Cisternal Drainage after Early Operation of Ruptured Intracranial Aneurysm

Neurosurgery ◽  
1987 ◽  
Vol 20 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Yasuto Kawakami ◽  
Yutaka Shimamura
Keyword(s):  
Intracranial Aneurysm ◽  
Anterior Part ◽  
Signs And Symptoms ◽  
Early Operation ◽  
Neurological Condition ◽  
Social Lives ◽  
Symptomatic Vasospasm ◽  
Ruptured Intracranial Aneurysm ◽  
Cisternal Drainage ◽  
Subarachnoid Blood

Abstract The authors reviewed 22 cases of intracranial aneurysm of the anterior part of the circle of Willis. All patients presented with the signs and symptoms of subarachnoid hemorrhage (SAH) and were in good neurological condition on admission. In all cases, early operation was performed to obliterate aneurysm. Subarachnoid blood clots were extensively removed and cisternal drainage was done. With topical application of povidone-iodine and intravenous administration of antibiotics, cisternal drainage continued for 14 days or more after the onset of SAH in 21 cases. Five patients developed symptomatic vasospasm, which was treated with hypervolemia and hypertension, and three received shunts later for chronic hydrocephalus. The overall result demonstrated that 21 patients were independent and had returned to their previous social lives. Therefore, it was strongly recommended that patients is good neurological condition after SAH secondary to ruptured intracranial aneurysm be treated with early operation, removal of subarachnoid clots, and long term application of cisternal drainage.

scholarly journals Effect of Continuous Cisternal Drainage for Symptomatic Vasospasm after Early Operation for Intracranial Aneurysm

1991 ◽  
Vol 19 (2) ◽  
pp. 274-277
Author(s):  
Tsutomu YAGISHITA ◽  
Hideaki NUKUI ◽  
Masami KANEKO ◽  
Shigeru MITSUKA ◽  
Kazuyuki NISHIGAYA ◽  
...  
Keyword(s):  
Intracranial Aneurysm ◽  
Early Operation ◽  
Symptomatic Vasospasm ◽  
Cisternal Drainage

scholarly journals Factors associated with outcomes in ruptured aneurysmal patients: Clinical Study of 80 Patients

2015 ◽  
Vol 22 (1) ◽  
pp. 104-111
Author(s):  
Gobran Taha Ahmed Alfotih ◽  
Fang-Cheng Li ◽  
Xin-Ke Xu ◽  
Shang-Yi Zhang
Keyword(s):  
Intracranial Aneurysm ◽  
Intracranial Aneurysms ◽  
Surgical Intervention ◽  
Optimal Timing ◽  
Strong Impact ◽  
Neurological Condition ◽  
Ruptured Intracranial Aneurysm ◽  
Outcome Scores ◽  
Age Range ◽  
Ruptured Intracranial Aneurysms

Abstract Background: Due to insufficient data in the literature, the optimal timing for surgical intervention for ruptured intracranial aneurysms is still controversial. Some practitioners advocate early surgery, but others not. It is important to identify other factors that can be used to predict poor prognosis in ruptured intracranial aneurysm patients. Objective: To determine the influence of timing of clipping surgery, and other factors on the outcomes of ruptured intracranial aneurysms in Hunt & Hess I~III grade patients. Method: We have performed a retrospective study involving 80 patients who were surgically treated for ruptured intracranial aneurysm between 2007 and 2012. The patient population consisted of 50(62.5%) females and 30(37.5%) males, with an age range of 12 to 75 years old, mean age 52.33 ± 10.63 years. We measured association between the Glasgow Outcome Scores and Sex, timing of clipping surgery, aneurysm location and pre-operative patient's neurological condition using famous Hunt and Hess grade system. Results: We did not find any correlation between the outcomes of ruptured intracranial aneurysm patients and timing (early, intermediate, late stage) of clipping, sex, aneurysm location. Whereas there is a significant correlation between patients outcomes and pre-operative patient neurological condition (Hunt & Hess grade). Conclusion: Timing of Surgery (early, intermediate, late) does not affect outcomes in low Hunt and Hess grade patients I~III. Whereas neurological condition (Hunt & Hess) has strong impact on postoperative outcomes. Others factors like sex, Age, Aneurysm location have no effect on outcomes in ruptured intracranial aneurysms.

scholarly journals The Efficacy of Decompressive Craniotomy as an Adjunctive Therapy for Early Operation of Ruptured Intracranial Aneurysm

1989 ◽  
Vol 17 (3) ◽  
pp. 280-284
Author(s):  
Tokio MATSUNAGA ◽  
Seisho ABIKO ◽  
Tetsuo YAMASHITA ◽  
Tetsuji ORITA ◽  
Yujiro SHIROYAMA ◽  
...  
Keyword(s):  
Intracranial Aneurysm ◽  
Adjunctive Therapy ◽  
Early Operation ◽  
Decompressive Craniotomy ◽  
Ruptured Intracranial Aneurysm

scholarly journals Identification of upregulated NF-κB inhibitor alpha and IRAK3 targeting lncRNA following intracranial aneurysm rupture-induced subarachnoid hemorrhage

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wei Leng ◽  
Dan Fan ◽  
Zhong Ren ◽  
Qiaoying Li
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Intracranial Aneurysm ◽  
Signaling Pathway ◽  
Aneurysm Rupture ◽  
Cytokine Receptor ◽  
Gene Set Enrichment Analysis ◽  
Receptor Interaction ◽  
Regulatory Pathways ◽  
Ruptured Intracranial Aneurysm ◽  
Neurotrophin Signaling

Abstract Background This study was performed to identify genes and lncRNAs involved in the pathogenesis of subarachnoid hemorrhage (SAH) from ruptured intracranial aneurysm (RIA). Methods Microarray GSE36791 was downloaded from Gene Expression Omnibus (GEO) database followed by the identification of significantly different expressed RNAs (DERs, including lncRNA and mRNA) between patients with SAH and healthy individuals. Then, the functional analyses of DEmRNAs were conducted and weighted gene co-expression network analysis (WGCNA) was also performed to extract the modules associated with SAH. Following, the lncRNA-mRNA co-expression network was constructed and the gene set enrichment analysis (GSEA) was performed to screen key RNA biomarkers involved in the pathogenesis of SAH from RIA. We also verified the results in a bigger dataset GSE7337. Results Totally, 561 DERs, including 25 DElncRNAs and 536 DEmRNAs, were identified. Functional analysis revealed that the DEmRNAs were mainly associated with immune response-associated GO-BP terms and KEGG pathways. Moreover, there were 6 modules significantly positive-correlated with SAH. The lncRNA-mRNA co-expression network contained 2 lncRNAs (LINC00265 and LINC00937) and 169 mRNAs. The GSEA analysis showed that these two lncRNAs were associated with three pathways (cytokine-cytokine receptor interaction, neurotrophin signaling pathway, and apoptosis). Additionally, IRAK3 and NFKBIA involved in the neurotrophin signaling pathway and apoptosis while IL1R2, IL18RAP and IL18R1 was associated with cytokine-cytokine receptor interaction pathway. The expression levels of these genes have the same trend in GSE36791 and GSE7337. Conclusion LINC00265 and LINC00937 may be implicated with the pathogenesis of SAH from RIA. They were involved in three important regulatory pathways. 5 mRNAs played important roles in the three pathways.

The safety of intraoperative lumbar subarachnoid drainage for acutely ruptured intracranial aneurysm: Technical note

1997 ◽  
Vol 48 (4) ◽  
pp. 338-344 ◽  
Author(s):  
E.Sander Connolly ◽  
Abraham A. Kader ◽  
Vincent I. Frazzini ◽  
Christopher J. Winfree ◽  
Robert A. Solomon
Keyword(s):  
Intracranial Aneurysm ◽  
Technical Note ◽  
Ruptured Intracranial Aneurysm

Abstract WMP30: Circulating MicroRNAs as Potential Novel Diagnostic Biomarkers for Ruptured Intracranial Aneurysm

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Zhang Xin ◽  
Liu L Ping
Keyword(s):  
Intracranial Aneurysm ◽  
Target Genes ◽  
Bioinformatic Analysis ◽  
Aneurysm Rupture ◽  
Pathological Process ◽  
Differentially Expressed ◽  
Diagnostic Biomarkers ◽  
Ruptured Intracranial Aneurysm ◽  
Novel Biomarkers ◽  
Aneurysm Development

Background and Objective: MicroRNAs have been shown to regulate in several pathological process of intracranial aneurysms. The study aimed to estimate whether miRNAs have the potential to become novel biomarkers for intracranial aneurysm rupture. Materials and methods Forty-five ruptured intracranial aneurysm patients were enrolled according to the inclusion criteria, meanwhile thirty-five healthy individuals were recruited in this study. Differentially expressed plasma miRNA profiles were screened in five pairs of patients and controls in microarray study. Then validation was performed in the rest of the objects using quantitative real-time PCR assays. Results: Fourteen significantly changed miRNAs were screened out from patients with aneurysms compared with healthy controls. More than three thousand target genes related to these disregulated miRNAs were found and bioinformatic analysis revealed that these miRNA were involved in intracranial aneurysm development and rupture. Ultimately four miRNAs from screening profile and one supplementary miRNA were demonstrated to be significantly altered. Conclusion: We demonstrated that several miRNAs were differentially expressed among ruptured aneurysm patients and healthy participants, and plasma miRNAs may be novel diagnostic biomarkers in intracranial aneurysm rupture.

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