In vivo somatostatin receptor imaging in medullary thyroid carcinoma

1993 ◽  
Vol 76 (6) ◽  
pp. 1413-1417 ◽  
Author(s):  
D. J. Kwekkeboom
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Somatostatin Receptor ◽  
Receptor Imaging ◽  
Medullary Thyroid ◽  
Somatostatin Receptor Imaging

In vivo somatostatin receptor imaging in medullary thyroid carcinoma.

1993 ◽  
Vol 76 (6) ◽  
pp. 1413-1417
Author(s):  
D J Kwekkeboom ◽  
J C Reubi ◽  
S W Lamberts ◽  
H A Bruining ◽  
A H Mulder ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Somatostatin Receptor ◽  
Receptor Imaging ◽  
Medullary Thyroid ◽  
Somatostatin Receptor Imaging

Somatostatin-Receptor Imaging of Medullary Thyroid Carcinoma

1994 ◽  
Vol 19 (5) ◽  
pp. 416-421 ◽  
Author(s):  
Y KRAUSZ ◽  
S ISH-SHALOM ◽  
R B J DEJONG ◽  
N SHIBLEY ◽  
M LAPIDOT ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Somatostatin Receptor ◽  
Receptor Imaging ◽  
Medullary Thyroid ◽  
Somatostatin Receptor Imaging

Somatostatin receptor imaging in persistent medullary thyroid carcinoma

1995 ◽  
Vol 42 (1) ◽  
pp. 31-37 ◽  
Author(s):  
K. Frank-Raue ◽  
H. Bihl ◽  
U. Dörr ◽  
H. Buhr ◽  
R. Zlegler ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Somatostatin Receptor ◽  
Receptor Imaging ◽  
Medullary Thyroid ◽  
Somatostatin Receptor Imaging

scholarly journals Anti-tumor effects of shikonin derivatives on human medullary thyroid carcinoma cells

2017 ◽  
Vol 6 (2) ◽  
pp. 53-62 ◽  
Author(s):  
Carina Hasenoehrl ◽  
Gert Schwach ◽  
Nassim Ghaffari-Tabrizi-Wizsy ◽  
Robert Fuchs ◽  
Nadine Kretschmer ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Thyroid Carcinoma ◽  
Cell Viability ◽  
Medullary Thyroid Carcinoma ◽  
Petroleum Ether Extract ◽  
Migration And Invasion ◽  
Normal Human Skin ◽  
Medullary Thyroid ◽  
Shikonin Derivatives

New treatment options are needed for medullary thyroid carcinoma (MTC), a highly metastasizing neuroendocrine tumor that is resistant to standard radiotherapy and chemotherapy. We show that the following shikonin derivatives inhibit cell proliferation and cell viability of the MTC cell line TT: acetylshikonin, β,β-dimethylacrylshikonin, shikonin and a petroleum ether extract of the roots of Onosma paniculata containing several shikonin derivatives. The unsubstituted shikonin derivative was found to be the most effective compound with an IC50 of 1.1 µM. The cell viability of normal human skin fibroblasts, however, was not affected by the tested substances, indicating that shikonin derivatives might be selectively toxic for cancer cells. We further report that migration and invasion of TT cells were inhibited at non-toxic concentrations. Finally, shikonin was tested in vivo using the chick chorioallantoic membrane assay, where it significantly reduced tumor growth by inhibiting cell proliferation and inducing apoptosis. In summary, our results suggest that shikonin derivatives have the potential for the treatment of medullary thyroid carcinomas.

Effect of S9788 on the efficiency of doxorubicin in vivo and in vitro in medullary thyroid carcinoma xenograft

1996 ◽  
Vol 7 (3) ◽  
pp. 321-330 ◽  
Author(s):  
C Massart ◽  
J Gibassier ◽  
M Raoul ◽  
A Denais ◽  
S Maugendre ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Medullary Thyroid ◽  
Carcinoma Xenograft

In vivo somatostatin receptor imaging in lung cancer

Lung Cancer ◽  
1991 ◽  
Vol 7 ◽  
pp. 62 ◽  
Author(s):  
G.S. Kho ◽  
E.P. Krenning ◽  
S.W.J. Lamberts ◽  
W.H. Bakker ◽  
H.Y. Oei ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Somatostatin Receptor ◽  
Receptor Imaging ◽  
Somatostatin Receptor Imaging
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