Somatostatin Receptor Subtype Expression in Human Thyroid and Thyroid Carcinoma Cell Lines

1997 ◽  
Vol 82 (6) ◽  
pp. 1857-1862 ◽  
Author(s):  
K. B. Ain
Keyword(s):  
Thyroid Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Somatostatin Receptor ◽  
Human Thyroid ◽  
Receptor Subtype ◽  
Carcinoma Cell Lines ◽  
Thyroid Carcinoma Cell

scholarly journals Retinoic acid-mediated down-regulation of ENO1/MBP-1 gene products caused decreased invasiveness of the follicular thyroid carcinoma cell lines

2008 ◽  
Vol 42 (3) ◽  
pp. 249-260 ◽  
Author(s):  
Bogusz Trojanowicz ◽  
Anja Winkler ◽  
Kathrin Hammje ◽  
Zhouxun Chen ◽  
Carsten Sekulla ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Thyroid Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Follicular Thyroid Carcinoma ◽  
Human Thyroid ◽  
Gene Products ◽  
Down Regulation ◽  
Carcinoma Cell Lines ◽  
Thyroid Carcinoma Cell

Retinoic acid (RA) acts as an anti-proliferative and redifferentiation agent in the therapy of thyroid carcinoma. Our previous studies demonstrated that pretreatment of follicular thyroid carcinoma cell lines FTC-133 and FTC-238 resulted in decreased in vitro proliferation rates and reduced tumor cell growth of xenotransplants. In addition to the previous results, we found that RA led to decreased vitality and invasiveness of FTC-133 and FTC-238 cells as they reacted with reduction of intracellular ATP levels and number of migrated cells respectively. However, the molecular mechanisms by which RA mediates these effects are not well understood. Two-dimensional (2D) screening of the proteins related to ATP metabolism and western blot analysis revealed α-enolase (ENO1) to be down-regulated in FTC-133 and FTC-238 cells after RA treatment. 2D gel detection and mass spectrometric analysis revealed that ENO1 existed as three separate protein spots of distinct pIs (ENO1–A1–A3). Comparative 2D difference gel electrophoresis analysis of fluorescently labeled protein samples of RA-treated and untreated FTC-133 demonstrated a selective down-regulation of ENO1-A1 which we identified as a phosphoprotein. RA caused the dephosphorylation of ENO1-A1. Both, RA-mediated and specific knock-down of ENO1/MBP-1 resulted in the reduction of MYC oncoprotein, and simultaneously decreased proliferation rates of FTC-133 and FTC-238 cell lines. In summary, the RA-mediated down-regulation of the ENO1 gene products and MYC oncoprotein provides a novel molecular mechanism facilitating the anti-proliferative effect of RA in human thyroid carcinoma cells and suggests new pathways for supportive RA therapies.

scholarly journals Expression analysis of facilitative glucose transporters (GLUTs) in human thyroid carcinoma cell lines and primary tumors

2008 ◽  
Vol 291 (1-2) ◽  
pp. 57-62 ◽  
Author(s):  
Raffaele Ciampi ◽  
Agnese Vivaldi ◽  
Cristina Romei ◽  
Alberto Del Guerra ◽  
Piero Salvadori ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Cell Lines ◽  
Expression Analysis ◽  
Carcinoma Cell ◽  
Glucose Transporters ◽  
Human Thyroid ◽  
Primary Tumors ◽  
Carcinoma Cell Lines ◽  
Thyroid Carcinoma Cell

Ape1/Ref-1 expression and cellular localization in human thyroid carcinoma cell lines

2001 ◽  
Vol 24 (3) ◽  
pp. RC10-RC12 ◽  
Author(s):  
D. Russo ◽  
F. Arturi ◽  
S. Bulotta ◽  
L. Pellizzari ◽  
S. Filetti ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Cell Lines ◽  
Cellular Localization ◽  
Carcinoma Cell ◽  
Human Thyroid ◽  
Carcinoma Cell Lines ◽  
Thyroid Carcinoma Cell

scholarly journals Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFκB p65 protein expression

Oncogene ◽  
1997 ◽  
Vol 15 (16) ◽  
pp. 1987-1994 ◽  
Author(s):  
Roberta Visconti ◽  
Janete Cerutti ◽  
Sabrina Battista ◽  
Monica Fedele ◽  
Francesco Trapasso ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Protein Expression ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Human Thyroid ◽  
Neoplastic Phenotype ◽  
Carcinoma Cell Lines ◽  
Thyroid Carcinoma Cell

Inhibitory effects of retinoic acid on invasiveness of human thyroid carcinoma cell lines in vitro

2009 ◽  
Vol 32 (9) ◽  
pp. 731-738 ◽  
Author(s):  
L. Lan ◽  
D. Cui ◽  
Y. Luo ◽  
B. Y. Shi ◽  
L. L. Deng ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Thyroid Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Human Thyroid ◽  
Inhibitory Effects ◽  
Carcinoma Cell Lines ◽  
Thyroid Carcinoma Cell
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