Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells

Development ◽  
2013 ◽  
Vol 140 (7) ◽  
pp. 1397-1401 ◽  
Author(s):  
H. J. Lee ◽  
D. Gallego-Ortega ◽  
A. Ledger ◽  
D. Schramek ◽  
P. Joshi ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Luminal Progenitor ◽  
Luminal Progenitor Cells ◽  
Secretory Differentiation

scholarly journals A requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 mice

Oncogene ◽  
2013 ◽  
Vol 33 (4) ◽  
pp. 411-420 ◽  
Author(s):  
J L Little ◽  
V Serzhanova ◽  
E Izumchenko ◽  
B L Egleston ◽  
E Parise ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Mammary Tumorigenesis ◽  
Luminal Progenitor ◽  
Luminal Progenitor Cells

scholarly journals Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A

2009 ◽  
Vol 23 (20) ◽  
pp. 2382-2387 ◽  
Author(s):  
D. Yamaji ◽  
R. Na ◽  
Y. Feuermann ◽  
S. Pechhold ◽  
W. Chen ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Progenitor Cells ◽  
Luminal Progenitor ◽  
Luminal Progenitor Cells

scholarly journals Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors

Cell Reports ◽  
2015 ◽  
Vol 13 (10) ◽  
pp. 2147-2158 ◽  
Author(s):  
Supreet Agarwal ◽  
Paul G. Hynes ◽  
Heather S. Tillman ◽  
Ross Lake ◽  
Wassim G. Abou-Kheir ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Luminal Progenitor ◽  
Prostate Tumors ◽  
Luminal Progenitor Cells

scholarly journals Inference of tissue relative proportions of the breast epithelial cell types luminal progenitor, basal, and luminal mature

2021 ◽  
Author(s):  
Thomas E Bartlett ◽  
Swati Chandna ◽  
Sandipan Roy
Keyword(s):  
Progenitor Cells ◽  
Hormone Receptor ◽  
Breast Tissue ◽  
Breast Tumour ◽  
Breast Epithelial Cell ◽  
Fanconi Anaemia ◽  
Breast Cancers ◽  
Luminal Progenitor ◽  
Tissue Samples ◽  
Luminal Progenitor Cells

Hormone receptor negative breast cancers are highly aggressive, and are thought to originate from a subtype of epithelial cells called the luminal progenitor. In this paper, we show how to quantify the number of luminal progenitor cells as well as other epithelial subtypes in breast tissue samples using DNA and RNA based measurements. We find elevated levels of these hormone receptor negative luminal progenitor cells in breast tumour biopsies of hormone receptor negative cancers, as well as in healthy breast tissue samples from BRCA1 (FANCS) mutation carriers. We also find that breast tumours from carriers of heterozygous mutations in non-BRCA Fanconi Anaemia pathway genes are much more likely to be hormone receptor negative.

Abstract 2223: Rapamycin suppresses ErbB2-overexpressing mammary tumors through selective inhibition of luminal progenitor cells and tumor-initiating cells

2017 ◽  
Author(s):  
Qingxia Zhao ◽  
Amanda B. Parris ◽  
Erin W. Howard ◽  
Ming Zhao ◽  
Zhiying Guo ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Mammary Tumors ◽  
Selective Inhibition ◽  
Luminal Progenitor ◽  
Tumor Initiating Cells ◽  
Luminal Progenitor Cells

scholarly journals Spatially correlated phenotyping reveals K5-positive luminal progenitor cells and p63-K5/14-positive stem cell-like cells in human breast epithelium

2018 ◽  
Vol 98 (8) ◽  
pp. 1065-1075 ◽  
Author(s):  
Werner Boecker ◽  
Laura van Horn ◽  
Göran Stenman ◽  
Christine Stürken ◽  
Udo Schumacher ◽  
...  
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Luminal Progenitor ◽  
Human Breast ◽  
Breast Epithelium ◽  
Spatially Correlated ◽  
Luminal Progenitor Cells

scholarly journals Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14

2011 ◽  
Vol 31 (22) ◽  
pp. 4609-4622 ◽  
Author(s):  
M.-L. Asselin-Labat ◽  
K. D. Sutherland ◽  
F. Vaillant ◽  
D. E. Gyorki ◽  
D. Wu ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Progenitor Cells ◽  
Luminal Progenitor ◽  
Putative Tumor Suppressor ◽  
Luminal Progenitor Cells

scholarly journals 22 Luminal progenitor cells as a new target in castration-resistant prostate cancer (CRPC)

2018 ◽  
Author(s):  
V Goffin ◽  
F Boutillon ◽  
A Quesnel ◽  
M Leprévost ◽  
L Sackmann Sala ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Progenitor Cells ◽  
Luminal Progenitor ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Luminal Progenitor Cells

scholarly journals Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Young A. Yoo ◽  
Meejeon Roh ◽  
Anum F. Naseem ◽  
Barbara Lysy ◽  
Mohamed M. Desouki ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Luminal Progenitor ◽  
Castration Resistant ◽  
Luminal Progenitor Cells ◽  
Tumour Initiation
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