Morphine Withdrawal-induced Diarrhoea and Acetic Acid-induced Abdominal Constriction: Animal Models for the Evaluation of 5-HT3 Ligands in the Treatment of Irritable Bowel Syndrome

2000 ◽  
Vol 6 (11) ◽  
pp. 513-516
Author(s):  
A. Veeranjaneyulu ◽  
N. Sridhar ◽  
r.j. babu ◽  
c.n.v.h.b. Gupta ◽  
R. Malavika ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Acetic Acid ◽  
Animal Models ◽  
Morphine Withdrawal ◽  
Irritable Bowel ◽  
Abdominal Constriction

scholarly journals FODMAP Fingerprinting of Bakery Products and Sourdoughs: Quantitative Assessment and Content Reduction through Fermentation

Foods ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 894
Author(s):  
Johannes Pitsch ◽  
Georg Sandner ◽  
Jakob Huemer ◽  
Maximilian Huemer ◽  
Stefan Huemer ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Acetic Acid ◽  
Lactic Acid ◽  
Low Temperature ◽  
Quantitative Assessment ◽  
Bakery Products ◽  
Fermentation Products ◽  
Fermentation Temperature ◽  
Digestive Disorders ◽  
Irritable Bowel

Fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) are associated with digestive disorders and with diseases such as irritable bowel syndrome. In this study, we determined the FODMAP contents of bread, bakery products, and flour and assessed the effectiveness of sourdough fermentation for FODMAP reduction. The fermentation products were analyzed to determine the DP 2–7 and DP >7 fructooligosaccharide (FOS) content of rye and wheat sourdoughs. FOSs were reduced by Acetobacter cerevisiae, Acetobacter okinawensis, Fructilactobacillus sanfranciscensis, and Leuconostoc citreum to levels below those in rye (−81%; −97%) and wheat (−90%; −76%) flours. The fermentation temperature influenced the sourdough acetic acid to lactic acid ratios (4:1 at 4 °C; 1:1 at 10 °C). The rye sourdough contained high levels of beneficial arabinose (28.92 g/kg) and mannitol (20.82 g/kg). Our study contributes in-depth knowledge of low-temperature sourdough fermentation in terms of effective FODMAP reduction and concurrent production of desirable fermentation byproducts.

scholarly journals Stress-Induced Visceral Pain: Toward Animal Models of Irritable-Bowel Syndrome and Associated Comorbidities

2015 ◽  
Vol 6 ◽  
Author(s):  
Rachel D. Moloney ◽  
Siobhain M. O’Mahony ◽  
Timothy G. Dinan ◽  
John F. Cryan
Keyword(s):  
Irritable Bowel Syndrome ◽  
Animal Models ◽  
Visceral Pain ◽  
Irritable Bowel

Systematic review of animal models of post-infectious/post-inflammatory irritable bowel syndrome

2010 ◽  
Vol 46 (2) ◽  
pp. 164-174 ◽  
Author(s):  
Hong-Yan Qin ◽  
Justin C. Y. Wu ◽  
Xu-Dong Tong ◽  
Joseph J. Y. Sung ◽  
Hong-Xi Xu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Animal Models ◽  
Irritable Bowel ◽  
Post Infectious

scholarly journals Involvement of thermo-sensitive TRPM8 channels in visceral hypersensitivity in irritable bowel syndrome animal models

2020 ◽  
Vol 93 (0) ◽  
pp. 1-SS-26
Author(s):  
Hirohide Muramatsu ◽  
Yoshiki Nishimura ◽  
Yurika Arase ◽  
Wakana Uematsu ◽  
Takumi Yamakawa ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Animal Models ◽  
Visceral Hypersensitivity ◽  
Irritable Bowel

The Urinary 5-Hydroxyindole Acetic Acid and Plasma Nitric Oxide Levels in Irritable Bowel Syndrome: A Preliminary Study

2005 ◽  
Vol 50 (1) ◽  
pp. 27-29 ◽  
Author(s):  
A Yazar ◽  
K Büyükafpar ◽  
G Polat ◽  
C Pata ◽  
A Kanýk ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Irritable Bowel Syndrome ◽  
Acetic Acid ◽  
Venous Blood ◽  
Group 3 ◽  
Preliminary Study ◽  
The Difference ◽  
Group 2 ◽  
Irritable Bowel ◽  
Group 1

Background and Aims: Postprandial increase of 3-hydroxytryptamine (5-HT) has been implicated in irritable bowel syndrome (IBS). There is evidence that nitric oxide (NO) may act as a mediator of 5-HT-evoked secretions in the colon. Our aim is to investigate the role of urinary 5-hydroxyindole acetic acid (5-HIAA) and plasma NO levels (with diarrhoea) in IBS patients. Methods: Nineteen (with constipation) IBS patients (group 1), 22 IBS patients (group 2) and 18 healthy controls (group 3) were included in the study. The diagnosis of IBS was made according to the Rome I Criteria. The urine was collected for determination of 5-HIAA and venous blood was collected from each subject for the measurement of plasma NO levels. Results: The levels of urinary 5-HIAA mmol/day and plasma NO mmol/l of group 1 (22,4±2,2 and 29,4±2 respectively) were significantly higher than group 3(14,2 ± 2,3 and 21,3 ± 2,1 respectively) (p =0,036 and p =0,019 respectively). The NO level of group 1 was also significantly higher than group 2(21,8 ± 1,9) (p = 0,021). The 5-HIAA level of group 1 was higher than group 2 (15,2, ± 2,1) and the difference was marginally significant (p = 0,055). There was no difference between group 2 and group 3 with respect to 5-HIAA and NO levels. Conclusions: The results of this preliminary study lend support to the involvement of 5-HT in some symptomatology of diarrhoea predominant IBS. Furthermore, NO may be one of the effector mediators of the 5-HT-induced symptoms in these patients.

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