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitors ◽

Heat Shock Protein 90 ◽

Anaplastic Thyroid Carcinoma ◽

Carcinoma Cells ◽

Synergistic Activity

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MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells

Leukemia Research ◽

10.1016/j.leukres.2008.02.018 ◽

2008 ◽

Vol 32 (9) ◽

pp. 1382-1392 ◽

Author(s):

Chie Nishioka ◽

Takayuki Ikezoe ◽

Jing Yang ◽

Seisho Takeuchi ◽

H. Phillip Koeffler ◽

...

Keyword(s):

Heat Shock Protein ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Heat Shock Protein 90 ◽

Chaperone Function ◽

Deacetylase Inhibitor

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Heat shock protein 90 inhibition results in altered downstream signaling of mutant KIT and exerts synergistic effects on Kasumi-1 cells when combining with histone deacetylase inhibitor

Leukemia Research ◽

10.1016/j.leukres.2011.05.014 ◽

2011 ◽

Vol 35 (9) ◽

pp. 1212-1218 ◽

Author(s):

Wenjuan Yu ◽

Jianxiang Wang ◽

Jie Jin ◽

Wenbin Qian ◽

Jiejing Qian ◽

...

Keyword(s):

Heat Shock Protein ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Synergistic Effects ◽

Heat Shock Protein 90 ◽

Downstream Signaling ◽

Deacetylase Inhibitor

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Phase I Pharmacokinetic and Pharmacodynamic Study of LAQ824, a Hydroxamate Histone Deacetylase Inhibitor with a Heat Shock Protein-90 Inhibitory Profile, in Patients with Advanced Solid Tumors

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-08-0376 ◽

2008 ◽

Vol 14 (20) ◽

pp. 6663-6673 ◽

Author(s):

Johann S. de Bono ◽

Rebecca Kristeleit ◽

Anthony Tolcher ◽

Peter Fong ◽

Simon Pacey ◽

...

Keyword(s):

Heat Shock Protein ◽

Phase I ◽

Solid Tumors ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Heat Shock Protein 90 ◽

Advanced Solid Tumors ◽

Deacetylase Inhibitor ◽

Pharmacodynamic Study

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Hybrid Enzalutamide Derivatives with Histone Deacetylase Inhibitor Activity Decrease Heat Shock Protein 90 and Androgen Receptor Levels and Inhibit Viability in Enzalutamide-Resistant C4-2 Prostate Cancer Cells

Molecular Pharmacology ◽

10.1124/mol.116.103416 ◽

2016 ◽

Vol 90 (3) ◽

pp. 225-237 ◽

Author(s):

Rayna Rosati ◽

Bailing Chen ◽

Mugdha Patki ◽

Thomas McFall ◽

Siyu Ou ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Heat Shock Protein ◽

Histone Deacetylase Inhibitor ◽

Heat Shock Protein 90 ◽

Prostate Cancer Cells ◽

Inhibitor Activity ◽

Deacetylase Inhibitor ◽

Activity Decrease

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A Histone Deacetylase Inhibitor Enhances Killing of Undifferentiated Thyroid Carcinoma Cells by p53 Gene Therapy

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2002-020877 ◽

2002 ◽

Vol 87 (10) ◽

pp. 4821-4824 ◽

Author(s):

Ryo Imanishi ◽

Akira Ohtsuru ◽

Miyoko Iwamatsu ◽

Takashi Iioka ◽

Hiroyuki Namba ◽

...

Keyword(s):

Gene Therapy ◽

Thyroid Carcinoma ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

P53 Gene ◽

Carcinoma Cells ◽

Deacetylase Inhibitor ◽

Undifferentiated Thyroid Carcinoma

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Heat Shock Protein 90 Inhibitors AUY922, BIIB021 and SNX5422 Induce Bim-mediated Death of Thyroid Carcinoma Cells

Anticancer Research ◽

10.21873/anticanres.14634 ◽

2020 ◽

Vol 40 (11) ◽

pp. 6137-6150

Author(s):

SI HYOUNG KIM ◽

YUN KYUNG CHO ◽

JI HYE HUH ◽

JUN GOO KANG ◽

SUNG-HEE IHM ◽

...

Keyword(s):

Heat Shock Protein ◽

Thyroid Carcinoma ◽

Heat Shock Protein 90 ◽

Carcinoma Cells

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Low Concentrations of the Histone Deacetylase Inhibitor, Depsipeptide (FR901228), Increase Expression of the Na+/I- Symporter and Iodine Accumulation in Poorly Differentiated Thyroid Carcinoma Cells

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.86.7.3430 ◽

2001 ◽

Vol 86 (7) ◽

pp. 3430-3435 ◽

Author(s):

M. Kitazono

Keyword(s):

Thyroid Carcinoma ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Differentiated Thyroid Carcinoma ◽

Carcinoma Cells ◽

Poorly Differentiated Thyroid Carcinoma ◽

Low Concentrations ◽

Deacetylase Inhibitor ◽

Poorly Differentiated

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Low Concentrations of the Histone Deacetylase Inhibitor, Depsipeptide (FR901228), Increase Expression of the Na+/I−Symporter and Iodine Accumulation in Poorly Differentiated Thyroid Carcinoma Cells

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.86.7.7621 ◽

2001 ◽

Vol 86 (7) ◽

pp. 3430-3435 ◽

Author(s):

Masaki Kitazono ◽

Rob Robey ◽

Zhirong Zhan ◽

Nicholas J. Sarlis ◽

Monica C. Skarulis ◽

...

Keyword(s):

Thyroid Carcinoma ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Differentiated Thyroid Carcinoma ◽

Carcinoma Cells ◽

Poorly Differentiated Thyroid Carcinoma ◽

Low Concentrations ◽

Deacetylase Inhibitor ◽

Poorly Differentiated

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Gemigliptin, a novel dipeptidyl peptidase-IV inhibitor, exerts a synergistic cytotoxicity with the histone deacetylase inhibitor PXD101 in thyroid carcinoma cells

Journal of Endocrinological Investigation ◽

10.1007/s40618-017-0792-x ◽

2017 ◽

Vol 41 (6) ◽

pp. 677-689 ◽

Author(s):

S. H. Kim ◽

J. G. Kang ◽

C. S. Kim ◽

S.-H. Ihm ◽

M. G. Choi ◽

...

Keyword(s):

Thyroid Carcinoma ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Dipeptidyl Peptidase ◽

Dipeptidyl Peptidase Iv ◽

Carcinoma Cells ◽

Deacetylase Inhibitor ◽

Synergistic Cytotoxicity

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