scholarly journals Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning

Development ◽  
2003 ◽  
Vol 130 (20) ◽  
pp. 4895-4906 ◽  
Author(s):  
J. G. Corbin
Keyword(s):  
Homeodomain Proteins ◽  
Combinatorial Function

scholarly journals Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors

FEBS Letters ◽  
2001 ◽  
Vol 499 (3) ◽  
pp. 274-278 ◽  
Author(s):  
Despina Stamataki ◽  
Maria-Christina Kastrinaki ◽  
Baljinder S. Mankoo ◽  
Vassilis Pachnis ◽  
Domna Karagogeos
Keyword(s):  
Transcription Factors ◽  
Homeodomain Proteins

scholarly journals Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development

2015 ◽  
Vol 29 (6) ◽  
pp. 842-855 ◽  
Author(s):  
Huimin Xie ◽  
Hanne M. Hoffmann ◽  
Jason D. Meadows ◽  
Susan L. Mayo ◽  
Crystal Trang ◽  
...  
Keyword(s):  
Homeodomain Proteins ◽  
Pituitary Development

scholarly journals DNA bending by the a1 and α2 homeodomain proteins from yeast

1995 ◽  
Vol 23 (7) ◽  
pp. 1239-1243 ◽  
Author(s):  
Dana L. Smith ◽  
Arshad B. Desai ◽  
Alexander D. Johnson
Keyword(s):  
Dna Bending ◽  
Homeodomain Proteins

scholarly journals Identification of Homeodomain Proteins, PBX1 and PREP1, Involved in the Transcription of Murine Leukemia Virus

2003 ◽  
Vol 23 (3) ◽  
pp. 831-841 ◽  
Author(s):  
Sheng-Hao Chao ◽  
John R. Walker ◽  
Sumit K. Chanda ◽  
Nathanael S. Gray ◽  
Jeremy S. Caldwell
Keyword(s):  
Murine Leukemia Virus ◽  
Kinase Inhibitors ◽  
Leukemia Virus ◽  
Moloney Murine Leukemia Virus ◽  
Viral Transcription ◽  
Long Terminal Repeats ◽  
Homeodomain Proteins ◽  
Cellular Genes ◽  
Simplex Virus ◽  
Murine Leukemia

ABSTRACT Cyclin-dependent kinase inhibitors (CDKIs) have been shown to block human immunodeficiency virus and herpes simplex virus. It is hypothesized that CDKIs block viral replication by inhibiting transcription of specific cellular genes. Here we find that three CDKIs, flavopiridol, purvalanol A, and methoxy-roscovitine, block Moloney murine leukemia virus (MLV) transcription events. Using gene expression microarray technology to examine the inhibitory effects of CDKIs, we observed a cellular gene, the pre-B-cell leukemia transcription factor 1 (Pbx1) gene, down-regulated by CDKI treatment. The PBX consensus element (PCE), TGATTGAC, is conserved in the long terminal repeats of several murine retroviruses, including Moloney MLV. Mutations in the PCE completely inhibited viral transcription whereas overexpression of PBX1 and a PBX1-associated protein, PREP1, enhanced viral transcription. The interaction between the PCE and PBX1-PREP1 proteins was confirmed by gel shift experiments. Blocking PBX1 protein synthesis resulted in a significant decrease in viral transcription. Collectively, our results represent the first work demonstrating that the homeodomain proteins PBX1 and PREP1 are cellular factors involved in Moloney MLV transcription regulation.

scholarly journals Structural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type Specification

2011 ◽  
Vol 286 (50) ◽  
pp. 42971-42980 ◽  
Author(s):  
Morgan S. Gadd ◽  
Mugdha Bhati ◽  
Cy M. Jeffries ◽  
David B. Langley ◽  
Jill Trewhella ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Neural Cell ◽  
Structural Basis ◽  
Cell Type ◽  
Homeodomain Proteins ◽  
Partial Redundancy ◽  
Type Specification ◽  
Lim Homeodomain

scholarly journals A Homeobox Gene Is Essential for Conidiogenesis of the Rice Blast Fungus Magnaporthe oryzae

2010 ◽  
Vol 23 (4) ◽  
pp. 366-375 ◽  
Author(s):  
Wende Liu ◽  
Shiyong Xie ◽  
Xinhua Zhao ◽  
Xin Chen ◽  
Wenhui Zheng ◽  
...  
Keyword(s):  
Magnaporthe Oryzae ◽  
Rice Blast ◽  
Homeobox Gene ◽  
Gene Replacement ◽  
Fungal Genome ◽  
Protein Signaling ◽  
Homeodomain Proteins ◽  
Conidial Production ◽  
Targeted Gene Replacement ◽  
Severity Of The Disease

Magnaporthe oryzae starts its infection by the attachment of pyriform conidia on rice tissues, and severity of the disease epidemic is proportional to the quantity of conidia produced in the rice blast lesions. However, the mechanism of conidial production is not well understood. Homeodomain proteins play critical roles in regulating various growth and developmental processes in fungi and other eukaryotes. Through targeted gene replacement, we find that deletion of HTF1, one of seven homeobox genes in the fungal genome, does not affect mycelial growth but causes total defect of conidial production. Further observation revealed that the Δhtf1 mutant produces significantly more conidiophores, which curve slightly near the tip but could not develop sterigmata-like structures. Although the Δhtf1 mutant fails to form conidia, it could still develop melanized appressoria from hyphal tips and infect plants. The expression level of HTF1 is significantly reduced in the Δmgb1 G-β and ΔcpkA deletion mutant, and the ACR1 but not CON7 gene that encodes transcription factor required for normal conidiogenesis is significantly downregulated in the Δhtf1 mutant. These data suggest that the HTF1 gene is essential for conidiogenesis, and may be functionally related to the trimeric G-protein signaling and other transcriptional regulators that are known to be important for conidiation in M. oryzae.

Homeodomain Proteins in Pancreas Development

2001 ◽  
pp. 197-212 ◽  
Author(s):  
Ulf Ahlgren ◽  
Helena Edlund
Keyword(s):  
Pancreas Development ◽  
Homeodomain Proteins
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