Parathyroid hormone (PTH)/PTH-related protein receptor messenger ribonucleic acid expression and PTH response in a rat model of secondary hyperparathyroidism associated with vitamin D deficiency.

Endocrinology ◽  
1995 ◽  
Vol 136 (9) ◽  
pp. 3751-3758 ◽  
Author(s):  
G Turner ◽  
C Coureau ◽  
M R Rabin ◽  
B Escoubet ◽  
M Hruby ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Rat Model ◽  
Ribonucleic Acid ◽  
Related Protein ◽  
Messenger Ribonucleic Acid ◽  
Protein Receptor

Relationship of Vitamin D Deficiency and Intraoperative Parathyroid Hormone Elevation in Completion and Total Thyroidectomy

2019 ◽  
Vol 160 (4) ◽  
pp. 612-615 ◽  
Author(s):  
Bradley R. Lawson ◽  
Andrew M. Hinson ◽  
Jacob C. Lucas ◽  
Donald L. Bodenner ◽  
Brendan C. Stack
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Total Thyroidectomy ◽  
Vitamin D Deficiency ◽  
Case Series ◽  
Hormone Levels ◽  
Parathyroid Autotransplantation ◽  
Vitamin D Levels ◽  
Intraoperative Parathyroid Hormone

Objective To quantify how frequently intraoperative parathyroid hormone levels increase during thyroid surgery and to explore a possible relationship between secondary hyperparathyroidism due to vitamin D deficiency and elevation in intraoperative parathyroid hormone. Study Design Case series with chart review. Setting Tertiary academic center. Subjects and Methods A total of 428 consecutive patients undergoing completion and total thyroidectomy by the senior author over a 7-year period were included for analysis. All patients had baseline and postexcision intraoperative parathyroid hormone levels as well as vitamin D levels from the same laboratory. Institute of Medicine criteria were employed for vitamin D stratification (>30, normal; 20-29.9, insufficient; <20, deficient) . Other data analyzed include sex, age, neck dissection status, and parathyroid autotransplantation. Results A total of 118 patients (27.6%) had an intraoperative parathyroid hormone elevation above baseline. Patients with vitamin D deficiency were significantly more likely to experience hormone elevation ( P = .04). When parathyroid hormone rose, it did so by a mean 32.1 pg/mL. Patients with vitamin D deficiency demonstrated significantly larger hormone increases ( P = .03). Conclusion Elevation in intraoperative parathyroid hormone levels above baseline after completion and total thyroidectomy occurs in over one-fourth of cases and is significantly associated with vitamin D deficiency. This study is the first to report this observation. We hypothesize that vitamin D deficiency in these patients may create a subclinical secondary hyperparathyroidism that leads to intraoperative parathyroid hormone elevation when the glands are manipulated. Additional studies will be needed to explore this physiologic mechanism and its clinical significance.

Vitamin D, Parathyroid Hormone, and Acroosteolysis in Systemic Sclerosis

2008 ◽  
Vol 35 (11) ◽  
pp. 2201-2205 ◽  
Author(s):  
YOLANDA BRAUN-MOSCOVICI ◽  
DANIEL E. FURST ◽  
DORON MARKOVITS ◽  
ALEXANDER ROZIN ◽  
PHILIP J. CLEMENTS ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Systemic Sclerosis ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Medical Records ◽  
Disease Duration ◽  
Laboratory Evaluation ◽  
Vitamin D Levels ◽  
Calcium Phosphorus

ObjectiveSclerodactyly with acroosteolysis (AO) and calcinosis are prominent features of systemic sclerosis (SSc), but the pathogenesis of these findings is poorly understood. Vitamin D and parathyroid hormone (PTH) have a crucial role in bone metabolism and resorption and may affect AO and calcinosis. We assessed vitamin D and PTH in patients with SSc.MethodsMedical records of 134 consecutive patients with SSc (American College of Rheumatology criteria) followed at the rheumatology department during the years 2003–2006 were reviewed for clinical assessment, laboratory evaluation [including 25(OH) vitamin D, calcium, phosphorus, alkaline phosphatase, PTH, creatinine, and albumin]; imaging data confirming AO and/or calcinosis. Patients followed routinely at least once a year were included (81 patients). Of these, 60 patients’ medical records were found to have complete, relevant clinical, laboratory, and radiographic imaging.ResultsThirteen patients had diffuse disease and 47 limited disease — 51 women and 9 men, 44 Jews and 16 Arabs; mean age 55 ± 14 years; disease duration 8 ± 6 years. AO with or without calcinosis was observed in 42 patients (70%). Vitamin D deficiency was found in 46% of patients (16 out of 44 Jewish patients, 10 out of 16 Arab patients). PTH was elevated in 21.7% of patients. Significant correlations were observed between acroosteolysis and PTH (p = 0.015), calcinosis (p = 0.009), and disease duration (p = 0.008), and between PTH and vitamin D levels (p = 0.01). All patients had normal serum concentrations of calcium, phosphorus, magnesium, and albumin, and liver and kidney functions.ConclusionIn this group of Mediterranean patients with SSc, the incidence of vitamin D deficiency and secondary hyperparathyroidism was surprisingly high. This finding correlated with the occurrence of AO and calcinosis. Low levels of vitamin D may reflect silent malabsorption and might be a risk factor for secondary hyperparathyroidism and bone resorption. Traditional dress habits and low exposure to sun may contribute to vitamin D deficiency in an Arab population but do not explain all the findings. The pathogenesis of these findings needs to be corroborated in other SSc populations.

scholarly journals Bone Status in Patients with Sickle Cell Disease:

2011 ◽  
Vol 1 (2) ◽  
pp. 25-31
Author(s):  
Bassem S. El Deek
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Sickle Cell Disease ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Sickle Cell ◽  
Common Finding ◽  
Cell Disease ◽  
Laboratory Investigations ◽  
The Mean

Objectives (background): Both sickle cell disease and vitamin D deficiency are common among Saudi population. The present work asses Parathyroid hormone/Vitamin D axis as well as bone dynamics in young Saudi adults with sickle cell disease. Methods: A case-control study includes forty patients known to have sickle cell disease from the outpatient clinics of North Western Armed Forces Hospital, Tabuk were randomly selected for the study. Another 120 healthy individuals were involved as control. Cases and control were subjected to full history taking, clinical examination, and radiologic and laboratory investigations. Results: Bone image revealed diffuse osteopenia in 16 (40%) of the cases, avascular necrosis of the femoral head in 6 (15%), code fish vertebral bodies in 6 (15%) and coarse trabecular pattern in 6 (15%). Laboratory investigations for patients revealed hypocalcemia in 18 (45%), secondary hyperparathyroidism in 24 (60%), non-detectable vitamin D in 30 (75%) and detectable but subnormal vitamin D in 10 (25%). The mean level for serum calcium in cases was significantly less than that for the control (p < 0.001). The mean level for serum intact parathyroid hormone was significantly higher in the patients than the control (p < 0.001). The mean serum level for the Serum 25-hydroxyvitamin was significantly lower in the studied cases than the control. For the serum bone, specific alkaline phosphatase the mean level was significantly higher in case than control (p < 0.001). Conclusion: Vitamin D deficiency through a common finding it is more severe in patients with sickle cell disease with subsequent secondary hyperparathyroidism and frequent hypocalcemia.

scholarly journals Bone Status in Patients with Sickle Cell Disease:

2011 ◽  
Vol 1 (2) ◽  
pp. 25-31
Author(s):  
Bassem S. El Deek
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Sickle Cell Disease ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Sickle Cell ◽  
Common Finding ◽  
Cell Disease ◽  
Laboratory Investigations ◽  
The Mean

Objectives (background): Both sickle cell disease and vitamin D deficiency are common among Saudi population. The present work asses Parathyroid hormone/Vitamin D axis as well as bone dynamics in young Saudi adults with sickle cell disease. Methods: A case-control study includes forty patients known to have sickle cell disease from the outpatient clinics of North Western Armed Forces Hospital, Tabuk were randomly selected for the study. Another 120 healthy individuals were involved as control. Cases and control were subjected to full history taking, clinical examination, and radiologic and laboratory investigations. Results: Bone image revealed diffuse osteopenia in 16 (40%) of the cases, avascular necrosis of the femoral head in 6 (15%), code fish vertebral bodies in 6 (15%) and coarse trabecular pattern in 6 (15%). Laboratory investigations for patients revealed hypocalcemia in 18 (45%), secondary hyperparathyroidism in 24 (60%), non-detectable vitamin D in 30 (75%) and detectable but subnormal vitamin D in 10 (25%). The mean level for serum calcium in cases was significantly less than that for the control (p < 0.001). The mean level for serum intact parathyroid hormone was significantly higher in the patients than the control (p < 0.001). The mean serum level for the Serum 25-hydroxyvitamin was significantly lower in the studied cases than the control. For the serum bone, specific alkaline phosphatase the mean level was significantly higher in case than control (p < 0.001). Conclusion: Vitamin D deficiency through a common finding it is more severe in patients with sickle cell disease with subsequent secondary hyperparathyroidism and frequent hypocalcemia.

Reversible Resistance to the Renal Action of Parathyroid Hormone in Human Vitamin D Deficiency

1982 ◽  
Vol 62 (4) ◽  
pp. 381-387 ◽  
Author(s):  
I. G. Lewin ◽  
S. E. Papapoulos ◽  
G. N. Hendy ◽  
S. Tomlinson ◽  
J. L. H. O'riordan
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Cyclic Amp ◽  
Urinary Excretion ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Normal Subjects ◽  
Cyclic Monophosphate ◽  
Renal Action ◽  
Plasma Adenosine

1. The response to exogenous parathyroid hormone (PTH) was tested in normal subjects and patients with osteomalacia due to vitamin D deficiency; 200 MRC units of bovine PTH were administered intravenously. 2. The rise in plasma adenosine 3′:5′-cyclic monophosphate (cyclic AMP) and the increase in urinary excretion of cyclic AMP were reduced in the patients with vitamin D deficiency. After treatment with vitamin D the responses returned to normal. 3. It is suggested that this reversible resistance is due to the secondary hyperparathyroidism associated with vitamin D deficiency.

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