Collaborative Study of the Effects of Human Growth Hormone in Growth Hormone Deficiency. II. Development and Significance of Antibodies to Human Growth Hormone During the First Year of Therapy

1974 ◽  
Vol 38 (1) ◽  
pp. 14-18 ◽  
Author(s):  
S. DOUGLAS FRASIER ◽  
THOMAS ACETO ◽  
ALVIN B. HAYLES ◽  
MARY L. PARKER ◽  
HEINO F. L. MEYER-BAHLBURG
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Human Growth Hormone ◽  
Collaborative Study ◽  
Human Growth ◽  
Hormone Deficiency ◽  
First Year

Collaborative Study of the Effects of Human Growth Hormone in Growth Hormone Deficiency. I. First Year of Therapy

1972 ◽  
Vol 35 (4) ◽  
pp. 483-496 ◽  
Author(s):  
THOMAS ACETO ◽  
S. DOUGLAS FRASIER ◽  
ALVIN B. HAYLES ◽  
HEINO F. L. MEYER-BAHLBURG ◽  
MARY L. PARKER ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Human Growth Hormone ◽  
Collaborative Study ◽  
Human Growth ◽  
Hormone Deficiency ◽  
First Year

Prospective clinical trial of human growth hormone in short children without growth hormone deficiency

1984 ◽  
Vol 104 (2) ◽  
pp. 172-176 ◽  
Author(s):  
J.M. Gertner ◽  
M. Genel ◽  
S.P. Gianfredi ◽  
R.L. Hintz ◽  
R.G. Rosenfeld ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Prospective Clinical Trial ◽  
Hormone Deficiency ◽  
Short Children

Isolated human growth hormone deficiency. III. Insulin secretion in sexual ateliotic dwarfism

Metabolism ◽  
1968 ◽  
Vol 17 (11) ◽  
pp. 1005-1011 ◽  
Author(s):  
T.J. Merimee ◽  
D. Rabinowitz ◽  
D.L. Rimoin ◽  
V.A. McKusick
Keyword(s):  
Growth Hormone ◽  
Insulin Secretion ◽  
Growth Hormone Deficiency ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Hormone Deficiency

Low Dose Single Weekly Injections of Growth Hormone: Response during First Year of Therapy of Hypopituitarism

PEDIATRICS ◽  
1980 ◽  
Vol 66 (2) ◽  
pp. 272-276
Author(s):  
Arlan L. Rosenbloom ◽  
William J. Riley ◽  
Janet H. Silverstein ◽  
Adolfo D. Garnica ◽  
Michael L. Netzloff ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Standard Dose ◽  
Collaborative Study ◽  
Human Growth ◽  
Hormone Deficiency ◽  
First Year ◽  
Growth Responses ◽  
The Us ◽  
Study Experience ◽  
British Experience

Initial year growth responses to single weekly injections of 2.5 units human growth hormone (hGH) in 29 patients with hypopituitarism (130 units/yr/patient) were compared to responses in a series using smaller doses in conjunction with androgen (48 to 112 units/yr); the US collaborative study experience with the standard dose (2 units 3 times/wk = 312 units/yr), and with two size-adjusted doses (0.06 units/kg 3 times/wk = 212 ± 94 SD units/yr, 0.03 units/kg 3 times/wk = 116 ± 33 units/yr); and to the British experience with much larger doses (1,040 units/yr). During the first year of hGH treatment our patients grew an average 13% faster than the androgen-supplemented and collaborative study-0.03 units/kg/dose groups. They had a similar pace to the collaborative study-312 units/yr and 0.06 units/kg/dose patients, but grew 15% more slowly than did the British patients. Growth response correlated positively with age and negatively with hGH dose per kilogram of body weight. Of 17 patients with isolated growth hormone deficiency ten developed hypothyroidism with hGH therapy, leading to a policy of routine adjunctive thyroxine replacement.

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