Distribution of guanylate cyclase within photoreceptor outer segments
Keyword(s):
Guanylate cyclases play an essential role in the recovery of vertebrate photoreceptor cells after light activation. Here, we have investigated how one such guanylate cyclase, RetGC-1, is distributed within light- and dark-adapted rod photoreceptor cells. Guanylate cyclase activity partitioned with the photoreceptor outer segment (OS) cytoskeleton in a light-sensitive manner. RetGC-1 was found to bind actin filaments in actin blot overlays, suggesting a mechanism for its association with the OS cytoskeleton. In retinal sections, this enzyme was immunodetected only in the OSs, where it appeared to be distributed throughout the disk membranes.
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1984 ◽
Vol 32
(8)
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pp. 834-838
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1984 ◽
Vol 98
(5)
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pp. 1788-1795
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1973 ◽
Vol 58
(3)
◽
pp. 650-661
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Keyword(s):
2010 ◽
Vol 21
(23)
◽
pp. 4076-4088
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Keyword(s):
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