Vitamin D Receptor (VDR) and Parathyroid Hormone Messenger Ribonucleic Acid Levels Correspond to Polymorphic VDR Alleles in Human Parathyroid Tumors

1998 ◽  
Vol 83 (7) ◽  
pp. 2255-2259 ◽  
Author(s):  
T. Carling
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Vitamin D Receptor ◽  
Ribonucleic Acid ◽  
Messenger Ribonucleic Acid ◽  
Parathyroid Tumors

1,25-Dihydroxyvitamin D3 does not up-regulate vitamin D receptor messenger ribonucleic acid levels in hypophosphatemic mice

1992 ◽  
Vol 19 (3) ◽  
pp. 201-213 ◽  
Author(s):  
Shigeo Nakajima ◽  
Kanji Yamaoka ◽  
Shintaro Okada ◽  
J. Wesley Pike ◽  
Yoshiki Seino ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Ribonucleic Acid ◽  
Dihydroxyvitamin D3 ◽  
Messenger Ribonucleic Acid ◽  
1,25 Dihydroxyvitamin D3

scholarly journals The Vitamin D Receptor (VDR) Start Codon Polymorphism in Primary Hyperparathyroidism and Parathyroid VDR Messenger Ribonucleic Acid Levels1

1999 ◽  
Vol 84 (5) ◽  
pp. 1690-1694
Author(s):  
Pamela Correa ◽  
Jonas Rastad ◽  
Peter Schwarz ◽  
Gunnar Westin ◽  
Andreas Kindmark ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Vitamin D Receptor ◽  
Ribonucleic Acid ◽  
Parathyroid Cell ◽  
Mineral Density ◽  
Foki Polymorphism ◽  
Messenger Ribonucleic Acid

Vitamin D regulates parathyroid cell proliferation and secretion of PTH. Increased prevalence of the polymorphic vitamin D receptor (VDR) alleles b, a, and T has been reported in sporadic primary hyperparathyroidism (PHPT), suggesting that these genetic variants may predispose to the disease. Recently, another polymorphism in the VDR gene was related to bone mineral density, and this VDR-FokI polymorphism causes different lengths of the VDR, implying possible functional consequences. The VDR-FokI polymorphism was studied in 182 postmenopausal women with sporadic PHPT and in matched controls. No significant differences in distribution of the VDR-FokI genotypes could be detected between the groups, although there was a tendency toward overrepresentation of the F allele in the PHPT patients (P = 0.05). There were no significant associations with age, serum calcium, serum PTH, bone mineral density, or parathyroid tumor weight. The VDR genotypes were unrelated to VDR and PTH messenger ribonucleic acid levels in the parathyroid adenomas of 42 PHPT patients. In 23 PHPT patients, the Ca2+-PTH set-points were determined in vivo and were unrelated to the VDR alleles. We suggest that the VDR-FokI polymorphism has at most a minor pathogenic importance in the development of PHPT.

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