scholarly journals Autologous Adipose-derived Stem Cells and Fibrin Glue Used to Treat Widespread Traumatic Calvarial Defects

Skull Base ◽  
2005 ◽  
Vol 15 (S 2) ◽  
Author(s):  
Stefan Lendeckel ◽  
A. Jödicke ◽  
P. Christophis ◽  
K. Heidinger ◽  
H.-P. Howaldt

2018 ◽  
Vol 34 (6) ◽  
pp. 413-420 ◽  
Author(s):  
Davood Mehrabani ◽  
Azizollah Khodakaram-Tafti ◽  
Hanieh Shaterzadeh-Yazdi ◽  
Barbad Zamiri ◽  
Mahsa Omidi

2006 ◽  
Vol 56 (5) ◽  
pp. 543-548 ◽  
Author(s):  
Jason R. Dudas ◽  
Kacey G. Marra ◽  
Gregory M. Cooper ◽  
Virginia M. Penascino ◽  
Mark P. Mooney ◽  
...  

2015 ◽  
Vol 21 (13-14) ◽  
pp. 2053-2065 ◽  
Author(s):  
Jiabing Fan ◽  
Choong Sung Im ◽  
Zhong-Kai Cui ◽  
Mian Guo ◽  
Olga Bezouglaia ◽  
...  

Neurosurgery ◽  
2011 ◽  
Vol 68 (6) ◽  
pp. 1535-1540 ◽  
Author(s):  
Tuomo Thesleff ◽  
Kai Lehtimäki ◽  
Tero Niskakangas ◽  
Bettina Mannerström ◽  
Susanna Miettinen ◽  
...  

Abstract BACKGROUND: There is no optimal method for reconstruction of large calvarial defects. Because of the limitations of autologous bone grafts and alloplastic materials, new methods for performing cranioplasties are needed. OBJECTIVE: To create autologous bone to repair cranial defects. METHODS: We performed a cranioplasty procedure with this new method in 4 patients who had large calvarial defects of different etiologies. We used autologous adipose-derived stem cells seeded in beta-tricalcium phosphate granules. For 2 patients, we used a bilaminate technique with resorbable mesh. RESULTS: During follow-up, there were no clinically relevant postoperative complications. The computed tomography scans revealed satisfactory outcome in ossification, and in the clinical examinations, the outcomes were good. The cranioplasty was measured in Hounsfield units from each computed tomography scan. The Hounsfield units increased gradually to equal the value of bone. CONCLUSION: The combination of scaffold material such as beta-tricalcium phosphate and autologous adipose-derived stem cells constitutes a promising model for reconstruction of human large cranial defects. The success of these clinical cases paves way for further studies and clinical applications to turn this method into a reliable treatment regimen.


2004 ◽  
Vol 32 (6) ◽  
pp. 370-373 ◽  
Author(s):  
Stefan Lendeckel ◽  
Andreas Jödicke ◽  
Petros Christophis ◽  
Kathrin Heidinger ◽  
Jan Wolff ◽  
...  

2020 ◽  
Vol 15 (4) ◽  
pp. 1535-1549
Author(s):  
Arturas Stumbras ◽  
Povilas Kuliesius ◽  
Adas Darinskas ◽  
Ricardas Kubilius ◽  
Vilma Zigmantaite ◽  
...  

Aim: The aim of this study was to evaluate the osteogenic potential of adipose-derived stem cells (ADSCs) and to assess the influence of plasma rich in growth factors (PRGF) on bone regeneration using ADSCs. Materials & methods: Bone defects were randomly allocated to the five treatment modalities: spontaneous healing, natural bovine bone mineral (BBM), BBM loaded with PRGF, BBM loaded with ADSCs and BBM loaded with a combination of ADSCs and PRGF. Results: The PRGF significantly enhanced the biomaterial-to-bone contact. Defects treated with ADSCs and PRGF or a combination of both showed the greatest bone regeneration. Conclusion: Combining PRGF and ADSCs boosts the bone graft regenerative potential at the earliest period of healing.


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