Down-regulation of G alpha s in human myometrium in term and preterm labor: a mechanism for parturition

1994 ◽  
Vol 79 (6) ◽  
pp. 1835-1839 ◽  
Author(s):  
G. N. Europe-Finner
Keyword(s):  
Preterm Labor ◽  
Human Myometrium ◽  
Down Regulation

Down-regulation of G alpha s in human myometrium in term and preterm labor: a mechanism for parturition.

1994 ◽  
Vol 79 (6) ◽  
pp. 1835-1839
Author(s):  
G N Europe-Finner ◽  
S Phaneuf ◽  
A M Tolkovsky ◽  
S P Watson ◽  
A López Bernal
Keyword(s):  
Preterm Labor ◽  
Human Myometrium ◽  
Down Regulation

scholarly journals Preterm Labor is a Distinct Process from Term Labor following Computational Analysis of Human Myometrium.

2021 ◽  
Author(s):  
Jason Phung ◽  
Carol Wang ◽  
Jocelyn Reeders ◽  
Eng-Cheng Chan ◽  
Carlos Riveros ◽  
...  
Keyword(s):  
Preterm Labor ◽  
Computational Analysis ◽  
Human Myometrium ◽  
Distinct Process ◽  
Term Labor

Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

2019 ◽  
Vol 18 ◽  
pp. 96-98 ◽  
Author(s):  
Qingyou Du ◽  
Sofija Jovanović ◽  
Lidija Tulić ◽  
Ivan Tulić ◽  
Aleksandar Jovanović
Keyword(s):  
Human Myometrium ◽  
Pregnancy Induced Hypertension ◽  
Down Regulation ◽  
Induced Hypertension

Down regulation of the angiotensin II receptor subtype AT2 in human myometrium during pregnancy

1994 ◽  
Vol 53 (1) ◽  
pp. 39-45 ◽  
Author(s):  
M. de Gasparo ◽  
S. Whitebread ◽  
M.K. Kalenga ◽  
R. de Hertogh ◽  
P. Crevoisier ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Human Myometrium ◽  
Receptor Subtype ◽  
Angiotensin Ii Receptor ◽  
Down Regulation

scholarly journals Reciprocal Feedback Between miR-181a and E2/ERα in Myometrium Enhances Inflammation Leading to Labor

2016 ◽  
Vol 101 (10) ◽  
pp. 3646-3656 ◽  
Author(s):  
Lu Gao ◽  
Gang Wang ◽  
Wei-Na Liu ◽  
Holly Kinser ◽  
Hector L. Franco ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Cesarean Section ◽  
Pregnant Women ◽  
Preterm Labor ◽  
Elective Cesarean Section ◽  
Human Myometrium ◽  
Myometrial Cells ◽  
Emergency Cesarean ◽  
Tnf Α ◽  
Estradiol 17Β

Context: The initiation of term and preterm labor is associated with an up-regulated inflammatory response in myometrium; however, the underlying signaling pathways remain incompletely defined. Objective: To define the regulatory mechanisms that mediate the increased myometrial inflammatory response leading to labor, we investigated the roles of microRNAs (miRNA/miR). Design and Setting: Human myometrial tissues, isolated smooth muscle cells, and animal models were used to study miR-181a regulation of uterine inflammatory pathways and contractility. Patients: Myometrial tissues from 15 term pregnant women undergoing elective cesarean section (not in labor) and 10 term pregnant women undergoing emergency cesarean section (in labor) were used. Results: Expression of the highly conserved microRNA, miR-181a, was significantly decreased in mouse and human myometrium during late gestation. By contrast, the putative miR-181a targets, TNF-α, and estrogen receptor (ER)-α, and the validated target, c-Fos, key factors in the inflammatory response leading to parturition, were coordinately up-regulated. In studies using human myometrial cells, overexpression of miR-181a mimics repressed basal as well as IL-1β-induced TNF-α, C-C motif chemokine ligand 2 and 8 expression, whereas the expression of the antiinflammatory cytokine, IL-10, was increased. Overexpression of miR-181a dramatically inhibited both spontaneous and IL-1β-induced contraction of human myometrial cells. Notably, miR-181a directly targeted ERα and decreased its expression, whereas estradiol-17β reciprocally inhibited expression of mature miR-181a in myometrial cells. Conclusions: Thus, increased estradiol-17β/ERα signaling in myometrium near term inhibits miR-181a, resulting in a further increase in ERα and proinflammatory signaling. This escalating feedback loop provides novel targets and therapeutic strategies for the prevention of preterm labor and its consequences.

scholarly journals Microarray Analysis of Uterine Gene Expression in Mouse and Human Pregnancy

2003 ◽  
Vol 17 (8) ◽  
pp. 1454-1469 ◽  
Author(s):  
Kathleen E. Bethin ◽  
Yoshihiko Nagai ◽  
Robert Sladek ◽  
Minoru Asada ◽  
Yoel Sadovsky ◽  
...  
Keyword(s):  
Gene Expression ◽  
Preterm Labor ◽  
Human Myometrium ◽  
Oligonucleotide Microarrays ◽  
Mouse Uterus ◽  
Primary Mechanism ◽  
Study Gene Expression ◽  
Induction Of Enzymes ◽  
Labor Patterns ◽  
Term Labor

Abstract Improved care of infants born prematurely has increased their survival. However, the incidence of preterm labor has not changed. To understand the processes involved in preterm labor, we used oligonucleotide microarrays to study gene expression in murine and human uterus during pregnancy. The induction of enzymes for prostaglandin synthesis was used as a marker for important changes during pregnancy because prostaglandins strongly contribute to both human and murine labor. We identified 504 genes that changed at least 2-fold between d 13.5 and 19.0 in the gravid mouse uterus. In the pregnant human myometrium, we found 478 genes that changed at least 2-fold in either term or preterm labor compared with preterm nonlabor specimens and 77 genes that significantly varied in both preterm and term labor. Patterns of gene regulation within functional groups comparing human preterm and term labor were similar, although the magnitude of change often varied. Surprisingly, few genes that changed significantly throughout pregnancy were the same in the mouse and human. These data suggest that functional progesterone withdrawal in human myometrium may not be the primary mechanism for labor induction, may implicate similar mechanisms for idiopathic preterm and term labor in humans, and may identify novel targets for further study.

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