scholarly journals Role of a G i2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool

2007 ◽  
Vol 120 (13) ◽  
pp. 2171-2178 ◽  
Author(s):  
M. F. Lopez-Aranda ◽  
M. J. Acevedo ◽  
A. Gutierrez ◽  
P. Koulen ◽  
Z. U. Khan
Keyword(s):  
Splice Variant ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Protein Splice ◽  
Receptor Pool

Role of dopamine D2 receptor in hypothalamic regulation of energy homeostasis

2006 ◽  
Vol 27 (1) ◽  
pp. 88
Author(s):  
Sa Yong Kim ◽  
Kyu seok Kim ◽  
Seung Woo Shin ◽  
Min Sun Kim ◽  
Ja Hyun Baik
Keyword(s):  
Energy Homeostasis ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Hypothalamic Regulation

scholarly journals Publisher Correction: Role of Dopamine D2 Receptor in Stress-Induced Myelin Loss

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Mi-Hyun Choi ◽  
Ji Eun Na ◽  
Ye Ran Yoon ◽  
Hyo Jin Lee ◽  
Sehyoun Yoon ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2

scholarly journals Essential Role of Dopamine D2 Receptor in the Maintenance of Wakefulness, But Not in Homeostatic Regulation of Sleep, in Mice

2010 ◽  
Vol 30 (12) ◽  
pp. 4382-4389 ◽  
Author(s):  
W.-M. Qu ◽  
X.-H. Xu ◽  
M.-M. Yan ◽  
Y.-Q. Wang ◽  
Y. Urade ◽  
...  
Keyword(s):  
Essential Role ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Homeostatic Regulation ◽  
Dopamine D2

A positron emission tomography (PET) investigation of the role of striatal dopamine (D2) receptor availability in spatial cognition

NeuroImage ◽  
2005 ◽  
Vol 28 (1) ◽  
pp. 216-226 ◽  
Author(s):  
Suzanne J. Reeves ◽  
Paul M. Grasby ◽  
Robert J. Howard ◽  
R. Alexander Bantick ◽  
Marie-Claude Asselin ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Spatial Cognition ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Striatal Dopamine ◽  
Emission Tomography ◽  
Dopamine D2 ◽  
Positron Emission

scholarly journals Potential Role of Proton Pump Inhibitors Against Human DRD2 Receptor in Drug Induced Hyperprolactinemia

2020 ◽  
Vol 71 (10) ◽  
pp. 182-192
Author(s):  
Muhammad Ashfaq ◽  
S. Mobasher Ali Abid ◽  
Khalid Rauf ◽  
Yasser Msa Alkahraman ◽  
Muhammad Zeeshan Haroon ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Dopamine Receptors ◽  
Proton Pump ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Md Simulations ◽  
Serum Prolactin ◽  
Drug Induced ◽  
Dopamine D2

Dopamine is a catecholamine neurotransmitter that control several important functions via different dopamine receptors(D1-D5). The Dopamine (DRD2) receptor and other D2 family receptors (D3 and D4) are predominantly involved in the inhibitory activities. One vital role of dopamine receptors is its involvement in the endocrine regulations including the hormone synthesis and their secretion. The regulation of prolactin hormone is mainly controlled through DRD2 receptors. Blocking the delivery of dopamine at these DRD2 receptors will cause an increase in serum prolactin levels. PPI�s are among the widely prescribed medications used for multiple gastric hypersecretory disorders and are shown to cause increase in serum prolactin level. This study focuses on computational methods to test PPIs interaction with dopamine D2 receptor through molecular docking & dynamics studies. The 3D structure of protein and the drugs were downloaded from PDB and PubChem databases. Protein and ligands were prepared followed by molecular docking. Complexes with best docking poses were then proceeded towards MD simulations of 60 ns. Results were then analyzed. This study confirmed that there is prospective affinity between proton pump inhibitors and dopamine D2 receptor, and dynamically stable complexes are formed after drug-receptor binding. MD simulations results confirmed the binding affinity between PPIs and Dopamine D2 receptor, concluding that the use of PPIs may be involved in drug induced hyperprolactinemia and other related effects.

scholarly journals Role of Dopamine D2 Receptor in Stress-Induced Myelin Loss

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Mi-Hyun Choi ◽  
Ji Eun Na ◽  
Ye Ran Yoon ◽  
Hyo Jin Lee ◽  
Sehyoun Yoon ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2
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