Localization of the Serotonin Transporter in the Dog Intestine and Comparison to the Rat and Human Intestines

Serotonin is crucial in gastrointestinal functions, including motility, sensitivity, secretion, and the inflammatory response. The serotonin transporter (SERT), responsible for serotonin reuptake and signaling termination, plays a prominent role in gastrointestinal physiology, representing a promising therapeutic target in digestive disorders. Serotonin transporter expression has been poorly investigated in veterinary medicine, under both healthy and pathological conditions, including canine chronic enteropathy, in which the serotonin metabolism seems to be altered. The aim of the present study was to determine the distribution of SERT immunoreactivity (SERT-IR) in the dog intestine and to compare the findings with those obtained in the rat and human intestines. Serotonin transporter-IR was observed in canine enterocytes, enteric neurons, lamina propria cells and the tunica muscularis. Data obtained in dogs were consistent with those obtained in rats and humans. Since the majority of the serotonin produced by the body is synthesized in the gastrointestinal tract, SERT-expressing cells may exert a role in the mechanism of serotonin reuptake.

DIGESTIVE DISORDERS (ANNAVAHA SROTAS VYADHI) IN OLD AGE – ISSUES AND POSSIBLE SOLUTIONS

Old age is the result of the natural process of ageing and the time to enjoy life. As at this time, we are almost free from all responsibilities. But it can be enjoyed only when one is free from major ailments otherwise it becomes a great burden on ourselves as well as on others too. Due to increased health awareness, the average age of people is increasing day by day and the advancement in medical science provides great help in this regard. Therefore, peo- ple live longer but the natural process of ageing and exposure to unfavourable things causes a lot of derangements and weakening of bodily systems and organs in old age. So, there is a great need for geriatric health care in day- to-day practice so that we can improve the quality of life of old age. Besides a lot of major health problems of old age like Heart Disease, Hypertension, Diabetics, Joint disorders, Dementia, Strokes, etc; some minor ailments are equally important as they are often the cause of many major ailments e.g., Gastric Upsets, Insomnia, Anxiety, etc. Keywords: Digestive Disorders, Old age, Vriddhaavastha, Annavahasrotasvyadhi, Issues, Solutions, Agni

Prof. L. Langstein. Infant dystrophies and diarrhea. Reprinted under the editorship of Dr. I. Ya. Serebriyskiy with a foreword by prof. G.N.Speransky. GMI. 1929 344 pp. 3 r. 75 k.

The main feature of the book is the simplicity of the presentation of the subject; the author is an opponent of the complex nomenclature and confusing divisions adopted in the literature on digestive disorders in infants and making it difficult for the practitioner to familiarize himself with this department of pediatrics. In each of the two sections of the book ("dystrophies" and "diarrhea"), the etiological factors leading to the named diseases are discussed in detail, their prognosis depending on different circumstances and dietotherapy is analyzed in great detail, and the author uses only simple nutritional mixtures that are easy to make in any setting.

Some improvements in the technique of creating an "artificial stomach" from the small intestine in partial and total resections of the stomach

The literature of recent decades about the long-term consequences of partial and total resections of the stomach clearly indicates that a significant part of patients after these operations have persistent digestive disorders. The developing peculiar complex symptom complex is designated by various names: "agastral asthenia" (A. A. Busalov, M. S. Govorova), "resection disease" (G. G. Karavanov and O. V. Filts), "hyperglycemic syndrome" (OL Gordon), "hypoglycemic syndrome"; in foreign literature, the term "dumping syndrome" or "postgastrectomy syndrome" is often used.

Correlation and Path Analysis Studies in Turmeric (Curcuma longa)

Turmeric (Curcuma longa), a flowering plant in the ginger family, is widely used as a food coloring in curry powder. Turmeric has long been used in both Ayurvedic and Chinese medicine an anti-inflammatory, to treat digestive disorders and liver problems. The active ingredient in turmeric is curcumin, which have been the various medicinal properties. To extract the curcumin, best variety should be selected. The ultimate aim of any programme is to obtain the high yield with quality and studies like correlation and path coefficient analysis to understand the association different characters and their final effect on the yield. The present study was attempted in this direction to analyze the association of different character on yield in Turmeric.

Digestive disorders induced by the accumulation of arsenic in the human body

Exposure to arsenic is common, but unconscious, inducing major imbalances especially in the digestive tract, lungs, skin. Contamination is achieved by exposure to arsenic in the air, soil, groundwater, food. It is noted the use of arsenic in pesticides, herbicides, paints, wood preservatives, drinking water, various foods with a wide range of consumption (seafood, rice – including rice milk, rice bran, rice cereals, rice syrup rice, rice crackers). The diagnosis of arsenic poisoning is an important step in establishing the diet and detoxification treatment, focusing on the cause, not the symptoms. We present the case of a 45-year-old patient with symptoms manifested in the digestive tract for 4 years: abdominal bloating, cramps, vomiting, weekly episodes of acute diarrhea. During these period the patient received multiple treatments depending on the symptoms, without a significant improvement, without performing specific investigations of arsenic poisoning. The personalized diet and treatment plan, used in the case of this patient, for a period of 4 months was distinguished by a total solution of the manifestations presented in the anamnesis stage.