Neonatal status epilepticus vs recurrent neonatal seizures: Clinical findings and outcome

Midazolam is a short-acting water soluble benzodiazepine that has been used with an increasing frequency in the last years. Although there are reports on its use in status epilepticus, there is none in the neonatal period. A pre-term (35 w) AGA newborn infant with a severe hypoxic-ischemic encephalopathy secondary to grade ED hyaline membrane disease developed status epilepticus in the first 6 hours of life and was successfully treated with midazolam after phenobarbital and phenytoin failed to achieve seizure control. Dosage schedule was 0.2 mg/kg IV, followed by continuous infusion of 0.025 mg/kg/h. Midazolam is an effective drug for neonatal status epilepticus and more experience should accumulate before it can be routinely employed in the neonatal period. This case shows that it is a possible option before using more dangerous drugs, such as thionembutal.

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Neonatal Seizures and Status Epilepticus

Journal of Clinical Neurophysiology ◽

10.1097/wnp.0b013e31826bd90d ◽

2012 ◽

Vol 29 (5) ◽

pp. 441-448 ◽

Cited By ~ 45

Author(s):

Nicholas S. Abend ◽

Courtney J. Wusthoff

Keyword(s):

Status Epilepticus ◽

Neonatal Seizures

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Neonatal Seizures and Status Epilepticus

Handbook of ICU EEG Monitoring ◽

10.1891/9780826168627.0023 ◽

2018 ◽

Author(s):

Rawad Obeid ◽

Tammy N. Tsuchida

Keyword(s):

Status Epilepticus ◽

Neonatal Seizures

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Status epilepticus as presenting manifestation of H1N1 infection

International Journal of Epilepsy ◽

10.1016/j.ijep.2014.06.002 ◽

2015 ◽

Vol 02 (02) ◽

pp. 084-086 ◽

Cited By ~ 1

Author(s):

Aastha Takkar ◽

Manoj Goyal ◽

Manish Modi ◽

Parampreet Kharbanda ◽

Lakshminarayana Yaddanapudi ◽

...

Keyword(s):

Status Epilepticus ◽

Antiviral Treatment ◽

Neurological Complications ◽

Clinical Findings ◽

Convulsive Status Epilepticus ◽

H1n1 Pandemic ◽

H1n1 Infection ◽

Serological Tests ◽

History Of

Abstract Background During the global H1N1 pandemic, neurological complications were reported in approximately 6–10% of children suffering from H1N1 infection, but only rarely in adults. Generalized convulsive status epilepticus (GCSE) as a presenting manifestation of H1N1 infection in an adult is exceedingly rare and has not been reported in literature. We report a patient who presented to us with GCSE as a presenting manifestation of H1N1 infection who improved following appropriate antiviral treatment. Methods and results This 20-year-old gentleman presented to us with history of fever followed by GCSE of 24 h duration. He was treated symptomatically and was evaluated in detail. He was diagnosed to be suffering from H1N1 infection based on appropriate serological tests. After start of antiviral therapy, he improved and is doing well at 4 months follow up. Conclusion This case report further expands the spectrum of clinical findings associated with sporadic H1N1 infection. A possibility of H1N1 infection should be considered in all patients who present with GCSE without any obvious cause so that appropriate diagnostic tests and treatment can be carried out at the earliest.

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Benign neonatal sleep myoclonus in a child

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20194752 ◽

2019 ◽

Vol 6 (6) ◽

pp. 2678

Author(s):

Imella Marcos ◽

Darto Saharso ◽

Prastiya Indra Gunawan

Keyword(s):

Differential Diagnosis ◽

Status Epilepticus ◽

Clinical Manifestation ◽

First Year ◽

History Taking ◽

Neonatal Seizures ◽

Newborn Period ◽

Abnormal Movements ◽

Neurologic Impairment ◽

First Year Of Life

Benign neonatal sleep myoclonus (BNSM), is a disorder generally mistaken for seizures during the newborn period. Benign neonatal sleep myoclonus is featured by myoclonic "lightninglike" jerks of the extremities that exclusively occur during sleep; it is not associated with epilepsy that occur only during sleep and cease abruptly when the child is agitated. This case reported was a 50 days-old baby boy with a history suggestive of abnormal movements for limbs noted over the preceding 7 days. Diagnosis of BNSM in infant based on history taking, clinical manifestation, and with no electroencephalographic changes. BNSM is usually not associated with any other neurologic impairment and spontaneously subsides within the first year of life. Its importance lies in the differential diagnosis with the epileptic, especially myoclonic, seizures of infancy. BNSM can be misinterpreting for neonatal seizures or even neonatal status epilepticus, the recognition of benign sleep myoclonus of infancy is imperative to elude unnecessary diagnostic studies and treatments.

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