scholarly journals The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration

2007 ◽  
Vol 120 (11) ◽  
pp. 1927-1934 ◽  
Author(s):  
Y.-y. Chuang ◽  
A. Valster ◽  
S. J. Coniglio ◽  
J. M. Backer ◽  
M. Symons
Keyword(s):  
Cell Migration ◽  
Focal Adhesion ◽  
Adhesion Formation ◽  
Focal Adhesion Formation ◽  
Rho Family

scholarly journals Acacetin and Pinostrobin Inhibit Malignant Breast Epithelial Cell Adhesion and Focal Adhesion Formation to Attenuate Cell Migration

2020 ◽  
Vol 19 ◽  
pp. 153473542091894 ◽  
Author(s):  
Aaron A. Jones ◽  
Scott Gehler
Keyword(s):  
Cell Migration ◽  
Cell Adhesion ◽  
Focal Adhesion ◽  
Adhesion Formation ◽  
Breast Epithelial Cell ◽  
Breast Epithelial Cells ◽  
Focal Adhesion Formation ◽  
Malignant Breast ◽  
Breast Epithelial ◽  
Mcf10a Cells

Naturally occurring flavonoids, such as acacetin and pinostrobin, disrupt a wide range of processes during tumor progression, such as cell proliferation, apoptosis, and angiogenesis. Although the antiproliferative and antiapoptotic effects of acacetin and pinostrobin have been studied using various cell lines, relatively little is known about the effects of acacetin and pinostrobin on cancer cell migration and metastasis. For instance, it is unclear whether acacetin or pinostrobin have any effect on breast cancer cell migration or adhesion. In this study, we assessed the effects of acacetin and pinostrobin on malignant MDA-MB-231 and T47D breast epithelial cells and non-tumorigenic MCF10A breast epithelial cells. Our results demonstrate that both acacetin and pinostrobin selectively inhibit the migration of both MDA-MB-231 and T47D cells in a dose-dependent manner while exhibiting blunted effects on MCF10A cells. Interestingly, neither compound had an effect on cell proliferation in any of the 3 cell lines. Furthermore, both acacetin and pinostrobin inhibit MDA-MB-231 and T47D cell adhesion, cell spreading, and focal adhesion formation, but have no significant effect on MCF10A cells. Collectively, these results suggest that both acacetin and pinostrobin selectively inhibit malignant breast epithelial cell migration through attenuation of cell adhesion and focal adhesion formation. These findings indicate that both acacetin and pinostrobin may serve as potential therapeutic options to target breast tumor cell migration during late-stage tumor progression.

scholarly journals Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation

2009 ◽  
Vol 315 (5) ◽  
pp. 863-876 ◽  
Author(s):  
Mitsuhiro Tachibana ◽  
Etsuko Kiyokawa ◽  
Shigeo Hara ◽  
Shun-ichiro Iemura ◽  
Tohru Natsume ◽  
...  
Keyword(s):  
Cell Migration ◽  
Focal Adhesion ◽  
Adhesion Formation ◽  
Ankyrin Repeat ◽  
Binding Partner ◽  
Focal Adhesion Formation ◽  
Repeat Domain ◽  
Ankyrin Repeat Domain

scholarly journals Loss of ADAM9 expression impairs β1 integrin endocytosis, focal adhesion formation and cancer cell migration

2017 ◽  
Vol 131 (1) ◽  
pp. jcs205393 ◽  
Author(s):  
Kasper J. Mygind ◽  
Jeanette Schwarz ◽  
Pranshu Sahgal ◽  
Johanna Ivaska ◽  
Marie Kveiborg
Keyword(s):  
Cell Migration ◽  
Cancer Cell ◽  
Focal Adhesion ◽  
Adhesion Formation ◽  
Β1 Integrin ◽  
Cancer Cell Migration ◽  
Focal Adhesion Formation

scholarly journals Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation

2013 ◽  
Vol 126 (20) ◽  
pp. 4572-4588 ◽  
Author(s):  
A. Steffen ◽  
M. Ladwein ◽  
G. A. Dimchev ◽  
A. Hein ◽  
L. Schwenkmezger ◽  
...  
Keyword(s):  
Cell Migration ◽  
Focal Adhesion ◽  
Adhesion Formation ◽  
Focal Adhesion Formation

scholarly journals The Ric-8A/Gα13/FAK signalling cascade controls focal adhesion formation during neural crest cell migration in Xenopus

Development ◽  
2018 ◽  
Vol 145 (22) ◽  
pp. dev164269 ◽  
Author(s):  
Gabriela Toro-Tapia ◽  
Soraya Villaseca ◽  
Andrea Beyer ◽  
Alice Roycroft ◽  
Sylvain Marcellini ◽  
...  
Keyword(s):  
Cell Migration ◽  
Neural Crest ◽  
Focal Adhesion ◽  
Adhesion Formation ◽  
Neural Crest Cell ◽  
Focal Adhesion Formation ◽  
Neural Crest Cell Migration ◽  
Crest Cell ◽  
Signalling Cascade
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