Giant Granular Cell Tumor of the Suprasellar Area; Immunocytochemical and Electron Microscopic Studies

Neurosurgery ◽  
1984 ◽  
Vol 15 (2) ◽  
pp. 246-251 ◽  
Author(s):  
Boleslaw H. Liwnicz ◽  
Boleslaw H. Liwnicz ◽  
Regina G. Liwnicz ◽  
Stephen J. Huff ◽  
Bert H. McBride ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Granular Cell Tumor ◽  
Periodic Acid ◽  
Granular Cell ◽  
Cell Tumor ◽  
Electron Microscopic ◽  
Periodic Acid Schiff ◽  
Computed Tomographic ◽  
Suprasellar Region ◽  
Microscopic Studies

Abstract We describe a case of a granular cell tumor (GCT) of the suprasellar region with an 11-year history in a 26-year-old woman. The computed tomographic scan showed a midline, contrast-enhancing, noncalcified mass. The biopsy was diagnosed as GCT. The tumor was treated with radiation therapy. At necropsy, a large, homogeneous GCT surrounded by gliosis was found. The tumor cells were filled with granules positive for periodic acid-Schiff, diastase-resistant. The cells did not contain glial fibrillary acidic protein or S-100 protein. Electron microscopy showed tumor cells filled with innumerable lysosomal structures. No intermediate filament was found within the cytoplasm. The tumor cells were not surrounded by a basement membrane. Based on this study and on our review of the literature, the suggestion that GCT has a multicellular origin is upheld.

scholarly journals Atypical meningeal granular cell tumor in a dog

2011 ◽  
Vol 24 (1) ◽  
pp. 192-197 ◽  
Author(s):  
Sasmita Mishra ◽  
Marc Kent ◽  
Allison Haley ◽  
Simon Platt ◽  
Kaori Sakamoto
Keyword(s):  
Cerebral Hemisphere ◽  
Granular Cell Tumor ◽  
Periodic Acid ◽  
Granular Cell ◽  
Cell Tumor ◽  
Ultrastructural Changes ◽  
Periodic Acid Schiff ◽  
Falx Cerebri ◽  
Cytoplasmic Staining ◽  
Left Cerebral Hemisphere

A 10-year-old, female spayed Chihuahua dog was presented to the Veterinary Teaching Hospital at the University of Georgia for evaluation of seizures, abnormal mentation, and cervical pain of 2 months duration. On magnetic resonance imaging, there was generalized thickening of the meninges overlying the left cerebral hemisphere and along the falx cerebri. Despite symptomatic treatment, the dog remained neurologically affected. Consequently, the owners elected euthanasia. On gross examination, the meninges covering the left cerebral hemisphere were severely thickened and firmly adhered to the calvaria. On transverse section, the white matter of the left cerebral hemisphere was swollen, enlarged, and extended across the midline with resultant compression of the right cerebral hemisphere. Cytologic evaluation of an impression smear of the thickened meninges showed numerous large, spindloid to polygonal cells with abundant, amphophilic, vacuolated cytoplasm, present either in clusters or in individual cells. Histopathologic evaluation of the meninges revealed a poorly circumscribed and infiltrative, moderately cellular neoplasm, composed of vacuolated, spindloid to polygonal cells with marked anisocytosis and anisokaryosis, arranged in sheets, and occasionally separated by thick bands of connective tissue. Immunohistochemistry for vimentin revealed diffuse cytoplasmic staining of the neoplastic cells. Although the periodic acid–Schiff reaction was negative, ultrastructural findings showed numerous vesicles that were empty or that contained membranous or electron-dense material. Based on gross, microscopic, immunohistochemical, and ultrastructural changes, the meningeal neoplasm was diagnosed as an atypical granular cell tumor.

scholarly journals Granular Cell Tumor of Breast: Rare Tumor Masquerading as Malignancy

2020 ◽  
Vol 42 (1) ◽  
pp. 62-64
Author(s):  
Suzita Hirachan ◽  
Yogendra P Singh ◽  
Anamika Jha ◽  
Usha Manandhar
Keyword(s):  
Granular Cell Tumor ◽  
Periodic Acid ◽  
Granular Cell ◽  
Cell Tumor ◽  
Periodic Acid Schiff ◽  
Granular Eosinophilic Cytoplasm ◽  
Eosinophilic Cytoplasm ◽  
S 100 ◽  
Proper Diagnosis ◽  
The Right

Granular cell tumor (GCT) is a rare soft tissue tumor that arises from the Schwann cells of peripheral nerves. It was first postulated by Abrikossoff in 1926 as Myoblastoma. About 5-15% of these tumors occur in the breast and less than 1% has the potential to be malignant. Here we present a case of 41 years old premenopausal woman with Benign GCT of the right breast, having clinically malignant features. The clinical and radiological features of GCT are similar to malignant lump. However, histology showing presence of sheets of polygonal cells with abundant granular eosinophilic cytoplasm with round nuclei and granules with Periodic acid–Schiff (PAS) positive, diastase resistant and S-100 antigen positive are confirmatory. Treatment of Granular cell tumor is wide local excision. There is apparently no role of chemotherapy and radiotherapy. The presence of GCT in the breast is quite rare and clinically as well as radiologically it may mimic malignancy, however with histopathology and appropriate immunohistochemistry, proper diagnosis can be made.

Granular Cell Variants in a Rat Schwannoma. Evidence of Neurogenic Origin of Granular Cell Tumor (Myoblastoma)

1978 ◽  
Vol 15 (6) ◽  
pp. 725-731 ◽  
Author(s):  
J. J. Berman ◽  
J. M. Rice ◽  
J. Strandberg
Keyword(s):  
Schwann Cells ◽  
Granular Cell Tumor ◽  
Periodic Acid ◽  
Granular Cell ◽  
Cell Tumor ◽  
Granular Cells ◽  
Periodic Acid Schiff ◽  
Pas Reaction ◽  
Granular Cytoplasm ◽  
General Configuration

A large, intraabdominal rat schwannoma had numerous granule-containing cells cytologically identical to cells of granular cell tumor (myoblastoma). The small eosinophilic granules stained positively by the periodic acid-Schiff (PAS) reaction, with intensity not reduced by diastase pretreatment. Granules stained positively with the Tibor Pap silver impregnation for reticulin and by electron microscopy were identical to myoblastoma cell granules. The nuclei of granular cells were morphologically identical to those of the neoplastic Schwann cells. The granular cells were in numerous foci within the tumor, frequently were seen in mitosis, and possessed an extremely variable volume of cytoplasm. They seemed to evolve from neoplastic Schwann cells. Cells with only a narrow perinuclear rim of granular cytoplasm were of the same size and general configuration as adjacent neoplastic Schwann cells, while cells with increasing volumes of granular cytoplasm were increasingly swollen and round. One area of the tumor was composed almost entirely of such large cells and was histologically identical to classic granular cell tumor.

Granular cell tumor of the pituitary stalk

1994 ◽  
Vol 80 (6) ◽  
pp. 1103-1107 ◽  
Author(s):  
Catherine Lafitte ◽  
Bruno Aesch ◽  
Françoise Henry-Lebras ◽  
Franck Fetissof ◽  
Michel Jan
Keyword(s):  
Granular Cell Tumor ◽  
Histopathological Examination ◽  
Granular Cell ◽  
Brain Parenchyma ◽  
Magnetic Resonance Images ◽  
Cell Tumor ◽  
Pituitary Stalk ◽  
Electron Microscopic ◽  
Content Type ◽  
Microscopic Studies

✓ The case is described of a granular cell tumor of the pituitary stalk in a 40-year-old woman with secondary amenorrhea. A computerized tomography scan showed a large contrast-enhancing mass, and T1-weighted magnetic resonance images demonstrated a tumor isointense to the brain parenchyma with nonhomogeneous enhancement after intravenous administration of gadolinium diethylenetriamine penta-acetic acid. Histopathological examination, especially immunocytochemical and electron microscopic studies, showed elements supporting an astrocytic origin for this type of tumor, a hypothesis advanced by many authors but still controversial.

Canine Peripheral Nerve Sheath Tumor with Eosinophilic Cytoplasmic Globules

1998 ◽  
Vol 35 (3) ◽  
pp. 223-226 ◽  
Author(s):  
M. Kuwamura ◽  
J. Yamate ◽  
T. Kotani ◽  
T. Takeuchi ◽  
S. Sakuma
Keyword(s):  
Peripheral Nerve ◽  
Tumor Cells ◽  
Periodic Acid ◽  
Neuron Specific Enolase ◽  
Granular Cell ◽  
Nerve Sheath Tumor ◽  
Periodic Acid Schiff ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Spindle Cell Proliferation

A 13-year-old male Shetland Sheepdog had a subcutaneous tumor in the left brachium. The tumor was removed and recurred several times at 5, 13, 16, 22, and 31 months after the initial presentation. Histologically, the removed nodules from the fourth resection were composed of neoplastic proliferation of round to fusiform cells, which possessed eosinophilic globules in their cytoplasm. The globules were periodic acid–Schiff positive and diastase resistant. Positive reactions for acid phosphatase were observed in the cytoplasm of the tumor cells. Ultrastructurally, these globules consisted of membrane-bound, dense structures containing dense granules, lucent vacuoles, and homogeneous materials. The recurrent tumors removed at the fifth resection consisted of spindle cell proliferation arranged in interlacing fascicles with wavy nuclei and containing a small number of cells with cytoplasmic globules. The tumor cells were immunoreactive to vimentin, S-100 protein, myelin basic protein, and neuron-specific enolase. The tumor was diagnosed as a peripheral nerve sheath tumor with eosinophilic cytoplasmic globules. These findings are unique for the histogenesis of granular cell tumors.

scholarly journals Multifocal Abrikossoff's granular cell tumor of the oesophagus: Case report

2008 ◽  
Vol 136 (9-10) ◽  
pp. 533-537 ◽  
Author(s):  
Tomislav Randjelovic ◽  
Zorica Stojsic ◽  
Jasna Gacic ◽  
Darko Babic ◽  
Miodrag Stojiljkovic ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Granular Cell Tumor ◽  
Pathological Finding ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Posterior Mediastinum ◽  
Cell Tumor ◽  
Ki 67 ◽  
Luminal Narrowing ◽  
Operative Specimen

INTRODUCTION Granular cell tumors, relatively uncommon soft tissue tumors, have been a matter of debate among pathologists regarding histogenesis for a long time. Less common locations are in the aerodigestive tract including the oesophagus. CASE OUTLINE We have recently treated a rare case, a 37-year old male, who was admitted due to dysphagia and a painful swallow with occasional pharyngo-nasal regurgitation followed with a mild loss of weight. Standard clinical examination including X-ray chest, ECG and laboratory tests did not show pathological findings. Barium contrast oesophagography demonstrated multiple ovoid defects in the wall of the oesophagus. CT scan of the chest confirmed luminal narrowing owing to the tumor of the upper oesophagus. Upper endoscopy showed unusual multifocal nodular lesions alongside the oesophageal axis covered by smooth mucosa. A primary biopsy specimen taken from the largest nodules confirmed an unusual pathological finding of the granular cell tumor. Subtotal, transpleural oesophagectomy was performed and reconstruction was derived by long colon segment interposition through the posterior mediastinum. The postoperative course was uneventful. The operative specimen consisted of four ovoid tumors alongside the oesophagus (the greatest diameter 0.5-1.8, average 1.25). All verified tumors histologicaly consisted of a spindle-shaped or polygonal cells containing small and large eosinophilic granules and central nuclei. Most tumor cells showed strongly positive immunohistochemical staining for S-100 protein. These tumor cells were partially positive for p-53 and Ki-67. No lymph node metastases were detected histologically. CONCLUSION Multifocal granular cell tumor of the oesophagus is an unusual finding with low incidence, and rarely caused symptoms. Pathological features and multiplicity of such tumors emphasized malignant predisposition requiring surgical resection of the oesophagus.

An Unusual Case of Generalized Ceroid-Lipofuscinosis in a Cynomolgus Monkey

1984 ◽  
Vol 21 (1) ◽  
pp. 46-50 ◽  
Author(s):  
V. Jasty ◽  
R. L. Kowalski ◽  
E. H. Fonseca ◽  
M. C. Porter ◽  
G. R. Clemens ◽  
...  
Keyword(s):  
Cynomolgus Monkey ◽  
Periodic Acid ◽  
Electron Microscopic ◽  
Periodic Acid Schiff ◽  
Ceroid Lipofuscinosis ◽  
Age Related ◽  
Lipofuscin Pigment ◽  
Microscopic Studies ◽  
Membrane Bound ◽  
Hematoxylin And Eosin

Histologic, histochemical, and electron microscopic studies of generalized ceroid-lipofuscinosis in a cynomolgus monkey are presented. Histologically, a wide variety of tissue cells contained numerous bright eosinophilic intracytoplasmic granules that varied in size from 0.5 μm to 4.0 μm in diameter. Histochemically, the granules gave a weakly positive reaction with periodic acid-Schiff and for lipids. They were weakly acid fast and capable of emitting autofluorescence. Ultrastructurally, the granules were single unit membrane-bound, and contained dense osmiophilic material with frequent concentric or fingerprint-type lamellar formation. The granules were different than hemofuscin, iron, and bilirubin. Tinctorially the granules were unique—they were bright red with hematoxylin and eosin and, thus, differed from typical age-related lipofuscin pigment.

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