Parathyroid Hormone-Related Protein-(1-36) Stimulates Renal Tubular Calcium Reabsorption in Normal Human Volunteers: Implications for the Pathogenesis of Humoral Hypercalcemia of Malignancy

2001 ◽  
Vol 86 (4) ◽  
pp. 1525-1531 ◽  
Author(s):  
M. A. Syed
Keyword(s):  
Parathyroid Hormone ◽  
Related Protein ◽  
Humoral Hypercalcemia Of Malignancy ◽  
Humoral Hypercalcemia ◽  
Parathyroid Hormone Related Protein ◽  
Human Volunteers ◽  
Calcium Reabsorption ◽  
Normal Human ◽  
Renal Tubular ◽  
Tubular Calcium Reabsorption

Elevated parathyroid hormone-related protein and hypercalcemia in two dogs with schistosomiasis

2001 ◽  
Vol 37 (4) ◽  
pp. 349-355 ◽  
Author(s):  
JM Fradkin ◽  
AM Braniecki ◽  
TM Craig ◽  
F Ramiro-Ibanez ◽  
KS Rogers ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Granulomatous Inflammation ◽  
Clinical Findings ◽  
Diagnostic Evaluation ◽  
Related Protein ◽  
Humoral Hypercalcemia Of Malignancy ◽  
Fecal Examination ◽  
Humoral Hypercalcemia ◽  
Parathyroid Hormone Related Protein ◽  
Clinicopathological Findings

Two adult dogs were evaluated for hypercalcemia. Diagnostic evaluation identified elevated parathyroid hormone-related protein (PTHrP) and presumptive humoral hypercalcemia of malignancy. At necropsy, schistosomiasis was diagnosed. North American schistosomiasis is caused by Heterobilharzia americana. Clinical findings may include dermatitis, coughing, diarrhea, and anorexia. Clinicopathological findings may include hypercalcemia, hyperglobulinemia, hypoalbuminemia, anemia, and eosinophilia. Diagnosis by fecal examination is difficult. Praziquantel or fenbendazole treatment may be curative or palliative. These are the first reported cases of hypercalcemia with elevated PTHrP in animals without diagnosed malignancy. Elevation of PTHrP has not been previously reported in hypercalcemic humans or in animals with granulomatous inflammation.

Defining the roles of parathyroid hormone-related protein in normal physiology

1996 ◽  
Vol 76 (1) ◽  
pp. 127-173 ◽  
Author(s):  
W. M. Philbrick ◽  
J. J. Wysolmerski ◽  
S. Galbraith ◽  
E. Holt ◽  
J. J. Orloff ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Fetal Life ◽  
Related Protein ◽  
Humoral Hypercalcemia Of Malignancy ◽  
Physiological Functions ◽  
Hypercalcemia Of Malignancy ◽  
Normal Tissues ◽  
Humoral Hypercalcemia ◽  
Parathyroid Hormone Related Protein ◽  
Differentiation And Proliferation

Parathyroid hormone-related protein (PTHrP) was discovered as a result of a search for the circulating factor secreted by cancers which causes the common paraneoplastic syndrome humoral hypercalcemia of malignancy. Since the identification of the peptide in 1982 and the cloning of the cDNA in 1987, it has become clear that PTHrP is a prohormone that is posttranslationally cleaved by prohormone convertases to yield a complex family of peptides, each of which is believed to have its own receptor. It is also clear that the PTHrP gene is expressed not only in cancers but also in the vast majority of normal tissues during adult and/or fetal life. In contrast to the situation in humoral hypercalcemia of malignancy in which PTHrP plays the role of a classical "endocrine" hormone, under normal circumstances PTHrP plays predominantly paracrine and/or autocrine roles. These apparent physiological functions are also complex and appear to include 1) regulation of smooth muscle (vascular, intestinal, uterine, bladder) tone, 2) regulation of transepithelial (renal, placental, oviduct, mammary gland) calcium transport, and 3) regulation of tissue and organ development, differentiation, and proliferation. In this review, the discovery of PTHrP, the structure of its gene and its cDNAs, and the posttranslational processing of the initial translation products are briefly reviewed. Attention is then focused on a detailed organ system-oriented review of the normal physiological functions of PTHrP.

A Parathyroid Hormone–Related Protein–Secreting Metastatic Epithelioid Leiomyosarcoma

2003 ◽  
Vol 127 (4) ◽  
pp. e181-e185
Author(s):  
Shou-jiang Tang ◽  
Sunil Geevarghese ◽  
Sammy Saab ◽  
Dorothy Martinez ◽  
Andre Van Herle ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Tumor Resection ◽  
Smooth Muscle Tumor ◽  
Uterine Leiomyosarcoma ◽  
Related Protein ◽  
Humoral Hypercalcemia Of Malignancy ◽  
Uterine Tumor ◽  
Humoral Hypercalcemia ◽  
Parathyroid Hormone Related Protein ◽  
Calcium Phosphorus

Abstract A diagnosis of parathyroid hormone–related protein (PTH-rP)–secreting metastatic uterine epithelioid leiomyosarcoma was made in a 61-year-old woman with humoral hypercalcemia of malignancy. A primary uterine tumor had been removed 10 years previously, which had been associated with a short history of hypercalcemia. The original uterine tumor was diagnosed as a smooth muscle tumor of uncertain malignant potential. To the best of our knowledge, this is the first reported case of a PTH-rP–secreting uterine leiomyosarcoma. We demonstrate the dramatic changes in serum calcium, phosphorus, PTH, and PTH-rP levels after tumor resection. Extensive biochemical analysis and detailed immunohistochemical and ultrastructural characterization demonstrate several features of this tumor.

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