scholarly journals Decreased occipital lobe metabolism by FDG-PET/CT

2017 ◽  
Vol 5 (1) ◽  
pp. e413 ◽  
Author(s):  
John C. Probasco ◽  
Lilja Solnes ◽  
Abhinav Nalluri ◽  
Jesse Cohen ◽  
Krystyna M. Jones ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Fdg Pet ◽  
Medical Center ◽  
Academic Medical Center ◽  
Autoimmune Encephalitis ◽  
Occipital Lobe ◽  
Nmda Receptor Encephalitis ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Occipital Lobes

Objective:To compare brain metabolism patterns on fluorodeoxyglucose (FDG)-PET/CT in anti–NMDA receptor and other definite autoimmune encephalitis (AE) and to assess how these patterns differ between anti–NMDA receptor neurologic disability groups.Methods:Retrospective review of clinical data and initial dedicated brain FDG-PET/CT studies for neurology inpatients with definite AE, per published consensus criteria, treated at a single academic medical center over a 10-year period. Z-score maps of FDG-PET/CT were made using 3-dimensional stereotactic surface projections in comparison to age group–matched controls. Brain region mean Z scores with magnitudes ≥2.00 were interpreted as significant. Comparisons were made between anti–NMDA receptor and other definite AE patients as well as among patients with anti–NMDA receptor based on modified Rankin Scale (mRS) scores at the time of FDG-PET/CT.Results:The medial occipital lobes were markedly hypometabolic in 6 of 8 patients with anti–NMDA receptor encephalitis and as a group (Z = −4.02, interquartile range [IQR] 2.14) relative to those with definite AE (Z = −2.32, 1.46; p = 0.004). Among patients with anti–NMDA receptor encephalitis, the lateral and medial occipital lobes were markedly hypometabolic for patients with mRS 4–5 (lateral occipital lobe Z = −3.69, IQR 1; medial occipital lobe Z = −4.08, 1) compared with those with mRS 0–3 (lateral occipital lobe Z = −0.83, 2; p < 0.0005; medial occipital lobe Z = −1.07, 2; p = 0.001).Conclusions:Marked medial occipital lobe hypometabolism by dedicated brain FDG-PET/CT may serve as an early biomarker for discriminating anti–NMDA receptor encephalitis from other AE. Resolution of lateral and medial occipital hypometabolism may correlate with improved neurologic status in anti–NMDA receptor encephalitis.

Changes in cerebral metabolism detected by 18F-FDG PET-CT in a case of anti-NMDA receptor encephalitis

2012 ◽  
Vol 31 (4) ◽  
pp. 219-222
Author(s):  
M.A. Ochoa-Figueroa ◽  
C. Cárdenas-Negro ◽  
A. Allende-Riera ◽  
J. Uña-Gorospe ◽  
D. Cabello García ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Fdg Pet ◽  
Cerebral Metabolism ◽  
Nmda Receptor Encephalitis ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

18F-FDG PET/CT in Anti-NMDA Receptor Encephalitis

2018 ◽  
Vol 43 (7) ◽  
pp. 520-521 ◽  
Author(s):  
Abdenasser Moubtakir ◽  
Sébastien Dejust ◽  
François Godard ◽  
Leila Messaoud ◽  
David Morland
Keyword(s):  
Nmda Receptor ◽  
Fdg Pet ◽  
Nmda Receptor Encephalitis ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Impact of 18F-FDG PET/CT in Predicting Recurrence in Neurolymphomatosis

Hemato ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 596-606
Author(s):  
Megumi Uemichi ◽  
Kota Yokoyama ◽  
Junichi Tsuchiya ◽  
Toshiki Terao ◽  
Youichi Machida ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Medical Center ◽  
Clinical Findings ◽  
University Hospital ◽  
Nerve Lesions ◽  
Positron Emission ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Tokyo Medical

To clarify the prognostic value of 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in Neurolymphomatosis (NL), we retrospectively reviewed medical records of all NL patients who had undergone 18F-FDG PET/CT from 2007 to 2020 at Kameda Medical Center and Tokyo Medical and Dental University Hospital. The clinical data of patients were compared with 18F-FDG PET/CT findings of number of nerve lesions and presence of non-nerve extranodal lesions (ENL). Subsequently, we calculated recurrence-free survival (RFS) and overall survival (OS) using the Kaplan–Meier method. A total of 28 patients (mean age 70.1 years, range 44–87 years; 15 women) were included in the study and 7 patients (25.0%) relapsed NL. The number of nerve lesions detected by 18F-FDG PET/CT ranged from 1 to 5, with an average of 2.02. ENL was observed in 18 cases (64.3%). The comparison between the findings revealed that the more the lesions detected by 18F-FDG PET/CT, the higher the probability of recurrence (χ2 = 13.651, p = 0.0085) and there was significantly shorter RFS for the patients with 3 or more nerve lesions (p = 0.0059), whereas the presence of ENL was not significantly associated with any clinical findings. The present study revealed that the more nerve lesions detected by 18F-FDG PET/CT, the poorer the recurrence rate and RFS.

The Clinical Utility of FDG PET-CT in Evaluation of Bone Marrow Involvement by Diffuse Large B Cell Lymphoma

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 2661-2661
Author(s):  
Hyo Jung Kim ◽  
Boram Han ◽  
Dok Hyun Yoon ◽  
Ho Young Kim ◽  
Shin Kim ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Fdg Pet ◽  
Iliac Crest ◽  
Cell Lymphoma ◽  
Medical Center ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Large B Cell

Abstract Abstract 2661 Background. In lymphoma, bone marrow (BM) involvement is a sign of extensive disease and BM biopsy is a standard method in the evaluation of BM infiltration by disease. Because of patchy BM involvement pattern by lymphoma, the reported rates of unilateral involvement in bilateral biopsies range from 10% to 50%. However BM biopsy is an invasive and painful procedure. The value of unilateral versus bilateral BM biopsy remains controversial. Fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) is a noninvasive imaging technique and currently it shows potential to detect BM involvement by lymphoma. Aims. We assess the abilities of FDG PET-CT to ascertain the presence of BM involvement in diffuse large B cell lymphoma (DLBCL) patients and to define the possibility that bilateral BM biopsies could be replaced by unilateral biopsy for DLBCL staging workup. Methods. We retrospectively reviewed medical records of histologically proven DLBCL patients from 2004 through 2010 at the Asan Medical Center and Hallym University Medical Center. All patients were examined by FDG PET-CT and bilateral BM biopsy at both posterior iliac crests for initial staging workup. Evaluation of PET studies was performed by board-certified nuclear medicine physicians of each institution. Quantitative analysis of FDG uptake was not performed. Data were expressed in terms of sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for FDG PET-CT in evaluation of BM involvement by DLBCL, using BM biopsy as the reference standard. Two sets (right & left biopsy site) of pathologic and imaging data were analyzed separately. Results. Study population comprised 478 patients (median age 57, range 17–85 years; 269 male) with newly diagnosed DLBCL. Ann Arbor stage I, II, III and IV patients were 96, 120, 40 and 222, respectively. Overall, BM involvement by DLBCL that confirmed by bilateral BM biopsy occurred in 63 patients (13.2%, 15, 12, and 36 at right, left and both side biopsy, respectively). From the data of right side biopsy and FDG PET-CT images, comparison of the former and the later results revealed concordant positive findings in 22 cases (4.6%) and concordant negative findings in another 418 cases (87.4%). In 29 patients (6.1%) in whom FDG PET-CT returned findings of normal marrow, iliac crest BM biopsy revealed lymphomatous infiltration. On the other hand, in 9 patients (1.9%) in whom bilateral iliac crest BM biopsy had failed to reveal any abnormality, FDG PET-CT showed increased uptake. The calculated values for FDG PET-CT in evaluation of right BM infiltration were 43.1% (22/51) of sensitivity, 97.9% (418/427) of specificity, 71% (22/31) of PPV and 93.5% (418/447) of NPV. The values oriented from left BM biopsy and FDG PET-CT images were similar (sensitivity 41.7% (20/48), specificity 97.9% (421/430), PPV 69% (20/29), NPV 93.7% (421/449)). Conclusions. This study has the largest DLBCL cases among ever reported articles, and demonstrates not excellent sensitivity of FDG PET-CT against the results of BM biopsy for the detection of BM involvement in DLBCL patients. BM biopsy could not be completely replaced with FDG PET-CT. But it has relatively good PPV, FDG PET-CT will be a useful tool for image-guided biopsy for DLBCL staging. And in daily practice, clinicians could consider the possibility to do efficient unilateral BM biopsy for DLBCL patients who have increased posterior iliac crest FDG uptake, instead of bilateral biopsy. Disclosures: Kim: Novartis: Research Funding.

Serial FDG PET/CT in Autoimmune Encephalitis With Faciobrachial Dystonic Seizures

2014 ◽  
Vol 39 (10) ◽  
pp. e436-e438 ◽  
Author(s):  
Albrecht Kunze ◽  
Robert Drescher ◽  
Katharina Kaiser ◽  
Martin Freesmeyer ◽  
Otto W. Witte ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Autoimmune Encephalitis ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Diagnostic Value of 18 F-FDG PET/CT Versus MRI in the Setting of Antibody-Specific Autoimmune Encephalitis

2017 ◽  
Vol 58 (8) ◽  
pp. 1307-1313 ◽  
Author(s):  
Lilja B. Solnes ◽  
Krystyna M. Jones ◽  
Steven P. Rowe ◽  
Puskar Pattanayak ◽  
Abhinav Nalluri ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Autoimmune Encephalitis ◽  
Diagnostic Value ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Abnormal brain metabolism on FDG-PET/CT is a common early finding in autoimmune encephalitis

2017 ◽  
Vol 4 (4) ◽  
pp. e352 ◽  
Author(s):  
John C. Probasco ◽  
Lilja Solnes ◽  
Abhinav Nalluri ◽  
Jesse Cohen ◽  
Krystyna M. Jones ◽  
...  
Keyword(s):  
Brain Region ◽  
Fdg Pet ◽  
Brain Metabolism ◽  
Brain Mri ◽  
Autoimmune Encephalitis ◽  
Pet Ct ◽  
Tertiary Center ◽  
Fdg Pet Ct ◽  
Abnormal Brain ◽  
Ct Studies

Objective:To compare the rate of abnormal brain metabolism by FDG-PET/CT to other paraclinical findings and to describe brain metabolism patterns in autoimmune encephalitis (AE).Methods:A retrospective review of clinical data and initial dedicated brain FDG-PET/CT studies for neurology inpatients with AE, per consensus criteria, treated at a single tertiary center over 123 months. Z-score maps of FDG-PET/CT were made using 3-dimensional stereotactic surface projections with comparison to age group–matched controls. Brain region mean Z-scores with magnitudes ≥2.00 were interpreted as significant. Comparisons were made to rates of abnormal initial brain MRI, abnormal initial EEG, and presence of intrathecal inflammation.Results:Sixty-one patients with AE (32 seropositive) underwent brain FDG-PET/CT at median 4 weeks of symptoms (interquartile range [IQR] 9 weeks) and median 4 days from MRI (IQR 8.5 days). FDG-PET/CT was abnormal in 52 (85%) patients, with 42 (69%) demonstrating only hypometabolism. Isolated hypermetabolism was demonstrated in 2 (3%) patients. Both hypermetabolic and hypometabolic brain regions were noted in 8 (13%) patients. Nine (15%) patients had normal FDG-PET/CT studies. CSF inflammation was evident in 34/55 (62%) patients, whereas initial EEG (17/56, 30%) and MRI (23/57, 40%) were abnormal in fewer. Detection of 2 or more of these paraclinical findings was in weak agreement with abnormal brain FDG-PET/CT (κ = 0.16, p = 0.02).Conclusions:FDG-PET/CT was more often abnormal than initial EEG, MRI, and CSF studies in neurology inpatients with AE, with brain region hypometabolism the most frequently observed.

scholarly journals FDG-PET/CT patterns in patients with autoimmune encephalitis: a series of 9 cases

2021 ◽  
Author(s):  
Maria Eduarda Slhessarenko Fraife Barreto ◽  
Guilherme de Carvalho Campos ◽  
Bruna Letícia Ferrari ◽  
Lívia Almeida Dutra
Keyword(s):  
Fdg Pet ◽  
Brain Mri ◽  
Autoimmune Encephalitis ◽  
Albert Einstein ◽  
Cross Sectional Study ◽  
Cognitive Changes ◽  
Cross Sectional ◽  
Pet Ct ◽  
Fdg Pet Ct

Background: Autoimmune encephalitis (AIE) is the main differential diagnosis of infectious encephalitis. Brain MRI is normal in up to 50% of cases and studies indicate that changes in FDG-PET/CT are more frequent and early. Objectives: To describe FDG-PET/CT findings in patients with AIE of Hospital Israelita Albert Einstein (HIAE) from 2015-2020. Design and setting: Retrospective cross-sectional study at HIAE. Methods: Medical records of patients with suspected AIE were reviewed. Laboratory results were compiled, and images were reassessed. Results: Amongst 250 records, we found 7.6% (n=19) of AIE, being 8 seropositive (5 anti-NMDA, 1 anti-CASPR2, 1 anti-MOG, 1 anti-VGKC and 1 anti-LGI1), 5 seronegative and 4 limbic encephalitis. The mean age was 48-22 years, 52% male. In encephalitic patients, the most common manifestations were epilepsy (78%), cognitive changes (63%), and behavioral changes (63%). Only 57% had abnormal MRI. We evaluated 23 PET/CTs at different stages of treatment; of the 9 FDG-PET/CTs performed at initial presentation, 88% were abnormal and 30% had normal MRI. Most frequent patterns found were hypometabolism in frontal (59.1%), temporal (39.1%) and left parietal (39.1%) regions. In follow-up, only 2 patients normalized FDG-PET/CT, with clinical improvement. Conclusions:FDG-PET/CT was altered in 88% of patients. In this series, no typical PET/CT pattern was demonstrated for AIE; the most frequent findings were hypometabolism in cortical areas, which also occur in degenerative diseases. We did not find hypermetabolism, or mixed areas of hypo- and hypermetabolism. The specificity of PET/CT for AIE diagnosis should be evaluated in future studies.

Integrated FDG-PET/CT for initial staging of breast cancer

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 558-558 ◽  
Author(s):  
Q. J. Khan ◽  
A. P. O’Dea ◽  
R. Dusing ◽  
P. Sharma ◽  
S. M. Roling ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Disease ◽  
Invasive Breast Cancer ◽  
False Positive ◽  
Fdg Pet ◽  
Medical Center ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Initial Staging

558 Background: Integrated FDG-PET/CT improves the diagnostic accuracy of staging of some cancers. The value of FDG-PET/CT in initial staging of breast cancer for detection of distant metastases has not been defined. Methods: Retrospective analysis of 83 consecutive women at the University of Kansas Medical Center who had a FDG-PET/CT from Jan 2005 to July 2006, at the time of initial diagnosis of invasive breast cancer. Women with symptoms suspicious for metastatic disease were excluded. Radiographic reports and patient charts were reviewed. All suspicious CT scans were re-read by a single radiologist who was blinded to the PET results. All suspicious scans were confirmed either by a biopsy or follow-up scans according to the discretion of the treating physician. Results: Median age was 52. 23 (28%) cancers were stage I, 44 (53%) stage II and 16 (19%) were stage III. 15/83 (18%) women had a suspicious FDG-PET/CT. Only 2 of these 15 women were confirmed to have metastatic disease, while 13 (16 %) had a false positive (FP) scan. In 5 women where both CT and PET were suspicious, 2 were true positives (TP) whereas 3 were FP. All 3 women who had suspicious PET but a non-suspicious CT were FP. All 7 women who had a non-suspicious PET and a suspicious CT were FP. PET influenced the CT classification by the radiologist in 5 (6%) women. 71/83 (86%) women had a negative or a non-suspicious CT. 3 women had lesions classified as non-suspicious with the help of a negative PET, two had lesions classified as suspicious with the help of a positive PET and seven had suspicious lesions on CT regardless of the PET. FDG-PET/CT resulted in unnecessary follow-up scans in eleven women, and unnecessary biopsies in two. One TP had metastatic bone disease. The other TP had a solitary liver metastasis detected by FDG-PET/CT which was resected and she has no evidence of disease after two years of follow-up. Conclusions: Given the high false positive rate and overall low incidence of metastases, routine use of FDG- PET/CT in asymptomatic women diagnosed with invasive breast cancer cannot be recommended. No significant financial relationships to disclose.

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