scholarly journals Detection of Cerebral Microbleeds With Venous Connection at 7 Tesla MRI

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000011790
Author(s):  
Johanna Rotta ◽  
Valentina Perosa ◽  
Renat Yakupov ◽  
Hugo J Kuijf ◽  
Frank Schreiber ◽  
...  
Keyword(s):  
Small Vessel Disease ◽  
Cerebral Microbleeds ◽  
7 Tesla ◽  
Common Finding ◽  
Amyloid Angiopathy ◽  
Healthy Elderly ◽  
7 Tesla Mri ◽  
Healthy Elderly People

Objective:Cerebral microbleeds (MBs) are a common finding in cerebral small vessel disease (CSVD) and Alzheimer’s disease patients as well as in healthy elderly people, but their pathophysiology remains unclear. To investigate a possible role of veins in the development of MBs, we performed an exploratory study, assessing in vivo presence of MBs with a direct connection to a vein.Methods:7 Tesla (7 T) MRI was conducted and MBs were counted on Quantitative Susceptibility Mapping (QSM). A submillimeter resolution QSM-based venogram allowed identification of MBs with a direct spatial connection to a vein.Results:51 subjects (mean age [SD] 70.5[8.6] years, 37% females) participated in the study: 20 were patients with CSVD (cerebral amyloid angiopathy (CAA) with strictly lobar MBs (n=8), hypertensive arteriopathy (HA) with strictly deep MBs (n=5), and mixed lobar and deep MBs (n=7), 72.4 [6.1] years, 30% females) and 31 were healthy controls (69.4 [9.9] years, 42% females). In our cohort, we counted a total of 96 MBs with a venous connection, representing 14% of all detected MBs on 7T QSM. Most venous MBs (86%, n = 83) were observed in lobar locations and all of these were cortical. CAA subjects showed the highest ratio of venous to total MBs (19%) (HA=9%, mixed=18%, controls=5%)Conclusions:Our findings establish a link between cerebral MBs and the venous vasculature, pointing towards a possible contribution of veins to CSVD in general and to CAA in particular. Pathological studies are needed to confirm our observations.

scholarly journals Contrast leakage distant from the hematoma in patients with spontaneous ICH: A 7 T MRI study

2019 ◽  
Vol 40 (5) ◽  
pp. 1002-1011 ◽  
Author(s):  
Wilmar MT Jolink ◽  
Arjen Lindenholz ◽  
Ellis S van Etten ◽  
Koen M van Nieuwenhuizen ◽  
Floris HBM Schreuder ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
7 Tesla ◽  
Amyloid Angiopathy ◽  
Vessel Disease ◽  
7 Tesla Mri ◽  
Cerebral Amyloid ◽  
Mri Study ◽  
3D Flair

Disruption of the blood–brain barrier (BBB) might play a role in the pathophysiology of cerebral small vessel disease-related ICH. The aim of this study was to assess presence and extent of contrast agent leakage distant from the hematoma as a marker of BBB disruption in patients with spontaneous ICH. We prospectively performed 7 tesla MRI in adult patients with spontaneous ICH and assessed contrast leakage distant from the hematoma on 3D FLAIR images. Thirty-one patients were included (mean age 60 years, 29% women). Median time between ICH and MRI was 20 days (IQR 9–67 days). Seventeen patients (54%; seven lobar, nine deep, one infratentorial ICH) had contrast leakage, located cortical in 16 and cortical and deep in one patient. Patients with contrast leakage more often had lobar cerebral microbleeds (CMBs; 77%) than those without (36%; RR 2.5, 95% CI 1.1–5.7) and a higher number of lobar CMBs (patients with contrast leakage: median 2, IQR 1–8 versus those without: median 0, IQR 0–2; p = 0.02). This study shows that contrast leakage distant from the hematoma is common in days to weeks after spontaneous ICH. It is located predominantly cortical and related to lobar CMBs and therefore possibly to cerebral amyloid angiopathy.

scholarly journals A probabilistic atlas of the human ventral tegmental area (VTA) based on 7 Tesla MRI data

2021 ◽  
Vol 226 (4) ◽  
pp. 1155-1167 ◽  
Author(s):  
Anne C. Trutti ◽  
Laura Fontanesi ◽  
Martijn J. Mulder ◽  
Pierre-Louis Bazin ◽  
Bernhard Hommel ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Region Of Interest ◽  
Reward Processing ◽  
7 Tesla ◽  
Subcortical Structures ◽  
7 Tesla Mri ◽  
Subcortical Nuclei ◽  
Ventral Tegmental ◽  
The Brain

AbstractFunctional magnetic resonance imaging (fMRI) BOLD signal is commonly localized by using neuroanatomical atlases, which can also serve for region of interest analyses. Yet, the available MRI atlases have serious limitations when it comes to imaging subcortical structures: only 7% of the 455 subcortical nuclei are captured by current atlases. This highlights the general difficulty in mapping smaller nuclei deep in the brain, which can be addressed using ultra-high field 7 Tesla (T) MRI. The ventral tegmental area (VTA) is a subcortical structure that plays a pivotal role in reward processing, learning and memory. Despite the significant interest in this nucleus in cognitive neuroscience, there are currently no available, anatomically precise VTA atlases derived from 7 T MRI data that cover the full region of the VTA. Here, we first provide a protocol for multimodal VTA imaging and delineation. We then provide a data description of a probabilistic VTA atlas based on in vivo 7 T MRI data.

scholarly journals P4-078: REPRESENTATION OF BLOOD FLOW IN PERFORATING BASAL GANGLIA ARTERIES OF PATIENTS WITH CEREBRAL SMALL VESSEL DISEASE (CSVD) AT 7 TESLA MRI

2019 ◽  
Vol 15 ◽  
pp. P1304-P1304
Author(s):  
Valentina Perosa ◽  
Emrah Düzel ◽  
Tine Arts ◽  
Stefanie Schreiber ◽  
Anne Assmann ◽  
...  
Keyword(s):  
Blood Flow ◽  
Basal Ganglia ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
7 Tesla ◽  
Vessel Disease ◽  
7 Tesla Mri

scholarly journals Quantifying the contrast of the human locus coeruleus in vivo at 7 Tesla MRI

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0209842 ◽  
Author(s):  
Klodiana-Daphne Tona ◽  
Matthias J. P. van Osch ◽  
Sander Nieuwenhuis ◽  
Max C. Keuken
Keyword(s):  
Locus Coeruleus ◽  
7 Tesla ◽  
7 Tesla Mri

scholarly journals In Vivo High-Resolution 7 Tesla MRI Shows Early and Diffuse Cortical Alterations in CADASIL

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e106311 ◽  
Author(s):  
François De Guio ◽  
Sonia Reyes ◽  
Alexandre Vignaud ◽  
Marco Duering ◽  
Stefan Ropele ◽  
...  
Keyword(s):  
High Resolution ◽  
7 Tesla ◽  
7 Tesla Mri

The Emerging Role of 7 Tesla MRI in Musculoskeletal Imaging

2018 ◽  
Vol 6 (8) ◽  
Author(s):  
Rajiv G. Menon ◽  
Gregory Chang ◽  
Ravinder R. Regatte
Keyword(s):  
Musculoskeletal Imaging ◽  
7 Tesla ◽  
7 Tesla Mri

scholarly journals In-vivo and numerical analysis of the eigenmodes produced by a multi-level Tic-Tac-Toe head transmit array for 7 Tesla MRI

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0206127 ◽  
Author(s):  
Tales Santini ◽  
Yujuan Zhao ◽  
Sossena Wood ◽  
Narayanan Krishnamurthy ◽  
Junghwan Kim ◽  
...  
Keyword(s):  
Numerical Analysis ◽  
7 Tesla ◽  
7 Tesla Mri ◽  
Multi Level

Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment

2013 ◽  
Vol 73 (5) ◽  
pp. 584-593 ◽  
Author(s):  
Jae-Hyun Park ◽  
Sang Won Seo ◽  
Changsoo Kim ◽  
Geon Ha Kim ◽  
Hyun Jin Noh ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
In Vivo Imaging ◽  
Small Vessel Disease ◽  
Cerebral Microbleeds ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Cerebral Microbleeds and White Matter Hyperintensities in Cognitively Healthy Elderly: A Cross-Sectional Cohort Study Evaluating the Effect of Arterial Stiffness

2015 ◽  
Vol 5 (2) ◽  
pp. 41-51 ◽  
Author(s):  
Anna-Märta Gustavsson ◽  
Erik Stomrud ◽  
Kasim Abul-Kasim ◽  
Lennart Minthon ◽  
Peter M. Nilsson ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Arterial Stiffness ◽  
White Matter Hyperintensities ◽  
Small Vessel Disease ◽  
Cerebral Microbleeds ◽  
Small Vessel ◽  
Cognitive Tests ◽  
Vessel Disease ◽  
Healthy Elderly

Background: Arterial stiffness reflects the ageing processes in the vascular system, and studies have shown an association between reduced cognitive function and cerebral small vessel disease. Small vessel disease can be visualized as white matter hyperintensities (WMH) and lacunar infarcts but also as cerebral microbleeds on brain magnetic resonance imaging (MRI). We aimed to investigate if arterial stiffness influences the presence of microbleeds, WMH and cognitive function in a population of cognitively healthy elderly. Methods: The study population is part of the Swedish BioFinder study and consisted of 208 individuals without any symptoms of cognitive impairment, who scored >27 points on the Mini-Mental State Examination. The participants (mean age, 72 years; 59% women) underwent MRI of the brain with visual rating of microbleeds and WMH. Arterial stiffness was measured with carotid-femoral pulse wave velocity (cfPWV). Eight cognitive tests covering different cognitive domains were performed. Results: Microbleeds were detected in 12% and WMH in 31% of the participants. Mean (±standard deviation, SD) cfPWV was 10.0 (±2.0) m/s. There was no association between the presence of microbleeds and arterial stiffness. There was a positive association between arterial stiffness and WMH independent of age or sex (odds ratio, 1.58; 95% confidence interval, 1.04-2.40, p < 0.05), but the effect was attenuated when further adjustments for several cardiovascular risk factors were performed (p > 0.05). Cognitive performance was not associated with microbleeds, but individuals with WMH performed slightly worse than those without WMH on the Symbol Digit Modalities Test (mean ± SD, 35 ± 7.8 vs. 39 ± 8.1, p < 0.05). Linear regression revealed no direct associations between arterial stiffness and the results of the cognitive tests. Conclusions: Arterial stiffness was not associated with the presence of cerebral microbleeds or cognitive function in cognitively healthy elderly. However, arterial stiffness was related to the presence of WMH, but the association was attenuated when multiple adjustments were made. There was a weak negative association between WMH and performance in one specific test of attention. Longitudinal follow-up studies are needed to further assess the associations.

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