scholarly journals Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst

Development ◽  
2014 ◽  
Vol 141 (5) ◽  
pp. 1001-1010 ◽  
Author(s):  
G. C. Le Bin ◽  
S. Munoz-Descalzo ◽  
A. Kurowski ◽  
H. Leitch ◽  
X. Lou ◽  
...  
Keyword(s):  
Inner Cell Mass ◽  
Cell Mass ◽  
Mouse Blastocyst ◽  
Lineage Priming

When and how does cell division order influence cell allocation to the inner cell mass of the mouse blastocyst?

Development ◽  
1987 ◽  
Vol 100 (2) ◽  
pp. 325-332
Author(s):  
C.L. Garbutt ◽  
M.H. Johnson ◽  
M.A. George
Keyword(s):  
Cell Division ◽  
Cell Population ◽  
Inner Cell Mass ◽  
Cell Mass ◽  
Cell Lineage ◽  
The Other ◽  
Mouse Blastocyst ◽  
Short Term ◽  
Cell Stage ◽  
Cell Embryo

Aggregate 8-cell embryos were constructed from four 2/8 pairs of blastomeres, one of which was marked with a short-term cell lineage marker and was also either 4 h older (derived from an early-dividing 4-cell) or 4 h younger (derived from a late-dividing 4-cell) than the other three pairs. The aggregate embryos were cultured to the 16-cell stage, at which time a second marker was used to label the outside cell population. The embryos were then disaggregated and each cell was examined to determine its labelling pattern. From this analysis, we calculated the relative contributions to the inside cell population of the 16-cell embryo of older and younger cells. Older cells were found to contribute preferentially. However, if the construction of the aggregate 8-cell embryo was delayed until each of the contributing 2/8 cell pairs had undergone intercellular flattening and then had been exposed to medium low in calcium to reverse this flattening immediately prior to aggregation, the advantage possessed by the older cells was lost. These results support the suggestion that older cells derived from early-dividing 4-cell blastomeres contribute preferentially to the inner cell mass as a result of being early-flattening cells.

scholarly journals Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2

2017 ◽  
Vol 41 (5) ◽  
pp. 496-510.e5 ◽  
Author(s):  
Minjung Kang ◽  
Vidur Garg ◽  
Anna-Katerina Hadjantonakis
Keyword(s):  
Inner Cell Mass ◽  
Cell Mass ◽  
Mouse Blastocyst

An investigation of inner cell mass and trophoblast tissues following their isolation from the mouse blastocyst

Development ◽  
1972 ◽  
Vol 28 (2) ◽  
pp. 279-312
Author(s):  
R. L. Gardner ◽  
M. H. Johnson
Keyword(s):  
Inner Cell Mass ◽  
Cell Mass ◽  
Mouse Blastocyst ◽  
Or Groups ◽  
Ectoplacental Cone

1. Inner cell mass (ICM) and trophoblast were isolated from 3½-day post-coitum mouse blastocysts by microsurgery. 2. Trophoblastic fragments formed vesicles in culture but did not aggregate with other such fragments. They proved as effective as intact blastocysts in inducing decidua in recipient uteri, but thereafter failed to proliferate. 3. Isolated ICMs remained as solid balls of cells that readily aggregated in pairs or groups in culture but failed to induce implantation changes in receptive uteri. 4. Possible explanations for the failure of isolated trophoblast to proliferate after implantation are discussed. It is argued that presence of ICM tissue is necessary for trophoblast proliferation, and suggested that the ICM exerts its effect by controlling development of the ectoplacental cone.

scholarly journals PDGF signaling is required for primitive endoderm cell survival in the inner cell mass of the mouse blastocyst

Stem Cells ◽  
2013 ◽  
Vol 31 (9) ◽  
pp. 1932-1941 ◽  
Author(s):  
Jérôme Artus ◽  
Minjung Kang ◽  
Michel Cohen-Tannoudji ◽  
Anna-Katerina Hadjantonakis
Keyword(s):  
Cell Survival ◽  
Inner Cell Mass ◽  
Cell Mass ◽  
Primitive Endoderm ◽  
Mouse Blastocyst ◽  
Endoderm Cell ◽  
Pdgf Signaling

Energy metabolism of the trophectoderm and inner cell mass of the mouse blastocyst

1993 ◽  
Vol 267 (3) ◽  
pp. 337-343 ◽  
Author(s):  
Laura C. Hewitson ◽  
Henry J. Leese
Keyword(s):  
Energy Metabolism ◽  
Inner Cell Mass ◽  
Cell Mass ◽  
Mouse Blastocyst

scholarly journals Betaine Homocysteine Methyltransferase Is Active in the Mouse Blastocyst and Promotes Inner Cell Mass Development

2012 ◽  
Vol 287 (39) ◽  
pp. 33094-33103 ◽  
Author(s):  
Martin B. Lee ◽  
Megan Kooistra ◽  
Baohua Zhang ◽  
Sandy Slow ◽  
Amanda L. Fortier ◽  
...  
Keyword(s):  
Inner Cell Mass ◽  
Cell Mass ◽  
Mouse Blastocyst ◽  
Mass Development ◽  
Betaine Homocysteine Methyltransferase ◽  
Homocysteine Methyltransferase

In vitro development of core cells of the inner cell mass of the mouse blastocyst: Effects of conditioned medium

1979 ◽  
Vol 208 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Sui Bi Atienza-Samols ◽  
Michael I. Sherman
Keyword(s):  
Conditioned Medium ◽  
Inner Cell Mass ◽  
Cell Mass ◽  
Mouse Blastocyst ◽  
In Vitro Development ◽  
Vitro Development

scholarly journals Dynamic erasure of X chromosome upregulation during iPSC reprogramming and in the inner cell mass

2020 ◽  
Author(s):  
D Chandel ◽  
C H Naik ◽  
S Gayen
Keyword(s):  
X Chromosome ◽  
Inner Cell Mass ◽  
Cell Mass ◽  
Substantial Evidence ◽  
Mouse Blastocyst ◽  
Kinetics Of

SummaryRecent studies have provided substantial evidence supporting Ohno’s hypothesis that upregulation of active X chromosome genes balances the dosage relative to autosomal genes. Here, we found the evidence for erasure of active X-chromosome upregulation upon reactivation of inactive X in female cells during iPSC reprogramming and in the inner cell mass of mouse blastocyst. Moreover, our analysis revealed that the kinetics of erasure of X upregulation is tightly linked with the dynamics of X reactivation.Abstract Figure

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