The Association Between Symptomatic Delayed Cerebral Infarction and Serum Adhesion Molecules in Aneurysmal Subarachnoid Hemorrhage

Neurosurgery ◽  
2011 ◽  
Vol 68 (6) ◽  
pp. 1611-1617 ◽  
Author(s):  
Hung-Chen Wang ◽  
Wei-Che Lin ◽  
Tzu-Ming Yang ◽  
Yu-Jun Lin ◽  
Nai-Wen Tsai ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Subarachnoid Hemorrhage ◽  
Magnetic Resonance ◽  
Cerebral Infarction ◽  
Adhesion Molecules ◽  
High Frequency ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Resonance Imaging ◽  
Circulating Markers

Abstract BACKGROUND: Serum concentrations of adhesion molecules may be connected to the pathogenesis of delayed cerebral infarction (DCI) after aneurysmal subarachnoid hemorrhage (SAH). OBJECTIVE: To test the hypothesis that levels of adhesion molecules are substantially increased after DCI and decreased thereafter and that these levels can predict treatment outcomes. METHODS: Serial circulating markers of adhesion molecules were examined in 21 consecutive SAH patients and 2 risk control subjects. All underwent cerebral angiography and magnetic resonance imaging to confirm the DCI. The timing of magnetic resonance imaging was fixed in the acute phase and before hospital discharge. RESULTS: Symptomatic DCI developed in 33% of the patients (7 of 21). Statistical analysis of levels of adhesion molecules between patients with and those without DCI revealed that soluble (s) L-selectin, sP-selectin, and sE-selectin concentrations significantly increased after symptomatic DCI (P = .003, .013, and .043, respectively). Only higher sL-selectin level on presentation (cutoff value > 636 ng/mL) was significantly associated with poor outcome after 6 months of follow-up. CONCLUSION: Increased sL-selectin, sP-selectin, and sE-selectin levels imply risks of symptomatic DCI after aneurysmal SAH. The high frequency of symptomatic DCI and higher sL-selectin level on presentation may be associated with worse outcomes.

Abstract W P171: Findings of Magnetic Resonance Imaging and Carotid Duplex as Predictors of Recurrent Brain Infarction -Bingo Cerebral Infarction Study 1-

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Kiyoshi Nakazaki ◽  
Shinichi Takeshima ◽  
Masaru Kuriyama
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cerebral Infarction ◽  
Artery Stenosis ◽  
Lacunar Infarction ◽  
Resonance Imaging ◽  
Ischemic Brain ◽  
Inversion Recovery Imaging ◽  
Carotid Duplex

Introduction: To retrospectively evaluate whether findings of magnetic resonance imaging (MRI) and carotid duplex are predictors of recurrent cerebral infarction. Methods: Between 2007 and 2010, 1324 patients underwent carotid duplex, magnetic resonance angiography, fluid-attenuated inversion recovery imaging, and T2*-weighted imaging during first admission for cerebral infarction and were discharged with a modified Rankin Scale (mRS) score of 0-3. Of the 1324 patients, 1138 (86.0%) were followed up (median age, 70 years; male:female ratio, 64%:36%). Atherothrombotic infarction, lacunar infarction, cardiogenic embolism, and other infarctions occurred in 435, 430, 246, and 27 patients, respectively. Results: The median follow-up duration was 44.5 months; 84.4% patients underwent follow-up MRI. New ischemic brain events occurred in 213 patients (18.7%). Transient ischemic attack occurred as the first new ischemic brain event in 44 patients. New asymptomatic cerebral infarction appeared in 100 patients before or without new ischemic brain events. Symptomatic cerebral infarction (SCI) recurred in 172 cases (15.1%), and the median duration between discharge and recurrence was 18.6 months (range, 0.2-69.5 months). Atherothrombotic infarction, lacunar infarction, and cardiogenic embolism recurred in 64, 64, and 42 patients, respectively. At the last follow-up, mRS score was 0-3 in 1029 patients and 27 patients died. Intracranial artery stenosis and micro-bleeding were significant predictors of SCI after lacunar infarction. Pre-admission asymptomatic old cerebral infarction was a significant predictor of SCI after 3 subtypes. Internal carotid artery stenosis >50% on carotid duplex was a significant predictor of SCI after atherothrombotic infarction. Conclusion: Findings of MRI and carotid duplex may be important predictors of recurrent cerebral infarction.

scholarly journals Magnetic Resonance Imaging and Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage

Stroke ◽  
2017 ◽  
Vol 48 (1) ◽  
pp. 239-245 ◽  
Author(s):  
Lisa A. van der Kleij ◽  
Jill B. De Vis ◽  
Jean-Marc Olivot ◽  
Lionel Calviere ◽  
Christophe Cognard ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Subarachnoid Hemorrhage ◽  
Cerebral Ischemia ◽  
Magnetic Resonance ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Resonance Imaging

scholarly journals Successful Serial Imaging of the Mouse Cerebral Arteries Using Conventional 3-T Magnetic Resonance Imaging

2015 ◽  
Vol 35 (9) ◽  
pp. 1523-1527 ◽  
Author(s):  
Hiroshi Makino ◽  
Kazuya Hokamura ◽  
Takahiro Natsume ◽  
Tetsuro Kimura ◽  
Yoshinobu Kamio ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Subarachnoid Hemorrhage ◽  
Magnetic Resonance ◽  
Mouse Model ◽  
Intracranial Aneurysm ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Cerebral Arteries ◽  
Resonance Imaging ◽  
Serial Imaging ◽  
Aneurysm Formation

Serial imaging studies can be useful in characterizing the pathologic and physiologic remodeling of cerebral arteries in various mouse models. We tested the feasibility of using a readily available, conventional 3-T magnetic resonance imaging (MRI) to serially image cerebrovascular remodeling in mice. We utilized a mouse model of intracranial aneurysm as a mouse model of the dynamic, pathologic remodeling of cerebral arteries. Aneurysms were induced by hypertension and a single elastase injection into the cerebrospinal fluid. For the mouse cerebrovascular imaging, we used a conventional 3-T MRI system and a 40-mm saddle coil. We used non-enhanced magnetic resonance angiography (MRA) to detect intracranial aneurysm formation and T2-weighted imaging to detect aneurysmal subarachnoid hemorrhage. A serial MRI was conducted every 2 to 3 days. MRI detection of aneurysm formation and subarachnoid hemorrhage was compared against the postmortem inspection of the brain that was perfused with dye. The imaging times for the MRA and T2-weighted imaging were 3.7 ± 0.5 minutes and 4.8 ± 0.0 minutes, respectively. All aneurysms and subarachnoid hemorrhages were correctly identified by two masked observers on MRI. This MRI-based serial imaging technique was useful in detecting intracranial aneurysm formation and subarachnoid hemorrhage in mice.

Intradural Spinal Cord Tumor Presenting as a Subarachnoid Hemorrhage: Magnetic Resonance Imaging Diagnosis

Neurosurgery ◽  
1990 ◽  
Vol 27 (4) ◽  
pp. 631-634 ◽  
Author(s):  
David J. Chalif ◽  
Karen Black ◽  
Dwight Rosenstein
Keyword(s):  
Magnetic Resonance Imaging ◽  
Spinal Cord ◽  
Subarachnoid Hemorrhage ◽  
Magnetic Resonance ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Spinal Cord Tumor ◽  
Signs And Symptoms ◽  
Resonance Imaging ◽  
Gadolinium Enhancement ◽  
Negative Findings

Abstract Negative findings on four-vessel angiography after a subarachnoid hemorrhage are seen in 5 to 30% of patients. A previously silent lesion in the spinal canal may be responsible for the ictus in a small percentage of this group. The etiological factors include tumors and arteriovenous malformations: however, investigations of such lesions have been limited to patients with signs and symptoms of spinal cord or nerve root pathological processes. This report describes the management of a 56-year-old woman with clinical findings typical of an aneurysmal subarachnoid hemorrhage and negative findings on cerebral angiography, in whom magnetic resonance imaging with gadolinium enhancement revealed an intradural extramedullary cervical schwannoma. For this reason, cervicothoracic magnetic resonance imaging with gadolinium enhancement should be considered as an adjunctive scanning examination in all patients with a subarachnoid hemorrhage and negative findings on angiography.

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