Clinical and striatal dopamine transporter predictors of β-amyloid in dementia with Lewy bodies

Neurology ◽  
2020 ◽  
Vol 94 (13) ◽  
pp. e1344-e1352 ◽  
Author(s):  
Han Soo Yoo ◽  
Sangwon Lee ◽  
Seok Jong Chung ◽  
Yang Hyun Lee ◽  
Byoung Seok Ye ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Dementia With Lewy Bodies ◽  
Ventral Striatum ◽  
Neuropsychiatric Symptoms ◽  
Brain Mri ◽  
Lewy Bodies ◽  
Striatal Dopamine ◽  
Neuropsychological Profile ◽  
Younger Age ◽  
Β Amyloid

ObjectiveTo investigate the relationship between β-amyloid (Aβ) deposition and striatal dopamine depletion, cognitive functions, and neuropsychiatric symptoms in dementia with Lewy bodies (DLB).MethodsWe consecutively recruited 51 patients with DLB who had undergone a neuropsychological test, Neuropsychiatric Inventory assessment, brain MRI, N-(3-[18F]fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) PET, and 18F-florbetaben PET within 6 months. The patients were divided into Aβ-negative (DLB-Aβ−, n = 20) and Aβ-positive (DLB-Aβ+, n = 31) groups according to the brain amyloid plaque load score. We performed comparative analyses of dopamine transporter (DAT) activity, neuropsychological profile, and neuropsychiatric symptoms between the 2 groups.ResultsCompared to the DLB-Aβ− group, the DLB-Aβ+ group had a younger age at diagnosis (p = 0.017), poorer performance in attention (p = 0.028) and visuospatial (p = 0.006) functions, and higher proportion of anxiety (p = 0.006) and total neuropsychiatric burden (p = 0.013). Those in the DLB-Aβ+ group also had lower DAT activity in the anterior putamen (p = 0.015) and ventral striatum (p = 0.006) regardless of age, sex, and years of education. In addition, lower DAT activity in the ventral striatum was significantly associated with anxiety and total neuropsychiatric burden in DLB.ConclusionsThis study demonstrated that Aβ deposition in DLB is associated with diagnosis at a younger age, higher cognitive and neuropsychiatric burden, and decreased DAT activity, suggesting that evaluation of clinical features and DAT activity can predict the presence of Aβ in DLB.

Striatal dopamine transporter function in dementia with Lewy bodies and Parkinson's disease

2001 ◽  
Vol 28 (10) ◽  
pp. 1523-1528 ◽  
Author(s):  
Gerhard Ransmayr ◽  
Klaus Seppi ◽  
Eveline Donnemiller ◽  
Elisabeth Luginger ◽  
Josef Marksteiner ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Transporter ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Striatal Dopamine

scholarly journals Striatal Dopamine Transporter Binding Does Not Correlate with Clinical Severity in Dementia with Lewy Bodies

2013 ◽  
Vol 54 (7) ◽  
pp. 1072-1076 ◽  
Author(s):  
M. Ziebell ◽  
B. B. Andersen ◽  
L. H. Pinborg ◽  
G. M. Knudsen ◽  
J. Stokholm ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Clinical Severity ◽  
Striatal Dopamine

Severity of neuropsychiatric symptoms and dopamine transporter levels in dementia with Lewy bodies: A 123 I-FP-CIT SPECT study

2009 ◽  
Vol 24 (14) ◽  
pp. 2097-2103 ◽  
Author(s):  
Francesco Roselli ◽  
Nicola M. Pisciotta ◽  
Robert Perneczky ◽  
Michele Pennelli ◽  
Maria S. Aniello ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Dementia With Lewy Bodies ◽  
Neuropsychiatric Symptoms ◽  
Lewy Bodies

Striatal dopamine transporter in dementia with Lewy bodies and Parkinson disease

Neurology ◽  
2004 ◽  
Vol 62 (9) ◽  
pp. 1568-1572 ◽  
Author(s):  
Z. Walker ◽  
D. C. Costa ◽  
R. W.H. Walker ◽  
L. Lee ◽  
G. Livingston ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Dopamine Transporter ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Striatal Dopamine

Prodromal Dementia With Lewy Bodies: Evolution of Symptoms and Predictors of Dementia Onset

2021 ◽  
pp. 089198872110235
Author(s):  
Kathryn A. Wyman-Chick ◽  
Lauren R. O’Keefe ◽  
Daniel Weintraub ◽  
Melissa J. Armstrong ◽  
Michael Rosenbloom ◽  
...  
Keyword(s):  
Clinical Features ◽  
Dementia With Lewy Bodies ◽  
Clinical Symptoms ◽  
Neuropsychiatric Symptoms ◽  
Lewy Bodies ◽  
Rem Sleep Behavior Disorder ◽  
Data Set ◽  
Wide Range ◽  
Prodromal Dementia ◽  
Dementia Onset

Background: Research criteria for prodromal dementia with Lewy bodies (DLB) were published in 2020, but little is known regarding prodromal DLB in clinical settings. Methods: We identified non-demented participants without neurodegenerative disease from the National Alzheimer’s Coordinating Center Uniform Data Set who converted to DLB at a subsequent visit. Prevalence of neuropsychiatric and motor symptoms were examined up to 5 years prior to DLB diagnosis. Results: The sample included 116 participants clinically diagnosed with DLB and 348 age and sex-matched (1:3) Healthy Controls. Motor slowing was present in approximately 70% of participants 3 years prior to DLB diagnosis. In the prodromal phase, 50% of DLB participants demonstrated gait disorder, 70% had rigidity, 20% endorsed visual hallucinations, and over 50% of participants endorsed REM sleep behavior disorder. Apathy, depression, and anxiety were common prodromal neuropsychiatric symptoms. The presence of 1+ core clinical features of DLB in combination with apathy, depression, or anxiety resulted in the greatest AUC (0.815; 95% CI: 0.767, 0.865) for distinguishing HC from prodromal DLB 1 year prior to diagnosis. The presence of 2+ core clinical features was also accurate in differentiating between groups (AUC = 0.806; 95% CI: 0.756, 0.855). Conclusion: A wide range of motor, neuropsychiatric and other core clinical symptoms are common in prodromal DLB. A combination of core clinical features, neuropsychiatric symptoms and cognitive impairment can accurately differentiate DLB from normal aging prior to dementia onset.

scholarly journals Levodopa-induced dyskinesia in dementia with Lewy bodies and Parkinson disease with dementia

2019 ◽  
Vol 10 (2) ◽  
pp. 156-161
Author(s):  
Pierpaolo Turcano ◽  
Cole D. Stang ◽  
James H. Bower ◽  
J. Eric Ahlskog ◽  
Bradley F. Boeve ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Population Based ◽  
Olmsted County ◽  
Levodopa Dosage ◽  
Younger Age ◽  
Increased Risk ◽  
Incident Cohort ◽  
Median Interval

ObjectiveTo investigate the frequency of levodopa-induced dyskinesia in dementia with Lewy bodies (DLBs) and Parkinson disease with dementia (PDD) and compare these frequencies with patients with incident Parkinson disease (PD) through a population-based cohort study.MethodsWe identified all patients with DLB, PDD, and PD without dementia in a 1991–2010 population-based parkinsonism-incident cohort, in Olmsted County, Minnesota. We abstracted information about levodopa-induced dyskinesia. We compared patients with DLB and PDD with dyskinesia with patients with PD from the same cohort.ResultsLevodopa use and dyskinesia data were available for 141/143 (98.6%) patients with a diagnosis of either DLB or PDD; 87 (61.7%), treated with levodopa. Dyskinesia was documented in 12.6% (8 DLB and 3 PDD) of levodopa-treated patients. Among these patients, median parkinsonism diagnosis age was 74 years (range: 64–80 years); 63.6%, male. The median interval from levodopa initiation to dyskinesia onset was 2 years (range: 3 months–4 years); the median daily levodopa dosage was 600 mg (range: 50–1,600 mg). Dyskinesia severity led to levodopa adjustments in 5 patients, and all improved. Patients with dyskinesia were diagnosed with parkinsonism at a significantly younger age compared with patients without dyskinesia (p < 0.001). Levodopa dosage was unrelated to increased risk of dyskinesias among DLB and PDD. In contrast, 30.1% of levodopa-treated patients with PD developed dyskinesia. In age-, sex-, and levodopa dosage–adjusted models, Patients with DLB and PDD each had lower odds of developing dyskinesia than patients with PD (odds ratio = 0.42, 95% CI 0.21–0.88; p = 0.02).ConclusionsThe dyskinesia risk for levodopa-treated patients with DLB or PDD was substantially less than for levodopa-treated patients with PD.

Ultrabrief Right Unilateral Electroconvulsive Therapy for the Treatment of the Neuropsychiatric Symptoms of Dementia with Lewy Bodies

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Adriana P. Hermida ◽  
Evelina Sterina ◽  
P. Parker Schwab ◽  
Cody Michael Browning ◽  
Hannah M. Chapman ◽  
...  
Keyword(s):  
Electroconvulsive Therapy ◽  
Dementia With Lewy Bodies ◽  
Neuropsychiatric Symptoms ◽  
Lewy Bodies
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