scholarly journals Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling

Development ◽  
2018 ◽  
Vol 145 (4) ◽  
pp. dev155317 ◽  
Author(s):  
Joshua V. Troll ◽  
M. Kristina Hamilton ◽  
Melissa L. Abel ◽  
Julia Ganz ◽  
Jennifer M. Bates ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Intestinal Epithelium ◽  
Secretory Cell ◽  
Cell Determination

scholarly journals Notch signaling controls the balance of ciliated and secretory cell fates in developing airways

Development ◽  
2009 ◽  
Vol 136 (13) ◽  
pp. 2297-2307 ◽  
Author(s):  
P.-N. Tsao ◽  
M. Vasconcelos ◽  
K. I. Izvolsky ◽  
J. Qian ◽  
J. Lu ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Secretory Cell ◽  
Cell Fates

192 Notch Signaling Regulates Expression of the KrüPpel-Like Factor 4 Gene in the Intestinal Epithelium

2008 ◽  
Vol 134 (4) ◽  
pp. A-33
Author(s):  
Amr Ghaleb ◽  
Gaurav Aggarwal ◽  
Agnieszka Bialkowska ◽  
Mandayam O. Nandan ◽  
Vincent W. Yang
Keyword(s):  
Notch Signaling ◽  
Intestinal Epithelium

scholarly journals NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer

2010 ◽  
Vol 70 (4) ◽  
pp. 1469-1478 ◽  
Author(s):  
S. S. Sikandar ◽  
K. T. Pate ◽  
S. Anderson ◽  
D. Dizon ◽  
R. A. Edwards ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Differentiation ◽  
Notch Signaling ◽  
Secretory Cell ◽  
Tumor Initiating Cells ◽  
Self Renewal

Morphological study of the gut in Sagitta setosa, S. serratodentata and S. pacifica (Chaetognatha). Functional implications in digestive processes

1999 ◽  
Vol 79 (6) ◽  
pp. 1097-1109 ◽  
Author(s):  
Y. Perez ◽  
J. Arnaud ◽  
M. Brunet ◽  
J.-P. Casanova ◽  
J. Mazza
Keyword(s):  
Intestinal Epithelium ◽  
Morphological Study ◽  
Secretory Cell ◽  
Secretory Granules ◽  
Ciliated Cell ◽  
Posterior Part ◽  
Cell Types ◽  
Cell Type ◽  
Distinct Cell ◽  
Functional Implications

The study of the digestive epithelium in Sagitta setosa, S. serratodentata, and S. pacifica revealed only a few morphological and cytological differences among the three species. The gut was divided in two main regions. The first is the cephalic region where the epithelium is composed of three distinct cell types (S1, S2, and S3), the ultrastructure of which is probably specialized either for the synthesis of mucosubstances (S1), or enzymes (S3), or both (S2). The second region of the gut extends to the trunk and is mainly composed of the intestine and a short vertical rectum. No intestinal diverticula were observed. The intestinal epithelium displayed two ciliated cell types, anteriorly, a secretory cell type (S4) containing large mucus-like granules, and a second cell type (A) predominated in the posterior part of the intestine. A-cells appear to have two main functions. Although they exhibit secretory granules, they also display typical endocytotic features in their upper half, i.e. coated vesicles, a well-developed tubulo–vesicular network and two distinct types of digestive vacuoles corresponding to an endosome–lysosome-like system. From the distribution and presumed function of the cells, the gut may be divided in two main functional units, i.e. the cephalic and trunk units.

scholarly journals Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility

2013 ◽  
Vol 376 (2) ◽  
pp. 171-186 ◽  
Author(s):  
Gillian Roach ◽  
Rachel Heath Wallace ◽  
Amy Cameron ◽  
Rifat Emrah Ozel ◽  
Cintia F. Hongay ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Intestinal Epithelium ◽  
Intestinal Motility ◽  
Secretory Cell

scholarly journals Notch signaling drives development of Barrett’s metaplasia from Dclk1-positive epithelial tuft cells in the murine gastric mucosa

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Bettina Kunze ◽  
Moritz Middelhoff ◽  
H. Carlo Maurer ◽  
Tatiana Agibalova ◽  
Akanksha Anand ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Secretory Cell ◽  
Notch Receptor ◽  
Neoplastic Progression ◽  
Epithelial Tumor ◽  
Genetic Ablation ◽  
Stem Cell Maintenance ◽  
Cellular Origin ◽  
Tuft Cells ◽  
Notch Activation

AbstractBarrett’s esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC), but its cellular origin and mechanism of neoplastic progression remain unresolved. Notch signaling, which plays a key role in regulating intestinal stem cell maintenance, has been implicated in a number of cancers. The kinase Dclk1 labels epithelial post-mitotic tuft cells at the squamo-columnar junction (SCJ), and has also been proposed to contribute to epithelial tumor growth. Here, we find that genetic activation of intracellular Notch signaling in epithelial Dclk1-positive tuft cells resulted in the accelerated development of metaplasia and dysplasia in a mouse model of BE (pL2.Dclk1.N2IC mice). In contrast, genetic ablation of Notch receptor 2 in Dclk1-positive cells delayed BE progression (pL2.Dclk1.N2fl mice), and led to increased secretory cell differentiation. The accelerated BE progression in pL2.Dclk1.N2IC mice correlated with changes to the transcriptomic landscape, most notably for the activation of oncogenic, proliferative pathways in BE tissues, in contrast to upregulated Wnt signalling in pL2.Dclk1.N2fl mice. Collectively, our data show that Notch activation in Dclk1-positive tuft cells in the gastric cardia can contribute to BE development.

422 – Epithelial Ido1 Modulates Ahr and Notch Signaling to Enhance Secretory Cell Differentiation, Augment Mucus Barrier, and Alter Microbiota

2019 ◽  
Vol 156 (6) ◽  
pp. S-82
Author(s):  
David M. Alvarado ◽  
Baosheng Chen ◽  
Micah Iticovici ◽  
Kelli L. VanDussen ◽  
Nurmohammad Shaikh ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Notch Signaling ◽  
Secretory Cell ◽  
Mucus Barrier

303 ORAL Intestinal inactivation of canonical Notch signaling by removal of protein O-fucosyltransferase 1 triggers secretory cell fate differentiation

2007 ◽  
Vol 5 (4) ◽  
pp. 57-58
Author(s):  
S. Guilmeau ◽  
M. Flandez ◽  
L. Bancroft ◽  
P. Stanley ◽  
L.H. Augenlicht
Keyword(s):  
Notch Signaling ◽  
Cell Fate ◽  
Secretory Cell

scholarly journals JAG1-Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway Epithelium

2016 ◽  
Vol 12 (4) ◽  
pp. 454-463 ◽  
Author(s):  
Kazunori Gomi ◽  
Michelle R. Staudt ◽  
Jacqueline Salit ◽  
Robert J. Kaner ◽  
Jonna Heldrich ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Notch Signaling ◽  
Airway Epithelium ◽  
Secretory Cell ◽  
Human Airway ◽  
Human Airway Epithelium

11 EPITHELIAL IDO1 MODULATES AHR AND NOTCH SIGNALING TO ENHANCE SECRETORY CELL DIFFERENTIATION AND ALTERS MUCUS-ASSOCIATED MICROBIOTA

2019 ◽  
Vol 156 (3) ◽  
pp. S84
Author(s):  
David M. Alvarado ◽  
Srikanth Santhanam ◽  
Micah Iticovici ◽  
Kelli VanDussen ◽  
Nurmohammad Shaikh ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Notch Signaling ◽  
Secretory Cell
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