Granular cell tumor of the pituitary stalk

1994 ◽  
Vol 80 (6) ◽  
pp. 1103-1107 ◽  
Author(s):  
Catherine Lafitte ◽  
Bruno Aesch ◽  
Françoise Henry-Lebras ◽  
Franck Fetissof ◽  
Michel Jan
Keyword(s):  
Granular Cell Tumor ◽  
Histopathological Examination ◽  
Granular Cell ◽  
Brain Parenchyma ◽  
Magnetic Resonance Images ◽  
Cell Tumor ◽  
Pituitary Stalk ◽  
Electron Microscopic ◽  
Content Type ◽  
Microscopic Studies

✓ The case is described of a granular cell tumor of the pituitary stalk in a 40-year-old woman with secondary amenorrhea. A computerized tomography scan showed a large contrast-enhancing mass, and T1-weighted magnetic resonance images demonstrated a tumor isointense to the brain parenchyma with nonhomogeneous enhancement after intravenous administration of gadolinium diethylenetriamine penta-acetic acid. Histopathological examination, especially immunocytochemical and electron microscopic studies, showed elements supporting an astrocytic origin for this type of tumor, a hypothesis advanced by many authors but still controversial.

Giant Granular Cell Tumor of the Suprasellar Area; Immunocytochemical and Electron Microscopic Studies

Neurosurgery ◽  
1984 ◽  
Vol 15 (2) ◽  
pp. 246-251 ◽  
Author(s):  
Boleslaw H. Liwnicz ◽  
Boleslaw H. Liwnicz ◽  
Regina G. Liwnicz ◽  
Stephen J. Huff ◽  
Bert H. McBride ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Granular Cell Tumor ◽  
Periodic Acid ◽  
Granular Cell ◽  
Cell Tumor ◽  
Electron Microscopic ◽  
Periodic Acid Schiff ◽  
Computed Tomographic ◽  
Suprasellar Region ◽  
Microscopic Studies

Abstract We describe a case of a granular cell tumor (GCT) of the suprasellar region with an 11-year history in a 26-year-old woman. The computed tomographic scan showed a midline, contrast-enhancing, noncalcified mass. The biopsy was diagnosed as GCT. The tumor was treated with radiation therapy. At necropsy, a large, homogeneous GCT surrounded by gliosis was found. The tumor cells were filled with granules positive for periodic acid-Schiff, diastase-resistant. The cells did not contain glial fibrillary acidic protein or S-100 protein. Electron microscopy showed tumor cells filled with innumerable lysosomal structures. No intermediate filament was found within the cytoplasm. The tumor cells were not surrounded by a basement membrane. Based on this study and on our review of the literature, the suggestion that GCT has a multicellular origin is upheld.

scholarly journals Infrascapular granular cell tumor: an unusual entity

2017 ◽  
Vol 4 (1) ◽  
pp. 293
Author(s):  
Sabina Khan ◽  
Sujata Jetley
Keyword(s):  
Soft Tissue ◽  
Granular Cell Tumor ◽  
Malignant Tumors ◽  
Histopathological Examination ◽  
Granular Cell ◽  
Cell Tumor ◽  
Cutaneous Lesions ◽  
Clinical Appearance ◽  
Common Location ◽  
Schwannian Origin

Granular cell tumor (GCT) is an uncommon soft tissue tumor of schwannian origin frequent among women and blacks between the second and sixth decades of life. The common location of GCT is the oral cavity, but it can also occur at other sites. Cutaneous lesions constitute about 30% of cases and are characterized by a gradually developing nodular lesion. Due to their subtle clinical appearance and symptomatology, GCTs are often misdiagnosed. We report a case of subcutaneous GCT in the infrascapular region in a 40 year old female which mimicked granular cell dermatofibroma on histopathology. Although a rare entity, Granular cell tumor should be considered in the differential diagnosis of the subcutaneous soft tissue tumours and require histopathological examination along with immunohistochemistry to confirm the diagnosis and differentiate them from other benign and malignant tumors showing granular cell change.

scholarly journals Granular Cell Tumor in the Pituitary Stalk: A Case Report

2015 ◽  
Vol 3 (1) ◽  
pp. 60 ◽  
Author(s):  
Soo Jeong Park ◽  
Youn Hyuk Chang ◽  
Na-Rae Yang ◽  
Eui Kyo Seo
Keyword(s):  
Case Report ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Pituitary Stalk

scholarly journals Malignant granular cell tumor of the arm – case report

2021 ◽  
Vol 4 (1) ◽  
pp. 3-8
Author(s):  
Mihai Mehedinţu ◽  
Răzvan Danciu ◽  
Anca I. Toma ◽  
Corina Ştefan ◽  
Cristian R. Jecan
Keyword(s):  
Granular Cell Tumor ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Granular Cell ◽  
Surgical Excision ◽  
Female Gender ◽  
Cell Tumor ◽  
Malignant Granular Cell Tumor ◽  
Tissue Cancer

Abstract Granular cell tumor (GCT) is a rare form of soft tissue cancer that is usually benign. Its malignant evolution is encountered in less than 2% of cases, having a more rapid and unfavorable evolution. Clinical presentation betraying malignant features could be increased tumor size, rapid growth, deep localization, and female gender. This paper presents the case of a 52-year-old patient with a hard, rapidly evolving tumor in the left arm. The diagnosis of granular cell tumor was made based on histopathological examination using the Fanburg and Smith criteria to differentiate the formation as malignant, but with certainty this was subsequently confirmed by the existence of a metastasis. Surgical excision was performed and the evolution was favorable. Evolution and treatment differ depending on the benign or malignant form, but surgical treatment with wide local excision is recommended. This may be followed by chemotherapy or radiotherapy, and follow-up of patients for the rest of their lives is mandatory.

Acromegaly associated with a granular cell tumor of the neurohypophysis: a clinical and histological study

2000 ◽  
Vol 93 (1) ◽  
pp. 121-126 ◽  
Author(s):  
Marco Losa ◽  
Wolfgang Saeger ◽  
Pietro Mortini ◽  
Claudio Pandolfi ◽  
Maria Rosa Terreni ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Granular Cell Tumor ◽  
Sella Turcica ◽  
Granular Cell ◽  
Cell Tumor ◽  
Oral Glucose ◽  
Content Type ◽  
Releasing Hormone ◽  
Operative Specimen ◽  
Fine Print

✓ Acromegaly is usually caused by a growth hormone (GH)-secreting pituitary adenoma, and hypersecretion of GH-releasing hormone (GHRH) from a hypothalamic or neuroendocrine tumor accounts for other cases. The authors report on the unusual association of acromegaly with a granular cell tumor of the neurohypophysis.A 42-year-old woman with a 10-year history of acral enlargement, headache, and menstrual abnormalities was referred to our department for a suspected GH-secreting pituitary adenoma. The patient's basal GH levels were mildly elevated at 4.8 µg/L, were not suppressed in response to an oral glucose tolerance test, and increased paradoxically after administration of thyrotropin-releasing hormone. The patient's insulin-like growth factor—1 (IGF-1) level was elevated at 462 µg/L, whereas a magnetic resonance image of the sella turcica revealed an intra- and suprasellar lesion that was compatible with a diagnosis of pituitary adenoma. A transsphenoidal approach to remove the lesion, which was mainly suprasellar, was successful during a second operative attempt, resulting in the clinical and biochemical regression of the patient's acromegaly. Four months postoperatively, the patient's basal GH level was 0.9 µg/L and her IGF-1 level was 140 µg/L. Histological analysis of the operative specimen demonstrated a granular cell tumor of the neurohypophysis, which when stained proved negative for pituitary hormones and GHRH.This case represents the first reported association between a granular cell tumor of the neurohypophysis and acromegaly. Granular cell tumor of the neurohypophysis could be added to the restricted list of neoplastic causes of acromegaly secondary to hypersecretion of a GH-releasing substance.

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