Prolactin-Secreting Adenomas: Surgical Results and Long-Term Follow-up

ABSTRACT Transsphenoidal surgery is an efficacious treatment for patients with prolactin (PRL)-secreting adenomas, even if disrupted pituitary-hypothalamic relationships may persist and/or a recurrence of the PRL-secreting tumor can occur. In this paper, we analyze the long-term follow-up of 119 consecutively treated women who underwent transsphenoidal microsurgery for PRL-secreting adenomas. Apparent total removal of the tumor was achieved in 98 patients who had enclosed tumors (58 with Grade-I tumors and 40 with Grade II). In the remaining patients, the removal was considered partial. Persistent normal basal PRL levels were achieved in 61 patients who had apparent total removal of the adenoma (44 with Grade I tumors and 17 with Grade II). Of the remaining 37 patients in whom surgical removal of the adenomatous tissue was thought to be total, 30 had persistent nonevolutive, high PRL levels ranging from 21 to 196 ng/ml, without clinical and radiological signs of tumor regrowth, and 7 with PRL levels ranging from 56 to 560 ng/ml had a recurrence of the PRL-secreting tumor. These data seem to indicate that a slightly elevated postsurgical PRL value does not imply that tumoral tissue is still present. Nontumoral conditions (i.e., a secondary empty sella) could induce functional hyperprolactinemia.

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Prolactin-Secreting Adenomas - Surgical Results

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100030067 ◽

1990 ◽

Vol 17 (1) ◽

pp. 67-70 ◽

Cited By ~ 6

Author(s):

Giulio Maira ◽

Carmelo Anile ◽

Laura De Marinis ◽

Antonino Barbarino

Keyword(s):

Tumor Recurrence ◽

Surgical Results ◽

Total Removal ◽

Microsurgical Treatment ◽

Long Term Follow Up ◽

Grade Ii ◽

Tumor Regrowth

ABSTRACT:The long-term follow-up of the transsphenoidal microsurgical treatment in 119 consecutively operated women with a PRL-secreting adenoma is presented. An apparent total removal of the tumor was achieved in 98 cases with an enclosed tumor (58 grade I and 40 grade II). In the remaining cases the removal was considered partial. The achievement of persistent normal PRL basal levels was verified in 61 patients (44 grade I and 17 grade II) who had an apparent total removal of the adenoma. In the 37 remaining patients who were thought at surgery to have had total removal we have distinguished two groups: 30 patients showed a “relapse” or “persistence” of PRL levels below 200 ng/ml without clinical and radiological signs of tumor regrowth, and 7 patients with a PRL level higher than 200 ng/ml who had evidence of PRL-secreting tumor recurrence.

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Tu1889 A Long-Term Follow-Up of Patients With Recurring Sporadic Polyps: Is There a Benefit From Mutation Testing of Adenomatous Tissue?

Gastroenterology ◽

10.1016/s0016-5085(14)63144-9 ◽

2014 ◽

Vol 146 (5) ◽

pp. S-864-S-865

Author(s):

Stepan Suchanek ◽

Barbora Belsanova ◽

Lucie Benesova ◽

Petra Minarikova ◽

Inna Tuckova ◽

...

Keyword(s):

Mutation Testing ◽

Long Term Follow Up ◽

Adenomatous Tissue

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Long-term seizure outcome following surgery for dysembryoplastic neuroepithelial tumor

Journal of Neurosurgery ◽

10.3171/jns.2006.104.1.62 ◽

2006 ◽

Vol 104 (1) ◽

pp. 62-69 ◽

Cited By ~ 59

Author(s):

Chow Huat Chan ◽

Richard G. Bittar ◽

Gavin A. Davis ◽

Renate M. Kalnins ◽

Gavin C. A. Fabinyi

Keyword(s):

Outcome Data ◽

Temporal Lobectomy ◽

Class I ◽

Surgical Removal ◽

Dysembryoplastic Neuroepithelial Tumor ◽

Seizure Outcome ◽

Short Term ◽

Long Term Follow Up

Object Resection of dysembryoplastic neuroepithelial tumor (DNET) is thought to result in favorable seizure outcome, but long-term follow-up data are scarce. The authors present a review of 18 patients who underwent surgical removal of a DNET: 12 via temporal lobectomy and six via lesionectomy. Methods The mean long-term follow up was 10.8 years (median 10.4 years, range 7.8 to 14.8 years), and results obtained during this time period were compared with previously reported short-term (mean 2.7 years) seizure outcome data. In the current study, 66.7% patients had an Engel Class I outcome and 55.6% had an Engel Class IA outcome compared with 77.8% and 55.6%, respectively. Temporal lobectomy (Engel Class I, 83.3%; Engel Class IA, 66.7%) led to a better seizure outcome than lesionectomy (Engel Classes I and IA, 33.3%). Two patients (11.1%) required repeated operation and both had an incomplete lesionectomy initially. Conclusions Results indicated that complete resection of a DNET leads to a favorable seizure outcome, with epilepsy cure in those who had experienced early postoperative seizure relief. Long-term seizure outcome after surgery is predictable based on the result of short-term follow up.

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Long-term follow-up after surgical removal of thymolipoma

Polish Journal of Cardio-Thoracic Surgery ◽

10.5114/kitp.2019.91392 ◽

2019 ◽

Vol 16 (4) ◽

pp. 206-208

Author(s):

Mahnaz Amini ◽

Seyed Masuom ◽

Asieh Fattahi

Keyword(s):

Surgical Removal ◽

Long Term Follow Up

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Traumatic Fracture of the Medial Coronoid Process in Two Dogs

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.1055/s-0038-1633092 ◽

1994 ◽

Vol 07 (04) ◽

pp. 173-176 ◽

Cited By ~ 6

Author(s):

J. C. Yovich ◽

R. A. Read

Keyword(s):

Coronoid Process ◽

Surgical Removal ◽

Elbow Trauma ◽

Traumatic Fracture ◽

Elbow Movement ◽

Long Term Follow Up ◽

Elbow Function ◽

One Year

SummaryAcute traumatic fracture of the me-dial coronoid process occurred in two adult dogs. The fracture was the sole injury in one dog, but was associated with further elbow trauma in the other. Surgical removal of the fractured portion of medial coronoid process resulted in a rapid return to normal elbow function which was sustained on long-term follow-up. Radiographs showed some osteophyte formation within the elbow joints at one year postoperatively. Two years later, repeat radiography of the elbow of one of the dogs did not show any further osteophyte production. In contrast, the surgical removal of fragmented coronoid processes frequently results in continuing lameness, reduced range of elbow movement and progressive osteoarthritis.Removal of a traumatically fractured portion of the medial coronoid process in two adult dogs resulted in a rapid return to soundness. Elbow function in both dogs remained normal on long-term follow-up.

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Long-term follow-up after surgical removal of meningioma of the inner third of the sphenoidal wing: outcome determinants and different strategies

Neurosurgical Review ◽

10.1007/s10143-018-1018-1 ◽

2018 ◽

Vol 43 (1) ◽

pp. 109-117 ◽

Cited By ~ 3

Author(s):

Andrea Talacchi ◽

Aurel Hasanbelliu ◽

Alberto D’Amico ◽

Nicolò Regge Gianas ◽

Francesca Locatelli ◽

...

Keyword(s):

Surgical Removal ◽

Long Term Follow Up

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Oligodendroglioma arising in the glial component of ovarian teratomas: a series of six cases and review of literature

Journal of Clinical Pathology ◽

10.1136/jclinpath-2012-200714 ◽

2012 ◽

Vol 65 (7) ◽

pp. 631-634 ◽

Cited By ~ 11

Author(s):

Nasir Ud Din ◽

Aisha Memon ◽

Kanwal Aftab ◽

Zubair Ahmad ◽

Rashida Ahmed ◽

...

Keyword(s):

Review Of Literature ◽

Ki 67 ◽

Who Grade ◽

Long Term Follow Up ◽

Grade Ii ◽

The Right ◽

Rule Out ◽

Ovarian Teratomas

AimsTo report the exceedingly rare occurrence of oligodendroglioma in the glial component of ovarian teratomas.MethodsSix cases of oligodendrogliomas arising in the glial component of ovarian teratomas were studied and the literature was reviewed. Immunohistochemistry was performed by the Flex technique.ResultsThe ages of the patients ranged from 12 to 28 years (mean 21 years). Four tumours were located in the right and one in the left ovary. The size of the ovarian cysts ranged from 7 cm to 29 cm (mean 19.6 cm). Four cases arose in immature and two cases in mature teratomas. In all cases, oligodendroglioma was WHO grade II. On immunohistochemistry, glial fibrillary acidic protein stain was positive in all cases. The Mib 1 (Ki 67) proliferative index was low and the tumour cells were negative for synaptophysin. Follow-up was available in five patients and ranged from 1 to 42 months. Two patients died of disease after 1 and 36 months of diagnosis, respectively. In both these cases oligodendroglioma arose in an immature teratoma. The remaining three patients are alive with a follow-up of 4–42 months.ConclusionsOligodendroglioma arising in the glial component of ovarian teratomas is exceedingly rare. Ovarian teratomas should be extensively sampled and carefully evaluated to rule out the possibility of a glial tumour. This is the single and largest series of oligodendrogliomas arising in ovarian teratomas. The prognosis is good for oligodendrogliomas arising in mature teratomas compared with those arising in immature teratomas, although long-term follow-up is needed to determine the exact behaviour.

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Long-Term Follow-Up of Patients with Malignant Pedunculated Colon Polyps after Colonoscopic Polypectomy

Canadian Journal of Gastroenterology ◽

10.1155/2013/380389 ◽

2013 ◽

Vol 27 (1) ◽

pp. 20-24 ◽

Cited By ~ 13

Author(s):

Hugh James Freeman

Keyword(s):

Colon Cancer ◽

Early Stage ◽

Surgical Removal ◽

Neoplastic Disease ◽

Colon Polyps ◽

Increased Risk ◽

Long Term Follow Up ◽

Malignant Polyps

BACKGROUND: Previously published studies have suggested that patients with resected colon cancer have an increased risk for early metachronous colon cancer. Current screening guidelines recommend intense surveillance by colonoscopy for the initial five years after the initial colon cancer has been resected. Information regarding endoscopically removed malignant polyps is limited.METHODS: In the present study, 25 consecutive patients (14 male, 11 female) with malignant pedunculated colon polyps treated with snare cautery polypectomy were followed for more than one decade up to 20 years. Five patients required an additional resection to ensure that removal of the original cancer was complete. Annual colonoscopies were planned for five years. If an adenoma was detected in the fifth year, colonoscopy was performed annually until no adenomas were detected. Otherwise, colonoscopy was planned every three years after five years.RESULTS: In the present study, there was no mortality from colon cancer and no patient developed either recurrent colon cancer or an early metachronous colon cancer during the initial five-year period of surveillance. Two patients (one male, one female) ultimately developed late cecal cancers almost one decade after the original colon cancers were resected. One had an early stage cancer that was resected, while the other had an infiltrating mucinous carcinoma complicating a small tubulovillous adenoma with extension to a single lymph node. After surgical removal and adjuvant chemotherapy, no further neoplastic disease has been detected.CONCLUSIONS: Overall, patients with malignant pedunculated polyps do extremely well if appropriately managed at the time of the initial polypectomy. Short-term outcomes after removal of a malignant polyp(s) appear to be similar to those with a nonmalignant polyp. However, late metachronous colon cancer may still occur. Long-term follow-up should be considered in each patient, assuming reasonable life expectancy, because risk of additional adenomas and metachronous colon cancer persists even after the initial five years of currently recommended surveillance. Patients with resected malignant polyps may represent a special patient subgroup that requires surveillance for more extended periods than current guidelines have recommended.

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Benign Chondroblastoma of The Temporal Bone

Otolaryngology ◽

10.1177/019459987908700213 ◽

1979 ◽

Vol 87 (2) ◽

pp. 229-236 ◽

Cited By ~ 22

Author(s):

Stephen G. Harner ◽

D. Thane R. Cody ◽

David C. Dahlin

Keyword(s):

Temporal Bone ◽

Giant Cells ◽

Surgical Removal ◽

Preoperative Irradiation ◽

Rare Tumor ◽

Pathologic Examination ◽

Ear Canal ◽

Long Term Follow Up

Benign chondroblastoma is a rare tumor in the temporal bone. It occurs preponderantly in middle-aged men as a mass in the posterosuperior region of the ear canal and is accompanied by hearing loss. On pathologic examination, giant cells and focal regions of chondroid differentiation are noted. After the extent of the tumor has been determined, the treatment is surgical removal. Preoperative irradiation may be helpful. Long-term follow-up is essential.

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