scholarly journals Midline crossing by gustatory receptor neuron axons is regulated byfruitless, doublesexand the Roundabout receptors

Development ◽  
2009 ◽  
Vol 137 (2) ◽  
pp. 323-332 ◽  
Author(s):  
David J. Mellert ◽  
Jon-Michael Knapp ◽  
Devanand S. Manoli ◽  
Geoffrey W. Meissner ◽  
Bruce S. Baker
Keyword(s):  
Receptor Neuron ◽  
Gustatory Receptor ◽  
Midline Crossing ◽  
Roundabout Receptors

Gustatory receptor neuron responds to DEET and other insect repellents in the yellow-fever mosquito, Aedes aegypti

2013 ◽  
Vol 100 (3) ◽  
pp. 269-273 ◽  
Author(s):  
Jillian L. Sanford ◽  
Vonnie D. C. Shields ◽  
Joseph C. Dickens
Keyword(s):  
Aedes Aegypti ◽  
Yellow Fever ◽  
Receptor Neuron ◽  
Gustatory Receptor ◽  
Yellow Fever Mosquito ◽  
Insect Repellents

scholarly journals Involvement of a Gr2a-Expressing Drosophila Pharyngeal Gustatory Receptor Neuron in Regulation of Aversion to High-Salt Foods

2017 ◽  
Vol 40 (5) ◽  
pp. 331-338 ◽  
Author(s):  
Haein Kim ◽  
Yong Taek Jeong ◽  
Min Sung Choi ◽  
Jaekyun Choi ◽  
Seok Jun Moon ◽  
...  
Keyword(s):  
High Salt ◽  
Receptor Neuron ◽  
Gustatory Receptor

scholarly journals Salty surfaces deter feeding in a blood-sucking disease vector

2021 ◽  
Author(s):  
G Pontes ◽  
JM Latorre-Estivalis ◽  
ML Gutiérrez ◽  
A Cano ◽  
M Berón de Astrada ◽  
...  
Keyword(s):  
Sensory Modality ◽  
Blood Feeding ◽  
Rhodnius Prolixus ◽  
High Salt ◽  
Receptor Neuron ◽  
Gustatory Receptor ◽  
Physiological Basis ◽  
Disease Vector ◽  
Blood Sucking ◽  
The Central Nervous System

AbstractSalts are essential nutrients required for many physiological processes, and deficient or excessive salt results in adverse health problems. Taste is the ultimate sensory modality involved in resource quality assessment, resulting in acceptance or rejection. Here, we show that detection of high-salt substrates by a salt-sensitive antennal gustatory receptor neuron, S1-GRN, results in feeding avoidance in the hematophagous bug Rhodnius prolixus. Knock-down of two antennal-expressed amiloride-sensitive pickpocket channel receptors (PPKs; RproPPK014276 and RproPPK28) using RNA interference, prevents avoidance of bugs to high-salt substrates. Tracing antennal GRNs to the central nervous system reveals the antennal lobes as a gustatory processing center. The identification of the gustatory basis of high-salt detection in a blood feeder provides novel targets to prevent biting and feeding, as well as to promote substrate avoidance in a relevant disease vector.Significance StatementDetection of aversive gustatory stimuli induces avoidance responses in animals. Avoidance acquires particular interest if it reduces the biting rates of blood-feeding insects of medical relevance. Here we describe the molecular and physiological basis of high-salt detection in the blood-sucking disease vector Rhodnius prolixus. We show that detection of high-salt substrates through two PPK receptors expressed in an antennal gustatory receptor neuron produces feeding avoidance. Understanding these gustatory-driven aversive responses allows the hitherto overlooked use of gustatory molecules as a complement to known olfactory repellents.

Roundabout receptors: new actors in bone metastatic niche formation

2016 ◽  
Author(s):  
Lise Clement-Demange ◽  
Pape Francois Le ◽  
Benedicte Eckel ◽  
Sandra Geraci ◽  
Chantal Diaz-Latoud ◽  
...  
Keyword(s):  
Metastatic Niche ◽  
Niche Formation ◽  
Roundabout Receptors
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