A Combination of Mild Hypothermia and Sevoflurane Affords Long-Term Protection in a Modified Neonatal Mouse Model of Cerebral Hypoxia-Ischemia

2014 ◽  
Vol 119 (5) ◽  
pp. 1158-1173 ◽  
Author(s):  
Erica P. Lin ◽  
Lili Miles ◽  
Elizabeth A. Hughes ◽  
John C. McCann ◽  
Charles V. Vorhees ◽  
...  
Keyword(s):  
Mouse Model ◽  
Mild Hypothermia ◽  
Neonatal Mouse ◽  
Cerebral Hypoxia ◽  
Hypoxia Ischemia

Neuroprotective Effect of Long-term MgSO4 Administration After Cerebral Hypoxia-Ischemia in Newborn Rats Is Related to the Severity of Brain Damage

2007 ◽  
Vol 14 (7) ◽  
pp. 667-677 ◽  
Author(s):  
Evangelia Spandou ◽  
Vassiliki Soubasi ◽  
Stamatia Papoutsopoulou ◽  
Persefoni Augoustides-Savvopoulou ◽  
Theodoros Loizidis ◽  
...  
Keyword(s):  
Brain Damage ◽  
Neuroprotective Effect ◽  
Cerebral Hypoxia ◽  
Newborn Rats ◽  
Hypoxia Ischemia

NF-κB inhibition after neonatal cerebral hypoxia–ischemia improves long-term motor and cognitive outcome in rats

2010 ◽  
Vol 38 (2) ◽  
pp. 266-272 ◽  
Author(s):  
Michael A. van der Kooij ◽  
Cora H. Nijboer ◽  
Frauke Ohl ◽  
Floris Groenendaal ◽  
Cobi J. Heijnen ◽  
...  
Keyword(s):  
Cognitive Outcome ◽  
Cerebral Hypoxia ◽  
Hypoxia Ischemia

Intraischemic mild hypothermia prevents neuronal cell death and tissue loss after neonatal cerebral hypoxia-ischemia

2006 ◽  
Vol 23 (2) ◽  
pp. 387-393 ◽  
Author(s):  
Changlian Zhu ◽  
Xiaoyang Wang ◽  
Falin Xu ◽  
Lin Qiu ◽  
Xiuyong Cheng ◽  
...  
Keyword(s):  
Cell Death ◽  
Mild Hypothermia ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Tissue Loss ◽  
Cerebral Hypoxia ◽  
Hypoxia Ischemia

scholarly journals Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Victor Manuel Blanco-Alvarez ◽  
Guadalupe Soto-Rodriguez ◽  
Juan Antonio Gonzalez-Barrios ◽  
Daniel Martinez-Fong ◽  
Eduardo Brambila ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Growth Factors ◽  
Neural Plasticity ◽  
Memory Loss ◽  
Male Rats ◽  
Long Term Memory ◽  
Cerebral Hypoxia ◽  
Term Memory ◽  
Hypoxia Ischemia

Prophylactic subacute administration of zinc decreases lipoperoxidation and cell death following a transient cerebral hypoxia-ischemia, thus suggesting neuroprotective and preconditioning effects. Chemokines and growth factors are also involved in the neuroprotective effect in hypoxia-ischemia. We explored whether zinc prevents the cerebral cortex-hippocampus injury through regulation of CCL2, CCR2, FGF2, and IGF-1 expression following a 10 min of common carotid artery occlusion (CCAO). Male rats were grouped as follows: (1) Zn96h, rats injected with ZnCl2(one dose every 24 h during four days); (2) Zn96h + CCAO, rats treated with ZnCl2before CCAO; (3) CCAO, rats with CCAO only; (4) Sham group, rats with mock CCAO; and (5) untreated rats. The cerebral cortex-hippocampus was dissected at different times before and after CCAO. CCL2/CCR2, FGF2, and IGF-1 expression was assessed by RT-PCR and ELISA. Learning in Morris Water Maze was achieved by daily training during 5 days. Long-term memory was evaluated on day 7 after learning. Subacute administration of zinc increased expression of CCL2, CCR2, FGF2, and IGF-1 in the early and late phases of postreperfusion and prevented the CCAO-induced memory loss in the rat. These results might be explained by the induction of neural plasticity because of the expression of CCL2 and growth factors.

Oxygen treatment after perinatal hypoxia-ischemia reduces neuronal damage at short survival times, but worsens injury with long-term survival

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S444-S444 ◽  
Author(s):  
Kristin M Noppens ◽  
J Regino Perez-Polo ◽  
David K Rassin ◽  
Karin N Westlund ◽  
Roderic Fabian ◽  
...  
Keyword(s):  
Neuronal Damage ◽  
Perinatal Hypoxia ◽  
Survival Times ◽  
Term Survival ◽  
Long Term Survival ◽  
Short Survival ◽  
Oxygen Treatment ◽  
Hypoxia Ischemia
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